DLG3

Discs, large homolog 3 (Drosophila)
PDB rendering based on 1um7.
Available structures PDB 1UM7, 2FE5, 2I1N
Identifiers
Symbols	DLG3; KIAA1232; MRX; MRX90; NEDLG; SAP102; XLMR
External IDs	OMIM: 300189 MGI: 1888986 HomoloGene: 41157 GeneCards: DLG3 Gene
Gene Ontology Molecular function • guanylate kinase activity • protein binding • protein C-terminus binding • PDZ domain binding • ionotropic glutamate receptor binding Cellular component • plasma membrane • plasma membrane • growth cone • neuronal cell body • dendritic shaft • synapse Biological process • synaptic transmission • axon guidance • negative regulation of cell proliferation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1741	53310
Ensembl	ENSG00000082458	ENSMUSG00000000881
UniProt	Q92796	Q80TH1
RefSeq (mRNA)	NM_001166278.1	NM_016747
RefSeq (protein)	NP_001159750.1	NP_058027
Location (UCSC)	Chr X: 69.66 – 69.73 Mb	Chr X: 97.96 – 98.01 Mb
PubMed search	[1]	[2]

Disks large homolog 3 (DLG3) also known as neuroendocrine-DLG or synapse-associated protein 102 (SAP-102) is a protein that in humans is encoded by the DLG3 gene.^[1][2] DLG3 is a member of the membrane-associated guanylate kinase (MAGUK) superfamily of proteins.

Interactions

DLG3 has been shown to interact with GRIN2C,^[3] PTK2B,^[4] GRIN2A,^[5][3] GRIN2B,^[6][7][5][3] SYNGAP1,^[8] CRIPT,^[3] DLG4,^[9] EXOC4,^[6] APC,^[10] KCNJ12^[11] and EXOC3.^[6]

References

1. ^ Stathakis DG, Lee D, Bryant PJ (Aug 1998). "DLG3, the gene encoding human neuroendocrine Dlg (NE-Dlg), is located within the 1.8-Mb dystonia-parkinsonism region at Xq13.1". Genomics 49 (2): 310–3. doi:10.1006/geno.1998.5243. PMID 9598320. 
2. ^ "Entrez Gene: DLG3 Discs, large homolog 3 (neuroendocrine-dlg, Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1741. 
3. ^ ^{a b c d} Lim, Indra Adi; Hall Duane D, Hell Johannes W (Jun. 2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". J. Biol. Chem. (United States) 277 (24): 21697–711. doi:10.1074/jbc.M112339200. ISSN 0021-9258. PMID 11937501. 
4. ^ Seabold, Gail K; Burette Alain, Lim Indra A, Weinberg Richard J, Hell Johannes W (Apr. 2003). "Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102". J. Biol. Chem. (United States) 278 (17): 15040–8. doi:10.1074/jbc.M212825200. ISSN 0021-9258. PMID 12576483. 
5. ^ ^{a b} Irie, M; Hata Y, Takeuchi M, Ichtchenko K, Toyoda A, Hirao K, Takai Y, Rosahl T W, Südhof T C (Sep. 1997). "Binding of neuroligins to PSD-95". Science (UNITED STATES) 277 (5331): 1511–5. doi:10.1126/science.277.5331.1511. ISSN 0036-8075. PMID 9278515. 
6. ^ ^{a b c} Sans, Nathalie; Prybylowski Kate, Petralia Ronald S, Chang Kai, Wang Ya-Xian, Racca Claudia, Vicini Stefano, Wenthold Robert J (Jun. 2003). "NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex". Nat. Cell Biol. (England) 5 (6): 520–30. doi:10.1038/ncb990. ISSN 1465-7392. PMID 12738960. 
7. ^ Inanobe, Atsushi; Fujita Akikazu, Ito Minoru, Tomoike Hitonobu, Inageda Kiyoshi, Kurachi Yoshihisa (Jun. 2002). "Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses". Am. J. Physiol., Cell Physiol. (United States) 282 (6): C1396–403. doi:10.1152/ajpcell.00615.2001. ISSN 0363-6143. PMID 11997254. 
8. ^ Kim, J H; Liao D, Lau L F, Huganir R L (Apr. 1998). "SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family". Neuron (UNITED STATES) 20 (4): 683–91. doi:10.1016/S0896-6273(00)81008-9. ISSN 0896-6273. PMID 9581761. 
9. ^ Masuko, N; Makino K, Kuwahara H, Fukunaga K, Sudo T, Araki N, Yamamoto H, Yamada Y, Miyamoto E, Saya H (Feb. 1999). "Interaction of NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane-associated guanylate kinase protein, with calmodulin and PSD-95/SAP90. A possible regulatory role in molecular clustering at synaptic sites". J. Biol. Chem. (UNITED STATES) 274 (9): 5782–90. doi:10.1074/jbc.274.9.5782. ISSN 0021-9258. PMID 10026200. 
10. ^ Makino, K; Kuwahara H, Masuko N, Nishiyama Y, Morisaki T, Sasaki J, Nakao M, Kuwano A, Nakata M, Ushio Y, Saya H (May. 1997). "Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein". Oncogene (ENGLAND) 14 (20): 2425–33. doi:10.1038/sj.onc.1201087. ISSN 0950-9232. PMID 9188857. 
11. ^ Leonoudakis, Dmitri; Conti Lisa R, Anderson Scott, Radeke Carolyn M, McGuire Leah M M, Adams Marvin E, Froehner Stanley C, Yates John R, Vandenberg Carol A (May. 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. (United States) 279 (21): 22331–46. doi:10.1074/jbc.M400285200. ISSN 0021-9258. PMID 15024025. 

