PTPRT

Protein tyrosine phosphatase, receptor type, T, also known as PTPRT, is a human gene.cite web | title = Entrez Gene: PTPRT protein tyrosine phosphatase, receptor type, T| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11122| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.cite web | title = Entrez Gene: PTPRT protein tyrosine phosphatase, receptor type, T| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11122| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zhang X, Guo A, Yu J, "et al." |title=Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 10 |pages= 4060–4 |year= 2007 |pmid= 17360477 |doi= 10.1073/pnas.0611665104
*cite journal | author=Lee JW, Jeong EG, Lee SH, "et al." |title=Mutational analysis of PTPRT phosphatase domains in common human cancers. |journal=APMIS |volume=115 |issue= 1 |pages= 47–51 |year= 2007 |pmid= 17223850 |doi= 10.1111/j.1600-0463.2007.apm_554.x
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Hu YF, Zhang HL, Cai T, "et al." |title=The IA-2 interactome. |journal=Diabetologia |volume=48 |issue= 12 |pages= 2576–81 |year= 2006 |pmid= 16273344 |doi= 10.1007/s00125-005-0037-y
*cite journal | author=Wang Z, Shen D, Parsons DW, "et al." |title=Mutational analysis of the tyrosine phosphatome in colorectal cancers. |journal=Science |volume=304 |issue= 5674 |pages= 1164–6 |year= 2004 |pmid= 15155950 |doi= 10.1126/science.1096096
*cite journal | author=Besco JA, Frostholm A, Popesco MC, "et al." |title=Genomic organization and alternative splicing of the human and mouse RPTPrho genes: Correction. |journal=BMC Genomics |volume=2 |issue= 1 |pages= 5 |year= 2003 |pmid= 11814386 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Besco JA, Frostholm A, Popesco MC, "et al." |title=Genomic organization and alternative splicing of the human and mouse RPTPrho genes. |journal=BMC Genomics |volume=2 |issue= 1 |pages= 1 |year= 2003 |pmid= 11423001 |doi=
*cite journal | author=McAndrew PE, Frostholm A, White RA, "et al." |title=Identification and characterization of RPTP rho, a novel RPTP mu/kappa-like receptor protein tyrosine phosphatase whose expression is restricted to the central nervous system. |journal=Brain Res. Mol. Brain Res. |volume=56 |issue= 1-2 |pages= 9–21 |year= 1999 |pmid= 9602027 |doi=
*cite journal | author=McAndrew PE, Frostholm A, Evans JE, "et al." |title=Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic fibroblast growth factor (FGF-1) transcripts delineate a rostrocaudal boundary in the granule cell layer of the murine cerebellar cortex. |journal=J. Comp. Neurol. |volume=391 |issue= 4 |pages= 444–55 |year= 1998 |pmid= 9486824 |doi=
*cite journal | author=Ohara O, Nagase T, Ishikawa K, "et al." |title=Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. |journal=DNA Res. |volume=4 |issue= 1 |pages= 53–9 |year= 1997 |pmid= 9179496 |doi=
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=

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