SRGN

Serglycin, also known as SRGN, is a human gene.cite web | title = Entrez Gene: SRGN serglycin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5552| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis.cite web | title = Entrez Gene: SRGN serglycin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5552| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schick BP |title=Regulation of expression of megakaryocyte and platelet proteoglycans. |journal=Stem Cells |volume=14 Suppl 1 |issue= |pages= 220–31 |year= 2000 |pmid= 11012225 |doi=
*cite journal | author=Humphries DE, Nicodemus CF, Schiller V, Stevens RL |title=The human serglycin gene. Nucleotide sequence and methylation pattern in human promyelocytic leukemia HL-60 cells and T-lymphoblast Molt-4 cells. |journal=J. Biol. Chem. |volume=267 |issue= 19 |pages= 13558–63 |year= 1992 |pmid= 1377686 |doi=
*cite journal | author=Nicodemus CF, Avraham S, Austen KF, "et al." |title=Characterization of the human gene that encodes the peptide core of secretory granule proteoglycans in promyelocytic leukemia HL-60 cells and analysis of the translated product. |journal=J. Biol. Chem. |volume=265 |issue= 10 |pages= 5889–96 |year= 1990 |pmid= 2180935 |doi=
*cite journal | author=Mattei MG, Périn JP, Alliel PM, "et al." |title=Localization of human platelet proteoglycan gene to chromosome 10, band q22.1, by in situ hybridization. |journal=Hum. Genet. |volume=82 |issue= 1 |pages= 87–8 |year= 1989 |pmid= 2714783 |doi=
*cite journal | author=Avraham S, Stevens RL, Nicodemus CF, "et al." |title=Molecular cloning of a cDNA that encodes the peptide core of a mouse mast cell secretory granule proteoglycan and comparison with the analogous rat and human cDNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 10 |pages= 3763–7 |year= 1989 |pmid= 2726751 |doi=
*cite journal | author=Stellrecht CM, Saunders GF |title=Nucleotide sequence of a cDNA encoding a hemopoietic proteoglycan core protein. |journal=Nucleic Acids Res. |volume=17 |issue= 18 |pages= 7523 |year= 1989 |pmid= 2798108 |doi=
*cite journal | author=Stevens RL, Avraham S, Gartner MC, "et al." |title=Isolation and characterization of a cDNA that encodes the peptide core of the secretory granule proteoglycan of human promyelocytic leukemia HL-60 cells. |journal=J. Biol. Chem. |volume=263 |issue= 15 |pages= 7287–91 |year= 1988 |pmid= 2835370 |doi=
*cite journal | author=Périn JP, Bonnet F, Maillet P, Jollès P |title=Characterization and N-terminal sequence of human platelet proteoglycan. |journal=Biochem. J. |volume=255 |issue= 3 |pages= 1007–13 |year= 1989 |pmid= 3214420 |doi=
*cite journal | author=Avraham S, Stevens RL, Gartner MC, "et al." |title=Isolation of a cDNA that encodes the peptide core of the secretory granule proteoglycan of rat basophilic leukemia-1 cells and assessment of its homology to the human analogue. |journal=J. Biol. Chem. |volume=263 |issue= 15 |pages= 7292–6 |year= 1988 |pmid= 3366780 |doi=
*cite journal | author=Alliel PM, Périn JP, Maillet P, "et al." |title=Complete amino acid sequence of a human platelet proteoglycan. |journal=FEBS Lett. |volume=236 |issue= 1 |pages= 123–6 |year= 1988 |pmid= 3402609 |doi=
*cite journal | author=Hatton MN, Loomis RE, Levine MJ, Tabak LA |title=Masticatory lubrication. The role of carbohydrate in the lubricating property of a salivary glycoprotein-albumin complex. |journal=Biochem. J. |volume=230 |issue= 3 |pages= 817–20 |year= 1985 |pmid= 4062880 |doi=
*cite journal | author=Schick BP, Jacoby JA |title=Serglycin and betaglycan proteoglycans are expressed in the megakaryocytic cell line CHRF 288-11 and normal human megakaryocytes. |journal=J. Cell. Physiol. |volume=165 |issue= 1 |pages= 96–106 |year= 1995 |pmid= 7559813 |doi= 10.1002/jcp.1041650113
*cite journal | author=Kato S, Sekine S, Oh SW, "et al." |title=Construction of a human full-length cDNA bank. |journal=Gene |volume=150 |issue= 2 |pages= 243–50 |year= 1995 |pmid= 7821789 |doi=
*cite journal | author=Kolset SO, Mann DM, Uhlin-Hansen L, "et al." |title=Serglycin-binding proteins in activated macrophages and platelets. |journal=J. Leukoc. Biol. |volume=59 |issue= 4 |pages= 545–54 |year= 1996 |pmid= 8613703 |doi=
*cite journal | author=Toyama-Sorimachi N, Kitamura F, Habuchi H, "et al." |title=Widespread expression of chondroitin sulfate-type serglycins with CD44 binding ability in hematopoietic cells. |journal=J. Biol. Chem. |volume=272 |issue= 42 |pages= 26714–9 |year= 1997 |pmid= 9334256 |doi=
*cite journal | author=Galvin JP, Spaeny-Dekking LH, Wang B, "et al." |title=Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo. |journal=J. Immunol. |volume=162 |issue= 9 |pages= 5345–50 |year= 1999 |pmid= 10228010 |doi=
*cite journal | author=Schick BP, Gradowski JF, San Antonio JD |title=Synthesis, secretion, and subcellular localization of serglycin proteoglycan in human endothelial cells. |journal=Blood |volume=97 |issue= 2 |pages= 449–58 |year= 2001 |pmid= 11154222 |doi=
*cite journal | author=Omtvedt LA, Kolset SO, Thoen J, "et al." |title=Serglycin expression in CD2+ and CD14+ cells from patients with various rheumatic diseases. |journal=Scand. J. Rheumatol. |volume=30 |issue= 3 |pages= 164–6 |year= 2001 |pmid= 11469527 |doi=
*cite journal | author=Metkar SS, Wang B, Aguilar-Santelises M, "et al." |title=Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. |journal=Immunity |volume=16 |issue= 3 |pages= 417–28 |year= 2002 |pmid= 11911826 |doi=

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