Further reading

• Lau LF, Mammen A, Ehlers MD, et al. (1996). "Interaction of the N-methyl-D-aspartate receptor complex with a novel synapse-associated protein, SAP102.". J. Biol. Chem. 271 (35): 21622–8. doi:10.1074/jbc.271.35.21622. PMID 8702950. 
• Müller BM, Kistner U, Kindler S, et al. (1996). "SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo.". Neuron 17 (2): 255–65. doi:10.1016/S0896-6273(00)80157-9. PMID 8780649. 
• Takeuchi M, Hata Y, Hirao K, et al. (1997). "SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density.". J. Biol. Chem. 272 (18): 11943–51. doi:10.1074/jbc.272.18.11943. PMID 9115257. 
• Makino K, Kuwahara H, Masuko N, et al. (1997). "Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein.". Oncogene 14 (20): 2425–33. doi:10.1038/sj.onc.1201087. PMID 9188857. 
• Irie M, Hata Y, Takeuchi M, et al. (1997). "Binding of neuroligins to PSD-95.". Science 277 (5331): 1511–5. doi:10.1126/science.277.5331.1511. PMID 9278515. 
• Kim JH, Liao D, Lau LF, Huganir RL (1998). "SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family.". Neuron 20 (4): 683–91. doi:10.1016/S0896-6273(00)81008-9. PMID 9581761. 
• Butz S, Okamoto M, Südhof TC (1998). "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.". Cell 94 (6): 773–82. doi:10.1016/S0092-8674(00)81736-5. PMID 9753324. 
• Garcia EP, Mehta S, Blair LA, et al. (1998). "SAP90 binds and clusters kainate receptors causing incomplete desensitization.". Neuron 21 (4): 727–39. doi:10.1016/S0896-6273(00)80590-5. PMID 9808460. 
• Masuko N, Makino K, Kuwahara H, et al. (1999). "Interaction of NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane-associated guanylate kinase protein, with calmodulin and PSD-95/SAP90. A possible regulatory role in molecular clustering at synaptic sites.". J. Biol. Chem. 274 (9): 5782–90. doi:10.1074/jbc.274.9.5782. PMID 10026200. 
• Kuwahara H, Araki N, Makino K, et al. (1999). "A novel NE-dlg/SAP102-associated protein, p51-nedasin, related to the amidohydrolase superfamily, interferes with the association between NE-dlg/SAP102 and N-methyl-D-aspartate receptor.". J. Biol. Chem. 274 (45): 32204–14. doi:10.1074/jbc.274.45.32204. PMID 10542258. 
• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462. 
• Firestein BL, Firestein BL, Brenman JE, et al. (2000). "Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting.". Neuron 24 (3): 659–72. doi:10.1016/S0896-6273(00)81120-4. PMID 10595517. 
• Garcia RA, Vasudevan K, Buonanno A (2000). "The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3596–601. doi:10.1073/pnas.070042497. PMC 16285. PMID 10725395. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16285. 
• Husi H, Ward MA, Choudhary JS, et al. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.". Nat. Neurosci. 3 (7): 661–9. doi:10.1038/76615. PMID 10862698. 
• Inagaki S, Ohoka Y, Sugimoto H, et al. (2001). "Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95.". J. Biol. Chem. 276 (12): 9174–81. doi:10.1074/jbc.M009051200. PMID 11134026. 
• DeMarco SJ, Strehler EE (2001). "Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins.". J. Biol. Chem. 276 (24): 21594–600. doi:10.1074/jbc.M101448200. PMID 11274188. 
• Russwurm M, Wittau N, Koesling D (2002). "Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes.". J. Biol. Chem. 276 (48): 44647–52. doi:10.1074/jbc.M105587200. PMID 11572861. 
• Lim IA, Hall DD, Hell JW (2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102.". J. Biol. Chem. 277 (24): 21697–711. doi:10.1074/jbc.M112339200. PMID 11937501. 
• Cai C, Coleman SK, Niemi K, Keinänen K (2002). "Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif.". J. Biol. Chem. 277 (35): 31484–90. doi:10.1074/jbc.M204354200. PMID 12070168.