PTPN12

Protein tyrosine phosphatase, non-receptor type 12, also known as PTPN12, is a human gene.cite web | title = Entrez Gene: PTPN12 protein tyrosine phosphatase, non-receptor type 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5782| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. This PTP was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility.cite web | title = Entrez Gene: PTPN12 protein tyrosine phosphatase, non-receptor type 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5782| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Takekawa M, Itoh F, Hinoda Y, "et al." |title=Cloning and characterization of a human cDNA encoding a novel putative cytoplasmic protein-tyrosine-phosphatase. |journal=Biochem. Biophys. Res. Commun. |volume=189 |issue= 2 |pages= 1223–30 |year= 1993 |pmid= 1472029 |doi=
*cite journal | author=Yi T, Cleveland JL, Ihle JN |title=Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. |journal=Blood |volume=78 |issue= 9 |pages= 2222–8 |year= 1991 |pmid= 1932742 |doi=
*cite journal | author=Takekawa M, Itoh F, Hinoda Y, "et al." |title=Chromosomal localization of the protein tyrosine phosphatase G1 gene and characterization of the aberrant transcripts in human colon cancer cells. |journal=FEBS Lett. |volume=339 |issue= 3 |pages= 222–8 |year= 1994 |pmid= 7509295 |doi=
*cite journal | author=Garton AJ, Tonks NK |title=PTP-PEST: a protein tyrosine phosphatase regulated by serine phosphorylation. |journal=EMBO J. |volume=13 |issue= 16 |pages= 3763–71 |year= 1994 |pmid= 7520867 |doi=
*cite journal | author=Habib T, Herrera R, Decker SJ |title=Activators of protein kinase C stimulate association of Shc and the PEST tyrosine phosphatase. |journal=J. Biol. Chem. |volume=269 |issue= 41 |pages= 25243–6 |year= 1994 |pmid= 7929214 |doi=
*cite journal | author=Yang Q, Co D, Sommercorn J, Tonks NK |title=Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase. |journal=J. Biol. Chem. |volume=268 |issue= 23 |pages= 17650 |year= 1993 |pmid= 8349645 |doi=
*cite journal | author=Yang Q, Co D, Sommercorn J, Tonks NK |title=Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase. |journal=J. Biol. Chem. |volume=268 |issue= 9 |pages= 6622–8 |year= 1993 |pmid= 8454633 |doi=
*cite journal | author=Charest A, Wagner J, Jacob S, "et al." |title=Phosphotyrosine-independent binding of SHC to the NPLH sequence of murine protein-tyrosine phosphatase-PEST. Evidence for extended phosphotyrosine binding/phosphotyrosine interaction domain recognition specificity. |journal=J. Biol. Chem. |volume=271 |issue= 14 |pages= 8424–9 |year= 1996 |pmid= 8626541 |doi=
*cite journal | author=Garton AJ, Flint AJ, Tonks NK |title=Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST. |journal=Mol. Cell. Biol. |volume=16 |issue= 11 |pages= 6408–18 |year= 1996 |pmid= 8887669 |doi=
*cite journal | author=Charest A, Wagner J, Kwan M, Tremblay ML |title=Coupling of the murine protein tyrosine phosphatase PEST to the epidermal growth factor (EGF) receptor through a Src homology 3 (SH3) domain-mediated association with Grb2. |journal=Oncogene |volume=14 |issue= 14 |pages= 1643–51 |year= 1997 |pmid= 9135065 |doi= 10.1038/sj.onc.1201008
*cite journal | author=Garton AJ, Burnham MR, Bouton AH, Tonks NK |title=Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition. |journal=Oncogene |volume=15 |issue= 8 |pages= 877–85 |year= 1997 |pmid= 9285683 |doi= 10.1038/sj.onc.1201279
*cite journal | author=Dowbenko D, Spencer S, Quan C, Lasky LA |title=Identification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting protein. |journal=J. Biol. Chem. |volume=273 |issue= 2 |pages= 989–96 |year= 1998 |pmid= 9422760 |doi=
*cite journal | author=Shen Y, Schneider G, Cloutier JF, "et al." |title=Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin. |journal=J. Biol. Chem. |volume=273 |issue= 11 |pages= 6474–81 |year= 1998 |pmid= 9497381 |doi=
*cite journal | author=Côté JF, Charest A, Wagner J, Tremblay ML |title=Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as a model. |journal=Biochemistry |volume=37 |issue= 38 |pages= 13128–37 |year= 1998 |pmid= 9748319 |doi= 10.1021/bi981259l
*cite journal | author=Wu Y, Dowbenko D, Lasky LA |title=PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase. |journal=J. Biol. Chem. |volume=273 |issue= 46 |pages= 30487–96 |year= 1998 |pmid= 9804817 |doi=
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Li J, Nishizawa K, An W, "et al." |title=A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion. |journal=EMBO J. |volume=17 |issue= 24 |pages= 7320–36 |year= 1999 |pmid= 9857189 |doi= 10.1093/emboj/17.24.7320
*cite journal | author=Garton AJ, Tonks NK |title=Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST. |journal=J. Biol. Chem. |volume=274 |issue= 6 |pages= 3811–8 |year= 1999 |pmid= 9920935 |doi=
*cite journal | author=Angers-Loustau A, Côté JF, Charest A, "et al." |title=Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts. |journal=J. Cell Biol. |volume=144 |issue= 5 |pages= 1019–31 |year= 1999 |pmid= 10085298 |doi=
*cite journal | author=Nishiya N, Iwabuchi Y, Shibanuma M, "et al." |title=Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain. |journal=J. Biol. Chem. |volume=274 |issue= 14 |pages= 9847–53 |year= 1999 |pmid= 10092676 |doi=

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