PDLIM4

PDZ and LIM domain 4
Rendering based on PDB 2EEG.
Available structures PDB 2EEG, 2V1W
Identifiers
Symbols	PDLIM4; RIL
External IDs	OMIM: 603422 MGI: 1353470 HomoloGene: 2735 GeneCards: PDLIM4 Gene
Gene Ontology Molecular function • protein binding • zinc ion binding • metal ion binding Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8572	30794
Ensembl	ENSG00000131435	ENSMUSG00000020388
UniProt	P50479	Q5SWV2
RefSeq (mRNA)	NM_001131027.1	NM_019417.3
RefSeq (protein)	NP_001124499.1	NP_062290.2
Location (UCSC)	Chr 5: 131.59 – 131.61 Mb	Chr 11: 53.87 – 53.88 Mb
PubMed search	[1]	[2]

PDZ and LIM domain protein 4 is a protein that in humans is encoded by the PDLIM4 gene.^[1][2]

References

1. ^ Bashirova AA, Markelov ML, Shlykova TV, Levshenkova EV, Alibaeva RA, Frolova EI (Jun 1998). "The human RIL gene: mapping to human chromosome 5q31.1, genomic organization and alternative transcripts". Gene 210 (2): 239–45. doi:10.1016/S0378-1119(98)00080-8. PMID 9573374. 
2. ^ "Entrez Gene: PDLIM4 PDZ and LIM domain 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8572. 

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Cuppen E, van Ham M, Wansink DG, et al. (2000). "The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL". Eur. J. Cell Biol. 79 (4): 283–93. doi:10.1078/S0171-9335(04)70031-X. PMID 10826496. 
• Walma T, Spronk CA, Tessari M, et al. (2002). "Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL". J. Mol. Biol. 316 (5): 1101–10. doi:10.1006/jmbi.2002.5402. PMID 11884147. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Omasu F, Ezura Y, Kajita M, et al. (2003). "Association of genetic variation of the RIL gene, encoding a PDZ-LIM domain protein and localized in 5q31.1, with low bone mineral density in adult Japanese women". J. Hum. Genet. 48 (7): 342–5. doi:10.1007/s10038-003-0035-1. PMID 12908099. 
• Vallenius T, Scharm B, Vesikansa A, et al. (2004). "The PDZ-LIM protein RIL modulates actin stress fiber turnover and enhances the association of alpha-actinin with F-actin". Exp. Cell Res. 293 (1): 117–28. doi:10.1016/j.yexcr.2003.09.004. PMID 14729062. 
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442147. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• van den Berk LC, van Ham MA, te Lindert MM, et al. (2005). "The interaction of PTP-BL PDZ domains with RIL: an enigmatic role for the RIL LIM domain". Mol. Biol. Rep. 31 (4): 203–15. doi:10.1007/s11033-005-1407-8. PMID 15663004. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Schwartz LM, Woloshin S, Birkmeyer JD (2005). "How do elderly patients decide where to go for major surgery? Telephone interview survey". BMJ 331 (7520): 821. doi:10.1136/bmj.38614.449016.DE. PMC 1246083. PMID 16192286. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1246083. 
• Boumber YA, Kondo Y, Chen X, et al. (2007). "RIL, a LIM gene on 5q31, is silenced by methylation in cancer and sensitizes cancer cells to apoptosis". Cancer Res. 67 (5): 1997–2005. doi:10.1158/0008-5472.CAN-06-3093. PMID 17332327.