FBLIM1

Filamin binding LIM protein 1, also known as FBLIM1, is a human gene.cite web | title = Entrez Gene: FBLIM1 filamin binding LIM protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54751| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: FBLIM1 filamin binding LIM protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54751| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wu C |title=Migfilin and its binding partners: from cell biology to human diseases. |journal=J. Cell. Sci. |volume=118 |issue= Pt 4 |pages= 659–64 |year= 2005 |pmid= 15701922 |doi= 10.1242/jcs.01639
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Takafuta T, Saeki M, Fujimoto TT, "et al." |title=A new member of the LIM protein family binds to filamin B and localizes at stress fibers. |journal=J. Biol. Chem. |volume=278 |issue= 14 |pages= 12175–81 |year= 2003 |pmid= 12496242 |doi= 10.1074/jbc.M209339200
*cite journal | author=Tu Y, Wu S, Shi X, "et al." |title=Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. |journal=Cell |volume=113 |issue= 1 |pages= 37–47 |year= 2003 |pmid= 12679033 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Akazawa H, Kudoh S, Mochizuki N, "et al." |title=A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5. |journal=J. Cell Biol. |volume=164 |issue= 3 |pages= 395–405 |year= 2004 |pmid= 14757752 |doi= 10.1083/jcb.200309159
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Gkretsi V, Zhang Y, Tu Y, "et al." |title=Physical and functional association of migfilin with cell-cell adhesions. |journal=J. Cell. Sci. |volume=118 |issue= Pt 4 |pages= 697–710 |year= 2005 |pmid= 15671069 |doi= 10.1242/jcs.01638
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Oh JH, Yang JO, Hahn Y, "et al." |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2
*cite journal | author=Zhang Y, Tu Y, Gkretsi V, Wu C |title=Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration. |journal=J. Biol. Chem. |volume=281 |issue= 18 |pages= 12397–407 |year= 2006 |pmid= 16531412 |doi= 10.1074/jbc.M512107200
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Papachristou DJ, Gkretsi V, Tu Y, "et al." |title=Increased cytoplasmic level of migfilin is associated with higher grades of human leiomyosarcoma. |journal=Histopathology |volume=51 |issue= 4 |pages= 499–508 |year= 2007 |pmid= 17711449 |doi= 10.1111/j.1365-2559.2007.02791.x

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