TREX2

Three prime repair exonuclease 2, also known as TREX2, is a human gene.cite web | title = Entrez Gene: TREX2 three prime repair exonuclease 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11219| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity.cite web | title = Entrez Gene: TREX2 three prime repair exonuclease 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11219| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Shevelev IV, Hübscher U |title=The 3' 5' exonucleases. |journal=Nat. Rev. Mol. Cell Biol. |volume=3 |issue= 5 |pages= 364–76 |year= 2002 |pmid= 11988770 |doi= 10.1038/nrm804
*cite journal | author=Esposito T, Ciccodicola A, Flagiello L, "et al." |title=Expressed STSs and transcription of human Xq28. |journal=Gene |volume=187 |issue= 2 |pages= 185–91 |year= 1997 |pmid= 9099879 |doi=
*cite journal | author=Mazur DJ, Perrino FW |title=Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. |journal=J. Biol. Chem. |volume=274 |issue= 28 |pages= 19655–60 |year= 1999 |pmid= 10391904 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Li T, Duan W, Yang H, "et al." |title=Identification of two proteins, S14 and UIP1, that interact with UCH37. |journal=FEBS Lett. |volume=488 |issue= 3 |pages= 201–5 |year= 2001 |pmid= 11163772 |doi=
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Mazur DJ, Perrino FW |title=Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 14718–27 |year= 2001 |pmid= 11278605 |doi= 10.1074/jbc.M010051200
*cite journal | author=Mazur DJ, Perrino FW |title=Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17022–9 |year= 2001 |pmid= 11279105 |doi= 10.1074/jbc.M100623200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Shevelev IV, Beliakova NV, Kravetskaia TP, Krutiakov VM |title= [The correcting role of autonomous 3'-->5' exonucleases in mammalian multienzyme DNA polymerase complexes] |journal=Mol. Biol. (Mosk.) |volume=36 |issue= 6 |pages= 1055–61 |year= 2003 |pmid= 12500544 |doi=
*cite journal | author=Shevelev IV, Ramadan K, Hübscher U |title=The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy. |journal=ScientificWorldJournal |volume=2 |issue= |pages= 275–81 |year= 2004 |pmid= 12806015 |doi= 10.1100/tsw.2002.99
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Perrino FW, Krol A, Harvey S, "et al." |title=Sequence variants in the 3'-->5' deoxyribonuclease TREX2: identification in a genetic screen and effects on catalysis by the recombinant proteins. |journal=Adv. Enzyme Regul. |volume=44 |issue= |pages= 37–49 |year= 2005 |pmid= 15581481 |doi= 10.1016/j.advenzreg.2003.11.010
*cite journal | author=Perrino FW, Harvey S, McMillin S, Hollis T |title=The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis. |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 15212–8 |year= 2005 |pmid= 15661738 |doi= 10.1074/jbc.M500108200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Hahn Y, Lee B |title=Human-specific nonsense mutations identified by genome sequence comparisons. |journal=Hum. Genet. |volume=119 |issue= 1-2 |pages= 169–78 |year= 2007 |pmid= 16395595 |doi= 10.1007/s00439-005-0125-6
*cite journal | author=Chen MJ, Ma SM, Dumitrache LC, Hasty P |title=Biochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2. |journal=Nucleic Acids Res. |volume=35 |issue= 8 |pages= 2682–94 |year= 2007 |pmid= 17426129 |doi= 10.1093/nar/gkm151

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes