Vasodilator-stimulated phosphoprotein

Vasodilator-stimulated phosphoprotein

Vasodilator-stimulated phosphoprotein, also known as VASP, is a human gene.cite web | title = Entrez Gene: VASP vasodilator-stimulated phosphoprotein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7408| accessdate = ]

PBB_Summary
section_title =
summary_text = Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.cite web | title = Entrez Gene: VASP vasodilator-stimulated phosphoprotein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7408| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Reinhard M, Halbrügge M, Scheer U, "et al." |title=The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts. |journal=EMBO J. |volume=11 |issue= 6 |pages= 2063–70 |year= 1992 |pmid= 1318192 |doi=
*cite journal | author=Halbrügge M, Eigenthaler M, Polke C, Walter U |title=Protein phosphorylation regulated by cyclic nucleotide-dependent protein kinases in cell extracts and in intact human lymphocytes. |journal=Cell. Signal. |volume=4 |issue= 2 |pages= 189–99 |year= 1992 |pmid= 1319722 |doi=
*cite journal | author=Reinhard M, Jouvenal K, Tripier D, Walter U |title=Identification, purification, and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator-stimulated phosphoprotein). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 17 |pages= 7956–60 |year= 1995 |pmid= 7644520 |doi=
*cite journal | author=Reinhard M, Giehl K, Abel K, "et al." |title=The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins. |journal=EMBO J. |volume=14 |issue= 8 |pages= 1583–9 |year= 1995 |pmid= 7737110 |doi=
*cite journal | author=Haffner C, Jarchau T, Reinhard M, "et al." |title=Molecular cloning, structural analysis and functional expression of the proline-rich focal adhesion and microfilament-associated protein VASP. |journal=EMBO J. |volume=14 |issue= 1 |pages= 19–27 |year= 1995 |pmid= 7828592 |doi=
*cite journal | author=Horstrup K, Jablonka B, Hönig-Liedl P, "et al." |title=Phosphorylation of focal adhesion vasodilator-stimulated phosphoprotein at Ser157 in intact human platelets correlates with fibrinogen receptor inhibition. |journal=Eur. J. Biochem. |volume=225 |issue= 1 |pages= 21–7 |year= 1994 |pmid= 7925440 |doi=
*cite journal | author=Butt E, Abel K, Krieger M, "et al." |title=cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets. |journal=J. Biol. Chem. |volume=269 |issue= 20 |pages= 14509–17 |year= 1994 |pmid= 8182057 |doi=
*cite journal | author=Zimmer M, Fink T, Fischer L, "et al." |title=Cloning of the VASP (vasodilator-stimulated phosphoprotein) genes in human and mouse: structure, sequence, and chromosomal localization. |journal=Genomics |volume=36 |issue= 2 |pages= 227–33 |year= 1997 |pmid= 8812448 |doi= 10.1006/geno.1996.0457
*cite journal | author=Laurent V, Loisel TP, Harbeck B, "et al." |title=Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes. |journal=J. Cell Biol. |volume=144 |issue= 6 |pages= 1245–58 |year= 1999 |pmid= 10087267 |doi=
*cite journal | author=Bachmann C, Fischer L, Walter U, Reinhard M |title=The EVH2 domain of the vasodilator-stimulated phosphoprotein mediates tetramerization, F-actin binding, and actin bundle formation. |journal=J. Biol. Chem. |volume=274 |issue= 33 |pages= 23549–57 |year= 1999 |pmid= 10438535 |doi=
*cite journal | author=Petit MM, Fradelizi J, Golsteyn RM, "et al." |title=LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity. |journal=Mol. Biol. Cell |volume=11 |issue= 1 |pages= 117–29 |year= 2000 |pmid= 10637295 |doi=
*cite journal | author=Krause M, Sechi AS, Konradt M, "et al." |title=Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. |journal=J. Cell Biol. |volume=149 |issue= 1 |pages= 181–94 |year= 2000 |pmid= 10747096 |doi=
*cite journal | author=Drees B, Friederich E, Fradelizi J, "et al." |title=Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22503–11 |year= 2000 |pmid= 10801818 |doi= 10.1074/jbc.M001698200
*cite journal | author=Smolenski A, Poller W, Walter U, Lohmann SM |title=Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25723–32 |year= 2000 |pmid= 10851246 |doi= 10.1074/jbc.M909632199
*cite journal | author=Harbeck B, Hüttelmaier S, Schluter K, "et al." |title=Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin. |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 30817–25 |year= 2000 |pmid= 10882740 |doi= 10.1074/jbc.M005066200
*cite journal | author=Burkhardt M, Glazova M, Gambaryan S, "et al." |title=KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells. |journal=J. Biol. Chem. |volume=275 |issue= 43 |pages= 33536–41 |year= 2000 |pmid= 10922374 |doi= 10.1074/jbc.M005670200
*cite journal | author=Ball LJ, Kühne R, Hoffmann B, "et al." |title=Dual epitope recognition by the VASP EVH1 domain modulates polyproline ligand specificity and binding affinity. |journal=EMBO J. |volume=19 |issue= 18 |pages= 4903–14 |year= 2000 |pmid= 10990454 |doi= 10.1093/emboj/19.18.4903
*cite journal | author=Bearer EL, Prakash JM, Manchester RD, Allen PG |title=VASP protects actin filaments from gelsolin: an in vitro study with implications for platelet actin reorganizations. |journal=Cell Motil. Cytoskeleton |volume=47 |issue= 4 |pages= 351–64 |year= 2001 |pmid= 11093254 |doi= 10.1002/1097-0169(200012)47:4<351::AID-CM8>3.0.CO;2-8 |doilabel=10.1002/1097-0169(200012)47:4351::AID-CM83.0.CO;2-8
*cite journal | author=Lawrence DW, Pryzwansky KB |title=The vasodilator-stimulated phosphoprotein is regulated by cyclic GMP-dependent protein kinase during neutrophil spreading. |journal=J. Immunol. |volume=166 |issue= 9 |pages= 5550–6 |year= 2001 |pmid= 11313394 |doi=
*cite journal | author=Castellano F, Le Clainche C, Patin D, "et al." |title=A WASp-VASP complex regulates actin polymerization at the plasma membrane. |journal=EMBO J. |volume=20 |issue= 20 |pages= 5603–14 |year= 2001 |pmid= 11598004 |doi= 10.1093/emboj/20.20.5603

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