CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae), also known as CDC14B, is a human gene.cite web | title = Entrez Gene: CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8555| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.cite web | title = Entrez Gene: CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8555| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Li L, Ernsting BR, Wishart MJ, "et al." |title=A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. |journal=J. Biol. Chem. |volume=272 |issue= 47 |pages= 29403–6 |year= 1997 |pmid= 9367992 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Li L, Ljungman M, Dixon JE |title=The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53. |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2410–4 |year= 2000 |pmid= 10644693 |doi=
*cite journal | author=Mailand N, Lukas C, Kaiser BK, "et al." |title=Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. |journal=Nat. Cell Biol. |volume=4 |issue= 4 |pages= 317–22 |year= 2002 |pmid= 11901424 |doi= 10.1038/ncb777
*cite journal | author=Kaiser BK, Zimmerman ZA, Charbonneau H, Jackson PK |title=Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase. |journal=Mol. Biol. Cell |volume=13 |issue= 7 |pages= 2289–300 |year= 2003 |pmid= 12134069 |doi= 10.1091/mbc.01-11-0535
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Dryden SC, Nahhas FA, Nowak JE, "et al." |title=Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. |journal=Mol. Cell. Biol. |volume=23 |issue= 9 |pages= 3173–85 |year= 2003 |pmid= 12697818 |doi=
*cite journal | author=Gray CH, Good VM, Tonks NK, Barford D |title=The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase. |journal=EMBO J. |volume=22 |issue= 14 |pages= 3524–35 |year= 2003 |pmid= 12853468 |doi= 10.1093/emboj/cdg348
*cite journal | author=Nalepa G, Harper JW |title=Visualization of a highly organized intranuclear network of filaments in living mammalian cells. |journal=Cell Motil. Cytoskeleton |volume=59 |issue= 2 |pages= 94–108 |year= 2005 |pmid= 15362113 |doi= 10.1002/cm.20023
*cite journal | author=Cho HP, Liu Y, Gomez M, "et al." |title=The dual-specificity phosphatase CDC14B bundles and stabilizes microtubules. |journal=Mol. Cell. Biol. |volume=25 |issue= 11 |pages= 4541–51 |year= 2005 |pmid= 15899858 |doi= 10.1128/MCB.25.11.4541-4551.2005
*cite journal | author=Vázquez-Novelle MD, Esteban V, Bueno A, Sacristán MP |title=Functional homology among human and fission yeast Cdc14 phosphatases. |journal=J. Biol. Chem. |volume=280 |issue= 32 |pages= 29144–50 |year= 2005 |pmid= 15911625 |doi= 10.1074/jbc.M413328200
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes