TREX1

Three prime repair exonuclease 1, also known as TREX1, is a human gene.cite web | title = Entrez Gene: TREX1 three prime repair exonuclease 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11277| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: TREX1 three prime repair exonuclease 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11277| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tolmie JL, Shillito P, Hughes-Benzie R, Stephenson JB |title=The Aicardi-Goutières syndrome (familial, early onset encephalopathy with calcifications of the basal ganglia and chronic cerebrospinal fluid lymphocytosis). |journal=J. Med. Genet. |volume=32 |issue= 11 |pages= 881–4 |year= 1996 |pmid= 8592332 |doi=
*cite journal | author=Black DN, Watters GV, Andermann E, "et al." |title=Encephalitis among Cree children in northern Quebec. |journal=Ann. Neurol. |volume=24 |issue= 4 |pages= 483–9 |year= 1989 |pmid= 3239950 |doi= 10.1002/ana.410240402
*cite journal | author=Perrino FW, Miller H, Ealey KA |title=Identification of a 3'-->5'-exonuclease that removes cytosine arabinoside monophosphate from 3' termini of DNA. |journal=J. Biol. Chem. |volume=269 |issue= 23 |pages= 16357–63 |year= 1994 |pmid= 8206943 |doi=
*cite journal | author=Goutières F, Aicardi J, Barth PG, Lebon P |title=Aicardi-Goutières syndrome: an update and results of interferon-alpha studies. |journal=Ann. Neurol. |volume=44 |issue= 6 |pages= 900–7 |year= 1999 |pmid= 9851434 |doi= 10.1002/ana.410440608
*cite journal | author=Mazur DJ, Perrino FW |title=Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. |journal=J. Biol. Chem. |volume=274 |issue= 28 |pages= 19655–60 |year= 1999 |pmid= 10391904 |doi=
*cite journal | author=Höss M, Robins P, Naven TJ, "et al." |title=A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein. |journal=EMBO J. |volume=18 |issue= 13 |pages= 3868–75 |year= 1999 |pmid= 10393201 |doi= 10.1093/emboj/18.13.3868
*cite journal | author=Crow YJ, Jackson AP, Roberts E, "et al." |title=Aicardi-Goutières syndrome displays genetic heterogeneity with one locus (AGS1) on chromosome 3p21. |journal=Am. J. Hum. Genet. |volume=67 |issue= 1 |pages= 213–21 |year= 2000 |pmid= 10827106 |doi=
*cite journal | author=Mazur DJ, Perrino FW |title=Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 14718–27 |year= 2001 |pmid= 11278605 |doi= 10.1074/jbc.M010051200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Crow YJ, Black DN, Ali M, "et al." |title=Cree encephalitis is allelic with Aicardi-Goutiéres syndrome: implications for the pathogenesis of disorders of interferon alpha metabolism. |journal=J. Med. Genet. |volume=40 |issue= 3 |pages= 183–7 |year= 2003 |pmid= 12624136 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Unsal-Kaçmaz K, Mullen TE, Kaufmann WK, Sancar A |title=Coupling of human circadian and cell cycles by the timeless protein. |journal=Mol. Cell. Biol. |volume=25 |issue= 8 |pages= 3109–16 |year= 2005 |pmid= 15798197 |doi= 10.1128/MCB.25.8.3109-3116.2005
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Yoshioka K, Yoshioka Y, Hsieh P |title=ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. |journal=Mol. Cell |volume=22 |issue= 4 |pages= 501–10 |year= 2006 |pmid= 16713580 |doi= 10.1016/j.molcel.2006.04.023
*cite journal | author=Chowdhury D, Beresford PJ, Zhu P, "et al." |title=The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. |journal=Mol. Cell |volume=23 |issue= 1 |pages= 133–42 |year= 2006 |pmid= 16818237 |doi= 10.1016/j.molcel.2006.06.005
*cite journal | author=Crow YJ, Hayward BE, Parmar R, "et al." |title=Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus. |journal=Nat. Genet. |volume=38 |issue= 8 |pages= 917–20 |year= 2006 |pmid= 16845398 |doi= 10.1038/ng1845
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026

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