PTPN13

Protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase), also known as PTPN13, is a human gene.cite web | title = Entrez Gene: PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5783| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as IkappaBalpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.cite web | title = Entrez Gene: PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5783| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sato T, Irie S, Kitada S, Reed JC |title=FAP-1: a protein tyrosine phosphatase that associates with Fas. |journal=Science |volume=268 |issue= 5209 |pages= 411–5 |year= 1995 |pmid= 7536343 |doi=
*cite journal | author=Saras J, Claesson-Welsh L, Heldin CH, Gonez LJ |title=Cloning and characterization of PTPL1, a protein tyrosine phosphatase with similarities to cytoskeletal-associated proteins. |journal=J. Biol. Chem. |volume=269 |issue= 39 |pages= 24082–9 |year= 1994 |pmid= 7929060 |doi=
*cite journal | author=Banville D, Ahmad S, Stocco R, Shen SH |title=A novel protein-tyrosine phosphatase with homology to both the cytoskeletal proteins of the band 4.1 family and junction-associated guanylate kinases. |journal=J. Biol. Chem. |volume=269 |issue= 35 |pages= 22320–7 |year= 1994 |pmid= 8071359 |doi=
*cite journal | author=Maekawa K, Imagawa N, Nagamatsu M, Harada S |title=Molecular cloning of a novel protein-tyrosine phosphatase containing a membrane-binding domain and GLGF repeats. |journal=FEBS Lett. |volume=337 |issue= 2 |pages= 200–6 |year= 1994 |pmid= 8287977 |doi=
*cite journal | author=Inazawa J, Ariyama T, Abe T, "et al." |title=PTPN13, a fas-associated protein tyrosine phosphatase, is located on the long arm of chromosome 4 at band q21.3. |journal=Genomics |volume=31 |issue= 2 |pages= 240–2 |year= 1997 |pmid= 8824809 |doi= 10.1006/geno.1996.0039
*cite journal | author=Yanagisawa J, Takahashi M, Kanki H, "et al." |title=The molecular interaction of Fas and FAP-1. A tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8539–45 |year= 1997 |pmid= 9079683 |doi=
*cite journal | author=Saras J, Engström U, Góñez LJ, Heldin CH |title=Characterization of the interactions between PDZ domains of the protein-tyrosine phosphatase PTPL1 and the carboxyl-terminal tail of Fas. |journal=J. Biol. Chem. |volume=272 |issue= 34 |pages= 20979–81 |year= 1997 |pmid= 9261095 |doi=
*cite journal | author=Saras J, Franzén P, Aspenström P, "et al." |title=A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24333–8 |year= 1997 |pmid= 9305890 |doi=
*cite journal | author=Ekiel I, Banville D, Shen SH, "et al." |title=Main-chain signal assignment for the PDZ2 domain from human protein tyrosine phosphatase hPTP1E and its complex with a C-terminal peptide from the Fas receptor. |journal=J. Biomol. NMR |volume=12 |issue= 3 |pages= 455–6 |year= 1999 |pmid= 9835052 |doi=
*cite journal | author=Maekawa K, Imagawa N, Naito A, "et al." |title=Association of protein-tyrosine phosphatase PTP-BAS with the transcription-factor-inhibitory protein IkappaBalpha through interaction between the PDZ1 domain and ankyrin repeats. |journal=Biochem. J. |volume=337 ( Pt 2) |issue= |pages= 179–84 |year= 1999 |pmid= 9882613 |doi=
*cite journal | author=Lin D, Gish GD, Songyang Z, Pawson T |title=The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif. |journal=J. Biol. Chem. |volume=274 |issue= 6 |pages= 3726–33 |year= 1999 |pmid= 9920925 |doi=
*cite journal | author=Murthy KK, Clark K, Fortin Y, "et al." |title=ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E. |journal=J. Biol. Chem. |volume=274 |issue= 29 |pages= 20679–87 |year= 1999 |pmid= 10400701 |doi=
*cite journal | author=Cuppen E, van Ham M, Pepers B, "et al." |title=Identification and molecular characterization of BP75, a novel bromodomain-containing protein. |journal=FEBS Lett. |volume=459 |issue= 3 |pages= 291–8 |year= 1999 |pmid= 10526152 |doi=
*cite journal | author=Irie S, Hachiya T, Rabizadeh S, "et al." |title=Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation. |journal=FEBS Lett. |volume=460 |issue= 2 |pages= 191–8 |year= 1999 |pmid= 10544233 |doi=
*cite journal | author=Lee SH, Shin MS, Park WS, "et al." |title=Immunohistochemical localization of FAP-1, an inhibitor of Fas-mediated apoptosis, in normal and neoplastic human tissues. |journal=APMIS |volume=107 |issue= 12 |pages= 1101–8 |year= 2000 |pmid= 10660140 |doi=
*cite journal | author=Kozlov G, Gehring K, Ekiel I |title=Solution structure of the PDZ2 domain from human phosphatase hPTP1E and its interactions with C-terminal peptides from the Fas receptor. |journal=Biochemistry |volume=39 |issue= 10 |pages= 2572–80 |year= 2000 |pmid= 10704206 |doi=
*cite journal | author=Cuppen E, van Ham M, Wansink DG, "et al." |title=The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL. |journal=Eur. J. Cell Biol. |volume=79 |issue= 4 |pages= 283–93 |year= 2000 |pmid= 10826496 |doi=
*cite journal | author=Erdmann KS, Kuhlmann J, Lessmann V, "et al." |title=The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain. |journal=Oncogene |volume=19 |issue= 34 |pages= 3894–901 |year= 2000 |pmid= 10951583 |doi= 10.1038/sj.onc.1203725
*cite journal | author=Nakai Y, Irie S, Sato TA |title=Identification of IkappaBalpha as a substrate of Fas-associated phosphatase-1. |journal=Eur. J. Biochem. |volume=267 |issue= 24 |pages= 7170–5 |year= 2001 |pmid= 11106428 |doi=
*cite journal | author=Gross C, Heumann R, Erdmann KS |title=The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif. |journal=FEBS Lett. |volume=496 |issue= 2-3 |pages= 101–4 |year= 2001 |pmid= 11356191 |doi=

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