PTPN2

Protein tyrosine phosphatase, non-receptor type 2, also known as PTPN2, is a human gene.cite web | title = Entrez Gene: PTPN2 protein tyrosine phosphatase, non-receptor type 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5771| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported.cite web | title = Entrez Gene: PTPN2 protein tyrosine phosphatase, non-receptor type 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5771| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Mosinger B, Tillmann U, Westphal H, Tremblay ML |title=Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 2 |pages= 499–503 |year= 1992 |pmid= 1731319 |doi=
*cite journal | author=Swarup G, Kamatkar S, Radha V, Rema V |title=Molecular cloning and expression of a protein-tyrosine phosphatase showing homology with transcription factors Fos and Jun. |journal=FEBS Lett. |volume=280 |issue= 1 |pages= 65–9 |year= 1991 |pmid= 1849097 |doi=
*cite journal | author=Brown-Shimer S, Johnson KA, Lawrence JB, "et al." |title=Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 13 |pages= 5148–52 |year= 1990 |pmid= 2164224 |doi=
*cite journal | author=Cool DE, Tonks NK, Charbonneau H, "et al." |title=cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 14 |pages= 5257–61 |year= 1989 |pmid= 2546150 |doi=
*cite journal | author=Lorenzen JA, Dadabay CY, Fischer EH |title=COOH-terminal sequence motifs target the T cell protein tyrosine phosphatase to the ER and nucleus. |journal=J. Cell Biol. |volume=131 |issue= 3 |pages= 631–43 |year= 1995 |pmid= 7593185 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Johnson CV, Cool DE, Glaccum MB, "et al." |title=Isolation and mapping of human T-cell protein tyrosine phosphatase sequences: localization of genes and pseudogenes discriminated using fluorescence hybridization with genomic versus cDNA probes. |journal=Genomics |volume=16 |issue= 3 |pages= 619–29 |year= 1993 |pmid= 8325634 |doi= 10.1006/geno.1993.1239
*cite journal | author=Tiganis T, Flint AJ, Adam SA, Tonks NK |title=Association of the T-cell protein tyrosine phosphatase with nuclear import factor p97. |journal=J. Biol. Chem. |volume=272 |issue= 34 |pages= 21548–57 |year= 1997 |pmid= 9261175 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Tiganis T, Bennett AM, Ravichandran KS, Tonks NK |title=Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase. |journal=Mol. Cell. Biol. |volume=18 |issue= 3 |pages= 1622–34 |year= 1998 |pmid= 9488479 |doi=
*cite journal | author=Tiganis T, Kemp BE, Tonks NK |title=The protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and phosphatidylinositol 3-kinase-dependent signaling. |journal=J. Biol. Chem. |volume=274 |issue= 39 |pages= 27768–75 |year= 1999 |pmid= 10488121 |doi=
*cite journal | author=Aoki N, Matsuda T |title=A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus. |journal=Mol. Endocrinol. |volume=16 |issue= 1 |pages= 58–69 |year= 2002 |pmid= 11773439 |doi=
*cite journal | author=Iversen LF, Moller KB, Pedersen AK, "et al." |title=Structure determination of T cell protein-tyrosine phosphatase. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19982–90 |year= 2002 |pmid= 11907034 |doi= 10.1074/jbc.M200567200
*cite journal | author=Simoncic PD, Lee-Loy A, Barber DL, "et al." |title=The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. |journal=Curr. Biol. |volume=12 |issue= 6 |pages= 446–53 |year= 2002 |pmid= 11909529 |doi=
*cite journal | author=ten Hoeve J, de Jesus Ibarra-Sanchez M, Fu Y, "et al." |title=Identification of a nuclear Stat1 protein tyrosine phosphatase. |journal=Mol. Cell. Biol. |volume=22 |issue= 16 |pages= 5662–8 |year= 2002 |pmid= 12138178 |doi=
*cite journal | author=Zhu W, Mustelin T, David M |title=Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 35787–90 |year= 2002 |pmid= 12171910 |doi= 10.1074/jbc.C200346200
*cite journal | author=Yamamoto T, Sekine Y, Kashima K, "et al." |title=The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 4 |pages= 811–7 |year= 2002 |pmid= 12359225 |doi=
*cite journal | author=Gupta S, Radha V, Sudhakar Ch, Swarup G |title=A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis. |journal=FEBS Lett. |volume=532 |issue= 1-2 |pages= 61–6 |year= 2003 |pmid= 12459463 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Galic S, Klingler-Hoffmann M, Fodero-Tavoletti MT, "et al." |title=Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP. |journal=Mol. Cell. Biol. |volume=23 |issue= 6 |pages= 2096–108 |year= 2003 |pmid= 12612081 |doi=

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