CDH1 (gene)

CDH1 (gene)

Cadherin 1, type 1, E-cadherin (epithelial), also known as CDH1, is a human gene. CDH1 has also been designated as CD324 (cluster of differentiation 324).

It is a tumor suppressor gene.cite journal |author=Semb H, Christofori G |title=The tumor-suppressor function of E-cadherin |journal=Am. J. Hum. Genet. |volume=63 |issue=6 |pages=1588–93 |year=1998 |month=December |pmid=9837810 |pmc=1377629 |doi=10.1086/302173 |url=] cite journal |author=Wong AS, Gumbiner BM |title=Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin |journal=J. Cell Biol. |volume=161 |issue=6 |pages=1191–203 |year=2003 |month=June |pmid=12810698 |pmc=2173007 |doi=10.1083/jcb.200212033 |url=]

section_title =
summary_text = This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [cite web | title = Entrez Gene: CDH1 cadherin 1, type 1, E-cadherin (epithelial)| url =| accessdate = ]

ee also

* Cluster of differentiation


Further reading

citations =
*cite journal | author=Berx G, Becker KF, Höfler H, van Roy F |title=Mutations of the human E-cadherin (CDH1) gene. |journal=Hum. Mutat. |volume=12 |issue= 4 |pages= 226–37 |year= 1998 |pmid= 9744472 |doi= 10.1002/(SICI)1098-1004(1998)12:4<226::AID-HUMU2>3.0.CO;2-D |doilabel=10.1002/(SICI)1098-1004(1998)12:4226::AID-HUMU23.0.CO;2-D
*cite journal | author=Wijnhoven BP, Dinjens WN, Pignatelli M |title=E-cadherin-catenin cell-cell adhesion complex and human cancer. |journal=The British journal of surgery |volume=87 |issue= 8 |pages= 992–1005 |year= 2000 |pmid= 10931041 |doi= 10.1046/j.1365-2168.2000.01513.x
*cite journal | author=Beavon IR |title=The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation. |journal=Eur. J. Cancer |volume=36 |issue= 13 Spec No |pages= 1607–20 |year= 2000 |pmid= 10959047 |doi=
*cite journal | author=Wilson PD |title=Polycystin: new aspects of structure, function, and regulation. |journal=J. Am. Soc. Nephrol. |volume=12 |issue= 4 |pages= 834–45 |year= 2001 |pmid= 11274246 |doi=
*cite journal | author=Chun YS, Lindor NM, Smyrk TC, "et al." |title=Germline E-cadherin gene mutations: is prophylactic total gastrectomy indicated? |journal=Cancer |volume=92 |issue= 1 |pages= 181–7 |year= 2001 |pmid= 11443625 |doi=
*cite journal | author=Hazan RB, Qiao R, Keren R, "et al." |title=Cadherin switch in tumor progression. |journal=Ann. N. Y. Acad. Sci. |volume=1014 |issue= |pages= 155–63 |year= 2004 |pmid= 15153430 |doi=
*cite journal | author=Bryant DM, Stow JL |title=The ins and outs of E-cadherin trafficking. |journal=Trends Cell Biol. |volume=14 |issue= 8 |pages= 427–34 |year= 2005 |pmid= 15308209 |doi= 10.1016/j.tcb.2004.07.007
*cite journal | author=Wang HD, Ren J, Zhang L |title=CDH1 germline mutation in hereditary gastric carcinoma. |journal=World J. Gastroenterol. |volume=10 |issue= 21 |pages= 3088–93 |year= 2004 |pmid= 15457549 |doi=
*cite journal | author=Reynolds AB, Carnahan RH |title=Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer. |journal=Semin. Cell Dev. Biol. |volume=15 |issue= 6 |pages= 657–63 |year= 2005 |pmid= 15561585 |doi= 10.1016/j.semcdb.2004.09.003
*cite journal | author=Moran CJ, Joyce M, McAnena OJ |title=CDH1 associated gastric cancer: a report of a family and review of the literature. |journal=Eur J Surg Oncol |volume=31 |issue= 3 |pages= 259–64 |year= 2005 |pmid= 15780560 |doi= 10.1016/j.ejso.2004.12.010
*cite journal | author=Georgolios A, Batistatou A, Manolopoulos L, Charalabopoulos K |title=Role and expression patterns of E-cadherin in head and neck squamous cell carcinoma (HNSCC). |journal=J. Exp. Clin. Cancer Res. |volume=25 |issue= 1 |pages= 5–14 |year= 2006 |pmid= 16761612 |doi=

External links


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