PTPRE

Protein tyrosine phosphatase, receptor type, E, also known as PTPRE, is a human gene.cite web | title = Entrez Gene: PTPRE protein tyrosine phosphatase, receptor type, E| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5791| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels.cite web | title = Entrez Gene: PTPRE protein tyrosine phosphatase, receptor type, E| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5791| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Roskoski R |title=Src kinase regulation by phosphorylation and dephosphorylation. |journal=Biochem. Biophys. Res. Commun. |volume=331 |issue= 1 |pages= 1–14 |year= 2005 |pmid= 15845350 |doi= 10.1016/j.bbrc.2005.03.012
*cite journal | author=Krueger NX, Streuli M, Saito H |title=Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. |journal=EMBO J. |volume=9 |issue= 10 |pages= 3241–52 |year= 1990 |pmid= 2170109 |doi=
*cite journal | author=Adams MD, Kerlavage AR, Fleischmann RD, "et al." |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |doi=
*cite journal | author=Murakawa K, Matsubara K, Fukushima A, "et al." |title=Chromosomal assignments of 3'-directed partial cDNA sequences representing novel genes expressed in granulocytoid cells. |journal=Genomics |volume=23 |issue= 2 |pages= 379–89 |year= 1995 |pmid= 7835887 |doi= 10.1006/geno.1994.1514
*cite journal | author=Okubo K, Itoh K, Fukushima A, "et al." |title=Monitoring cell physiology by expression profiles and discovering cell type-specific genes by compiled expression profiles. |journal=Genomics |volume=30 |issue= 2 |pages= 178–86 |year= 1996 |pmid= 8586417 |doi= 10.1006/geno.1995.9887
*cite journal | author=van den Maagdenberg AM, van den Hurk HH, Weghuis D, "et al." |title=Assignment of the human protein tyrosine phosphatase epsilon (PTPRE) gene to chromosome 10q26 by fluorescence in situ hybridization. |journal=Genomics |volume=30 |issue= 1 |pages= 128–9 |year= 1996 |pmid= 8595895 |doi=
*cite journal | author=Elson A, Leder P |title=Identification of a cytoplasmic, phorbol ester-inducible isoform of protein tyrosine phosphatase epsilon. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 26 |pages= 12235–9 |year= 1996 |pmid= 8618876 |doi=
*cite journal | author=Gastier JM, Brody T, Pulido JC, "et al." |title=Development of a screening set for new (CAG/CTG)n dynamic mutations. |journal=Genomics |volume=32 |issue= 1 |pages= 75–85 |year= 1996 |pmid= 8786123 |doi= 10.1006/geno.1996.0078
*cite journal | author=Elson A, Kozak CA, Morton CC, "et al." |title=The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26. |journal=Genomics |volume=31 |issue= 3 |pages= 373–5 |year= 1997 |pmid= 8838320 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Toledano-Katchalski H, Elson A |title=The transmembranal and cytoplasmic forms of protein tyrosine phosphatase epsilon physically associate with the adaptor molecule Grb2. |journal=Oncogene |volume=18 |issue= 36 |pages= 5024–31 |year= 1999 |pmid= 10490839 |doi= 10.1038/sj.onc.1202883
*cite journal | author=Tanuma N, Nakamura K, Shima H, Kikuchi K |title=Protein-tyrosine phosphatase PTPepsilon C inhibits Jak-STAT signaling and differentiation induced by interleukin-6 and leukemia inhibitory factor in M1 leukemia cells. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 28216–21 |year= 2000 |pmid= 10859312 |doi= 10.1074/jbc.M003661200
*cite journal | author=Peretz A, Gil-Henn H, Sobko A, "et al." |title=Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon. |journal=EMBO J. |volume=19 |issue= 15 |pages= 4036–45 |year= 2000 |pmid= 10921884 |doi= 10.1093/emboj/19.15.4036
*cite journal | author=Gil-Henn H, Volohonsky G, Toledano-Katchalski H, "et al." |title=Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control. |journal=Oncogene |volume=19 |issue= 38 |pages= 4375–84 |year= 2000 |pmid= 10980613 |doi= 10.1038/sj.onc.1203790
*cite journal | author=Wabakken T, Hauge H, Finne EF, "et al." |title=Expression of human protein tyrosine phosphatase epsilon in leucocytes: a potential ERK pathway-regulating phosphatase. |journal=Scand. J. Immunol. |volume=56 |issue= 2 |pages= 195–203 |year= 2002 |pmid= 12121439 |doi=
*cite journal | author=Wabakken T, Hauge H, Funderud S, Aasheim HC |title=Characterization, expression and functional aspects of a novel protein tyrosine phosphatase epsilon isoform. |journal=Scand. J. Immunol. |volume=56 |issue= 3 |pages= 276–85 |year= 2002 |pmid= 12193229 |doi=
*cite journal | author=Blanchetot C, Tertoolen LG, Overvoorde J, den Hertog J |title=Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47263–9 |year= 2003 |pmid= 12376545 |doi= 10.1074/jbc.M205810200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tiran Z, Peretz A, Attali B, Elson A |title=Phosphorylation-dependent regulation of Kv2.1 Channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase epsilon. |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 17509–14 |year= 2003 |pmid= 12615930 |doi= 10.1074/jbc.M212766200
*cite journal | author=Toledano-Katchalski H, Kraut J, Sines T, "et al." |title=Protein tyrosine phosphatase epsilon inhibits signaling by mitogen-activated protein kinases. |journal=Mol. Cancer Res. |volume=1 |issue= 7 |pages= 541–50 |year= 2004 |pmid= 12754301 |doi=

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