GRIN2C

Glutamate receptor, ionotropic, N-methyl D-aspartate 2C, also known as GRIN2C, is a human gene.cite web | title = Entrez Gene: GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2905| accessdate = ]

PBB_Summary
section_title =
summary_text = N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).cite web | title = Entrez Gene: GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2905| accessdate = ]

ee also

* Glutamate receptor
* NMDA receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schröder HC, Perovic S, Kavsan V, "et al." |title=Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. |journal=Neurotoxicology |volume=19 |issue= 4-5 |pages= 683–8 |year= 1998 |pmid= 9745929 |doi=
*cite journal | author=King JE, Eugenin EA, Buckner CM, Berman JW |title=HIV tat and neurotoxicity. |journal=Microbes Infect. |volume=8 |issue= 5 |pages= 1347–57 |year= 2006 |pmid= 16697675 |doi= 10.1016/j.micinf.2005.11.014
*cite journal | author=Monyer H, Sprengel R, Schoepfer R, "et al." |title=Heteromeric NMDA receptors: molecular and functional distinction of subtypes. |journal=Science |volume=256 |issue= 5060 |pages= 1217–21 |year= 1992 |pmid= 1350383 |doi=
*cite journal | author=Kornau HC, Schenker LT, Kennedy MB, Seeburg PH |title=Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. |journal=Science |volume=269 |issue= 5231 |pages= 1737–40 |year= 1995 |pmid= 7569905 |doi=
*cite journal | author=Magnuson DS, Knudsen BE, Geiger JD, "et al." |title=Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity. |journal=Ann. Neurol. |volume=37 |issue= 3 |pages= 373–80 |year= 1995 |pmid= 7695237 |doi= 10.1002/ana.410370314
*cite journal | author=Takano H, Onodera O, Tanaka H, "et al." |title=Chromosomal localization of the epsilon 1, epsilon 3 and zeta 1 subunit genes of the human NMDA receptor channel. |journal=Biochem. Biophys. Res. Commun. |volume=197 |issue= 2 |pages= 922–6 |year= 1994 |pmid= 8267632 |doi=
*cite journal | author=Lannuzel A, Lledo PM, Lamghitnia HO, "et al." |title=HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+] i increase, alter [Ca2+] i homeostasis and induce neurotoxicity in human embryonic neurons. |journal=Eur. J. Neurosci. |volume=7 |issue= 11 |pages= 2285–93 |year= 1996 |pmid= 8563977 |doi=
*cite journal | author=Corasaniti MT, Melino G, Navarra M, "et al." |title=Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase. |journal=Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration |volume=4 |issue= 3 |pages= 315–21 |year= 1996 |pmid= 8581564 |doi=
*cite journal | author=Pittaluga A, Pattarini R, Severi P, Raiteri M |title=Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120. |journal=AIDS |volume=10 |issue= 5 |pages= 463–8 |year= 1996 |pmid= 8724036 |doi=
*cite journal | author=Wu P, Price P, Du B, "et al." |title=Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons. |journal=Neuroreport |volume=7 |issue= 5 |pages= 1045–9 |year= 1996 |pmid= 8804048 |doi=
*cite journal | author=Bennett BA, Rusyniak DE, Hollingsworth CK |title=HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures. |journal=Brain Res. |volume=705 |issue= 1-2 |pages= 168–76 |year= 1996 |pmid= 8821747 |doi=
*cite journal | author=Toggas SM, Masliah E, Mucke L |title=Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine. |journal=Brain Res. |volume=706 |issue= 2 |pages= 303–7 |year= 1996 |pmid= 8822372 |doi=
*cite journal | author=Dreyer EB, Lipton SA |title=The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid. |journal=Eur. J. Neurosci. |volume=7 |issue= 12 |pages= 2502–7 |year= 1996 |pmid= 8845955 |doi=
*cite journal | author=Raber J, Toggas SM, Lee S, "et al." |title=Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase. |journal=Virology |volume=226 |issue= 2 |pages= 362–73 |year= 1997 |pmid= 8955056 |doi= 10.1006/viro.1996.0664
*cite journal | author=Lin YJ, Bovetto S, Carver JM, Giordano T |title=Cloning of the cDNA for the human NMDA receptor NR2C subunit and its expression in the central nervous system and periphery. |journal=Brain Res. Mol. Brain Res. |volume=43 |issue= 1-2 |pages= 57–64 |year= 1997 |pmid= 9037519 |doi=
*cite journal | author=Kalsi G, Whiting P, Bourdelles BL, "et al." |title=Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels. |journal=Genomics |volume=47 |issue= 3 |pages= 423–5 |year= 1998 |pmid= 9480759 |doi= 10.1006/geno.1997.5132
*cite journal | author=Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ |title=CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. |journal=Mol. Cell. Neurosci. |volume=11 |issue= 3 |pages= 161–72 |year= 1998 |pmid= 9647694 |doi= 10.1006/mcne.1998.0679
*cite journal | author=New DR, Maggirwar SB, Epstein LG, "et al." |title=HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism. |journal=J. Biol. Chem. |volume=273 |issue= 28 |pages= 17852–8 |year= 1998 |pmid= 9651389 |doi=
*cite journal | author=Daggett LP, Johnson EC, Varney MA, "et al." |title=The human N-methyl-D-aspartate receptor 2C subunit: genomic analysis, distribution in human brain, and functional expression. |journal=J. Neurochem. |volume=71 |issue= 5 |pages= 1953–68 |year= 1998 |pmid= 9798920 |doi=

External links

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