PSMD8

PSMD8

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8, also known as PSMD8, is a human gene.cite web | title = Entrez Gene: PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5714| accessdate = ]

PBB_Summary
section_title =
summary_text = The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1.cite web | title = Entrez Gene: PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5714| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
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*cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281–3 |year= 2003 |pmid= 12914693 |doi=
*cite journal | author=Kominami K, DeMartino GN, Moomaw CR, "et al." |title=Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae. |journal=EMBO J. |volume=14 |issue= 13 |pages= 3105–15 |year= 1995 |pmid= 7621825 |doi=
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