CDC25C

CDC25C

Cell division cycle 25 homolog C (S. pombe), also known as CDC25C, is a human gene.

PBB_Summary
section_title =
summary_text = This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.cite web | title = Entrez Gene: CDC25C cell division cycle 25 homolog C (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=995| accessdate = ]

ee also

* Cdc25

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Draetta G, Eckstein J |title=Cdc25 protein phosphatases in cell proliferation. |journal=Biochim. Biophys. Acta |volume=1332 |issue= 2 |pages= M53–63 |year= 1997 |pmid= 9141461 |doi=
*cite journal | author=Nilsson I, Hoffmann I |title=Cell cycle regulation by the Cdc25 phosphatase family. |journal=Progress in cell cycle research |volume=4 |issue= |pages= 107–14 |year= 2000 |pmid= 10740819 |doi=
*cite journal | author=Amini S, Khalili K, Sawaya BE |title=Effect of HIV-1 Vpr on cell cycle regulators. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 249–60 |year= 2004 |pmid= 15142382 |doi= 10.1089/104454904773819833
*cite journal | author=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue= |pages= 153–67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013
*cite journal | author=Andersen JL, Planelles V |title=The role of Vpr in HIV-1 pathogenesis. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 43–51 |year= 2005 |pmid= 15638722 |doi=10.2174/1570162052772988
*cite journal | author=Sartor H, Ehlert F, Grzeschik KH, "et al." |title=Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31 and 5q12, respectively. |journal=Genomics |volume=13 |issue= 3 |pages= 911–2 |year= 1992 |pmid= 1386342 |doi=10.1016/0888-7543(92)90190-4
*cite journal | author=Gould KL, Moreno S, Tonks NK, Nurse P |title=Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase. |journal=Science |volume=250 |issue= 4987 |pages= 1573–6 |year= 1991 |pmid= 1703321 |doi=10.1126/science.1703321
*cite journal | author=Strausfeld U, Labbé JC, Fesquet D, "et al." |title=Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein. |journal=Nature |volume=351 |issue= 6323 |pages= 242–5 |year= 1991 |pmid= 1828290 |doi= 10.1038/351242a0
*cite journal | author=Galaktionov K, Beach D |title=Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. |journal=Cell |volume=67 |issue= 6 |pages= 1181–94 |year= 1992 |pmid= 1836978 |doi=10.1016/0092-8674(91)90294-9
*cite journal | author=Sadhu K, Reed SI, Richardson H, Russell P |title=Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 13 |pages= 5139–43 |year= 1990 |pmid= 2195549 |doi=10.1073/pnas.87.13.5139
*cite journal | author=Re F, Braaten D, Franke EK, Luban J |title=Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B. |journal=J. Virol. |volume=69 |issue= 11 |pages= 6859–64 |year= 1995 |pmid= 7474100 |doi=
*cite journal | author=Zwicker J, Gross C, Lucibello FC, "et al." |title=Cell cycle regulation of cdc25C transcription is mediated by the periodic repression of the glutamine-rich activators NF-Y and Sp1. |journal=Nucleic Acids Res. |volume=23 |issue= 19 |pages= 3822–30 |year= 1995 |pmid= 7479023 |doi=10.1093/nar/23.19.3822
*cite journal | author=Di Marzio P, Choe S, Ebright M, "et al." |title=Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr. |journal=J. Virol. |volume=69 |issue= 12 |pages= 7909–16 |year= 1996 |pmid= 7494303 |doi=
*cite journal | author=Strausfeld U, Fernandez A, Capony JP, "et al." |title=Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis. |journal=J. Biol. Chem. |volume=269 |issue= 8 |pages= 5989–6000 |year= 1994 |pmid= 8119945 |doi=
*cite journal | author=Zheng XF, Ruderman JV |title=Functional analysis of the P box, a domain in cyclin B required for the activation of Cdc25. |journal=Cell |volume=75 |issue= 1 |pages= 155–64 |year= 1993 |pmid= 8402895 |doi=
*cite journal | author=Taviaux SA, Demaille JG |title=Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization. |journal=Genomics |volume=15 |issue= 1 |pages= 194–6 |year= 1993 |pmid= 8432534 |doi= 10.1006/geno.1993.1032
*cite journal | author=Honda R, Ohba Y, Nagata A, "et al." |title=Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase. |journal=FEBS Lett. |volume=318 |issue= 3 |pages= 331–4 |year= 1993 |pmid= 8440392 |doi=10.1016/0014-5793(93)80540-B
*cite journal | author=Booher RN, Holman PS, Fattaey A |title=Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. |journal=J. Biol. Chem. |volume=272 |issue= 35 |pages= 22300–6 |year= 1997 |pmid= 9268380 |doi=10.1074/jbc.272.35.22300
*cite journal | author=Sanchez Y, Wong C, Thoma RS, "et al." |title=Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. |journal=Science |volume=277 |issue= 5331 |pages= 1497–501 |year= 1997 |pmid= 9278511 |doi=10.1126/science.277.5331.1497

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