GNG2

GNG2

Guanine nucleotide binding protein (G protein), gamma 2, also known as GNG2, is a human gene.cite web | title = Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54331| accessdate = ]

PBB_Summary
section_title =
summary_text = Heterotrimeric G proteins play vital roles in cellular responses to external signals. The specificity of a G protein-receptor interaction is primarily mediated by the gamma subunit. [supplied by OMIM] cite web | title = Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54331| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Pumiglia KM, LeVine H, Haske T, "et al." |title=A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase. |journal=J. Biol. Chem. |volume=270 |issue= 24 |pages= 14251–4 |year= 1995 |pmid= 7782277 |doi=
*cite journal | author=Tsukada S, Simon MI, Witte ON, Katz A |title=Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 23 |pages= 11256–60 |year= 1994 |pmid= 7972043 |doi=
*cite journal | author=Yan K, Kalyanaraman V, Gautam N |title=Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 7141–6 |year= 1996 |pmid= 8636150 |doi=
*cite journal | author=De Waard M, Liu H, Walker D, "et al." |title=Direct binding of G-protein betagamma complex to voltage-dependent calcium channels. |journal=Nature |volume=385 |issue= 6615 |pages= 446–50 |year= 1997 |pmid= 9009193 |doi= 10.1038/385446a0
*cite journal | author=Kostenis E, Conklin BR, Wess J |title=Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits. |journal=Biochemistry |volume=36 |issue= 6 |pages= 1487–95 |year= 1997 |pmid= 9063897 |doi= 10.1021/bi962554d
*cite journal | author=Qin N, Platano D, Olcese R, "et al." |title=Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 16 |pages= 8866–71 |year= 1997 |pmid= 9238069 |doi=
*cite journal | author=Ong OC, Hu K, Rong H, "et al." |title=Gene structure and chromosome localization of the G gamma c subunit of human cone G-protein (GNGT2). |journal=Genomics |volume=44 |issue= 1 |pages= 101–9 |year= 1997 |pmid= 9286705 |doi= 10.1006/geno.1997.4814
*cite journal | author=Nishida K, Kaziro Y, Satoh T |title=Association of the proto-oncogene product dbl with G protein betagamma subunits. |journal=FEBS Lett. |volume=459 |issue= 2 |pages= 186–90 |year= 1999 |pmid= 10518015 |doi=
*cite journal | author=Carman CV, Barak LS, Chen C, "et al." |title=Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10443–52 |year= 2000 |pmid= 10744734 |doi=
*cite journal | author=Modarressi MH, Taylor KE, Wolfe J |title=Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit. |journal=Biochem. Biophys. Res. Commun. |volume=272 |issue= 2 |pages= 610–5 |year= 2000 |pmid= 10833460 |doi= 10.1006/bbrc.2000.2832
*cite journal | author=Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB |title=Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23945–53 |year= 2001 |pmid= 11294873 |doi= 10.1074/jbc.M101154200
*cite journal | author=Yu Y, Zhang C, Zhou G, "et al." |title=Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 8 |pages= 1392–403 |year= 2001 |pmid= 11483580 |doi= 10.1101/gr.175501
*cite journal | author=Lowry WE, Huang XY |title=G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase. |journal=J. Biol. Chem. |volume=277 |issue= 2 |pages= 1488–92 |year= 2002 |pmid= 11698416 |doi= 10.1074/jbc.M110390200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Cuello F, Schulze RA, Heemeyer F, "et al." |title=Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7220–6 |year= 2003 |pmid= 12486123 |doi= 10.1074/jbc.M210304200
*cite journal | author=Melliti K, Grabner M, Seabrook GR |title=The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cells. |journal=J. Physiol. (Lond.) |volume=546 |issue= Pt 2 |pages= 337–47 |year= 2003 |pmid= 12527722 |doi=
*cite journal | author=Wolfe JT, Wang H, Howard J, "et al." |title=T-type calcium channel regulation by specific G-protein betagamma subunits. |journal=Nature |volume=424 |issue= 6945 |pages= 209–13 |year= 2003 |pmid= 12853961 |doi= 10.1038/nature01772
*cite journal | author=Niu J, Profirovic J, Pan H, "et al." |title=G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production. |journal=Circ. Res. |volume=93 |issue= 9 |pages= 848–56 |year= 2003 |pmid= 14512443 |doi= 10.1161/01.RES.0000097607.14733.0C
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Doering CJ, Kisilevsky AE, Feng ZP, "et al." |title=A single Gbeta subunit locus controls cross-talk between protein kinase C and G protein regulation of N-type calcium channels. |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 29709–17 |year= 2004 |pmid= 15105422 |doi= 10.1074/jbc.M308693200

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