- PTK2B
PTK2B protein tyrosine kinase 2 beta, also known as PTK2B, is a human
gene .Protein
PBB_Summary
section_title =
summary_text = This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [cite web | title = Entrez Gene: PTK2B PTK2B protein tyrosine kinase 2 beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2185| accessdate = ]ee also
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Tyrosine kinase References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Avraham S, Avraham H |title=Characterization of the novel focal adhesion kinase RAFTK in hematopoietic cells. |journal=Leuk. Lymphoma |volume=27 |issue= 3-4 |pages= 247–56 |year= 1998 |pmid= 9402324 |doi=
*cite journal | author=Schlaepfer DD, Hauck CR, Sieg DJ |title=Signaling through focal adhesion kinase. |journal=Prog. Biophys. Mol. Biol. |volume=71 |issue= 3-4 |pages= 435–78 |year= 1999 |pmid= 10354709 |doi=
*cite journal | author=Loeser RF |title=Integrins and cell signaling in chondrocytes. |journal=Biorheology |volume=39 |issue= 1-2 |pages= 119–24 |year= 2002 |pmid= 12082274 |doi=PBB_Controls
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