PTP4A3

Protein tyrosine phosphatase type IVA, member 3, also known as PTP4A3, is a human gene.cite web | title = Entrez Gene: PTP4A3 protein tyrosine phosphatase type IVA, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11156| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist.cite web | title = Entrez Gene: PTP4A3 protein tyrosine phosphatase type IVA, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11156| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zeng Q, Hong W, Tan YH |title=Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1. |journal=Biochem. Biophys. Res. Commun. |volume=244 |issue= 2 |pages= 421–7 |year= 1998 |pmid= 9514946 |doi= 10.1006/bbrc.1998.8291
*cite journal | author=Dayton MA, Knobloch TJ |title=Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38. |journal=Receptors & signal transduction |volume=7 |issue= 4 |pages= 241–56 |year= 1998 |pmid= 9633825 |doi=
*cite journal | author=Zeng Q, Si X, Horstmann H, "et al." |title=Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome. |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21444–52 |year= 2000 |pmid= 10747914 |doi= 10.1074/jbc.M000453200
*cite journal | author=Matter WF, Estridge T, Zhang C, "et al." |title=Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling. |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 5 |pages= 1061–8 |year= 2001 |pmid= 11355880 |doi= 10.1006/bbrc.2001.4881
*cite journal | author=Saha S, Bardelli A, Buckhaults P, "et al." |title=A phosphatase associated with metastasis of colorectal cancer. |journal=Science |volume=294 |issue= 5545 |pages= 1343–6 |year= 2001 |pmid= 11598267 |doi= 10.1126/science.1065817
*cite journal | author=Wang J, Kirby CE, Herbst R |title=The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46659–68 |year= 2003 |pmid= 12235145 |doi= 10.1074/jbc.M206407200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Pathak MK, Dhawan D, Lindner DJ, "et al." |title=Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. |journal=Mol. Cancer Ther. |volume=1 |issue= 14 |pages= 1255–64 |year= 2003 |pmid= 12516958 |doi=
*cite journal | author=Zeng Q, Dong JM, Guo K, "et al." |title=PRL-3 and PRL-1 promote cell migration, invasion, and metastasis. |journal=Cancer Res. |volume=63 |issue= 11 |pages= 2716–22 |year= 2003 |pmid= 12782572 |doi=
*cite journal | author=Bardelli A, Saha S, Sager JA, "et al." |title=PRL-3 expression in metastatic cancers. |journal=Clin. Cancer Res. |volume=9 |issue= 15 |pages= 5607–15 |year= 2004 |pmid= 14654542 |doi=
*cite journal | author=Kozlov G, Cheng J, Ziomek E, "et al." |title=Structural insights into molecular function of the metastasis-associated phosphatase PRL-3. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11882–9 |year= 2004 |pmid= 14704153 |doi= 10.1074/jbc.M312905200
*cite journal | author=Kim KA, Song JS, Jee J, "et al." |title=Structure of human PRL-3, the phosphatase associated with cancer metastasis. |journal=FEBS Lett. |volume=565 |issue= 1-3 |pages= 181–7 |year= 2004 |pmid= 15135076 |doi= 10.1016/j.febslet.2004.03.062
*cite journal | author=Wu X, Zeng H, Zhang X, "et al." |title=Phosphatase of regenerating liver-3 promotes motility and metastasis of mouse melanoma cells. |journal=Am. J. Pathol. |volume=164 |issue= 6 |pages= 2039–54 |year= 2004 |pmid= 15161639 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kato H, Semba S, Miskad UA, "et al." |title=High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases. |journal=Clin. Cancer Res. |volume=10 |issue= 21 |pages= 7318–28 |year= 2005 |pmid= 15534108 |doi= 10.1158/1078-0432.CCR-04-0485
*cite journal | author=Li J, Guo K, Koh VW, "et al." |title=Generation of PRL-3- and PRL-1-specific monoclonal antibodies as potential diagnostic markers for cancer metastases. |journal=Clin. Cancer Res. |volume=11 |issue= 6 |pages= 2195–204 |year= 2005 |pmid= 15788667 |doi= 10.1158/1078-0432.CCR-04-1984
*cite journal | author=Polato F, Codegoni A, Fruscio R, "et al." |title=PRL-3 phosphatase is implicated in ovarian cancer growth. |journal=Clin. Cancer Res. |volume=11 |issue= 19 Pt 1 |pages= 6835–9 |year= 2006 |pmid= 16203771 |doi= 10.1158/1078-0432.CCR-04-2357
*cite journal | author=Peng L, Jin G, Wang L, "et al." |title=Identification of integrin alpha1 as an interacting protein of protein tyrosine phosphatase PRL-3. |journal=Biochem. Biophys. Res. Commun. |volume=342 |issue= 1 |pages= 179–83 |year= 2006 |pmid= 16472776 |doi= 10.1016/j.bbrc.2006.01.102
*cite journal | author=Rouleau C, Roy A, St Martin T, "et al." |title=Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function. |journal=Mol. Cancer Ther. |volume=5 |issue= 2 |pages= 219–29 |year= 2006 |pmid= 16505094 |doi= 10.1158/1535-7163.MCT-05-0289
*cite journal | author=Radke I, Götte M, Kersting C, "et al." |title=Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer. |journal=Br. J. Cancer |volume=95 |issue= 3 |pages= 347–54 |year= 2006 |pmid= 16832410 |doi= 10.1038/sj.bjc.6603261

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