GSTT2

Glutathione S-transferase theta 2, also known as GSTT2, is a human gene.cite web | title = Entrez Gene: GSTT2 glutathione S-transferase theta 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2953| accessdate = ]

PBB_Summary
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summary_text = Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar structure, being composed of five exons with identical exon/intron boundaries.cite web | title = Entrez Gene: GSTT2 glutathione S-transferase theta 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2953| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hussey AJ, Hayes JD |title=Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate. |journal=Biochem. J. |volume=286 ( Pt 3) |issue= |pages= 929–35 |year= 1992 |pmid= 1417752 |doi=
*cite journal | author=Tan KL, Webb GC, Baker RT, Board PG |title=Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22. |journal=Genomics |volume=25 |issue= 2 |pages= 381–7 |year= 1995 |pmid= 7789971 |doi=
*cite journal | author=Whittington AT, Webb GC, Baker RT, Board PG |title=Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1. |journal=Genomics |volume=33 |issue= 1 |pages= 105–11 |year= 1996 |pmid= 8617493 |doi= 10.1006/geno.1996.0165
*cite journal | author=Webb G, Vaska V, Coggan M, Board P |title=Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1). |journal=Genomics |volume=33 |issue= 1 |pages= 121–3 |year= 1996 |pmid= 8617495 |doi= 10.1006/geno.1996.0167
*cite journal | author=Mainwaring GW, Williams SM, Foster JR, "et al." |title=The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human. |journal=Biochem. J. |volume=318 ( Pt 1) |issue= |pages= 297–303 |year= 1996 |pmid= 8761485 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Chelvanayagam G, Wilce MC, Parker MW, "et al." |title=Homology model for the human GSTT2 Theta class glutathione transferase. |journal=Proteins |volume=27 |issue= 1 |pages= 118–30 |year= 1997 |pmid= 9037717 |doi=
*cite journal | author=Rossjohn J, McKinstry WJ, Oakley AJ, "et al." |title=Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site. |journal=Structure |volume=6 |issue= 3 |pages= 309–22 |year= 1998 |pmid= 9551553 |doi=
*cite journal | author=Coggan M, Whitbread L, Whittington A, Board P |title=Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex. |journal=Biochem. J. |volume=334 ( Pt 3) |issue= |pages= 617–23 |year= 1998 |pmid= 9729470 |doi=
*cite journal | author=de Bruin WC, Wagenmans MJ, Board PG, Peters WH |title=Expression of glutathione S-transferase theta class isoenzymes in human colorectal and gastric cancers. |journal=Carcinogenesis |volume=20 |issue= 8 |pages= 1453–7 |year= 1999 |pmid= 10426791 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=de Bruin WC, Wagenmans MJ, Peters WH |title=Expression of glutathione S-transferase alpha, P1-1 and T1-1 in the human gastrointestinal tract. |journal=Jpn. J. Cancer Res. |volume=91 |issue= 3 |pages= 310–6 |year= 2000 |pmid= 10760690 |doi=
*cite journal | author=Sprenger R, Schlagenhaufer R, Kerb R, "et al." |title=Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation. |journal=Pharmacogenetics |volume=10 |issue= 6 |pages= 557–65 |year= 2001 |pmid= 10975610 |doi=
*cite journal | author=Venter JC, Adams MD, Myers EW, "et al." |title=The sequence of the human genome. |journal=Science |volume=291 |issue= 5507 |pages= 1304–51 |year= 2001 |pmid= 11181995 |doi= 10.1126/science.1058040
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=De Maria F, Pedersen JZ, Caccuri AM, "et al." |title=The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide. |journal=J. Biol. Chem. |volume=278 |issue= 43 |pages= 42283–93 |year= 2004 |pmid= 12871945 |doi= 10.1074/jbc.M305568200
*cite journal | author=Collins JE, Wright CL, Edwards CA, "et al." |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Jang SG, Kim IJ, Kang HC, "et al." |title=GSTT2 promoter polymorphisms and colorectal cancer risk. |journal=BMC Cancer |volume=7 |issue= |pages= 16 |year= 2007 |pmid= 17250773 |doi= 10.1186/1471-2407-7-16

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