- Non-receptor tyrosine kinase
-
non-membrane spanning protein tyrosine kinase Identifiers EC number 2.7.10.2 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles Non-receptor tyrosine kinases or non-specific protein-tyrosine kinases are enzymes that can transfer a phosphate group from ATP to a tyrosine residue in a protein. Non-receptor tyrosine kinases are a subgroup of the larger class of tyrosine kinases. Phosphorylation of proteins by kinases is an important mechanism in signal transduction for regulation of enzyme activity.
Structural studies
As of late 2007, 37 structures have been solved for this class of enzymes, with PDB accession codes 2DM0, 2DQ7, 2E2B, 2E6I, 2EKX, 2GQG, 2H8H, 2HDA, 2HIW, 2HK5, 2HWO, 2HWP, 2HYY, 2HZ0, 2HZ4, 2HZI, 2HZN, 2IJM, 2IN6, 2IO6, 2J0J, 2J0K, 2J0L, 2J0M, 2O88, 2OF2, 2OF4, 2OFU, 2OFV, 2OG8, 2OI3, 2OIQ, 2OQ1, 2OZO, 2QOH, 2V7A, and 2Z60.
References
- Robinson DR, Wu YM, Lin SF (2000). "The protein tyrosine kinase family of the human genome". Oncogene. 19 (49): 5548–57. doi:10.1038/sj.onc.1203957. PMID 11114734.
- Roskoski R Jr (2004). "Src protein-tyrosine kinase structure and regulation". Biochem. Biophys. Res. Commun. 324 (4): 1155–64. doi:10.1016/j.bbrc.2004.09.171. PMID 15504335.
EPH receptor familyLTK receptor familyLTK · ALKTIE receptor familyROR receptor familyROR1 · ROR2DDR receptor familyPTK7 receptor familyRYK receptor familyMuSK receptor familyROS receptor familyAATYK receptor familyAXL receptor familyRET receptor familyuncatagorisedNon-receptor tyrosine kinases (EC 2.7.10.2) ABL familyACK familyACK1 · TNK1CSK familyFAK familyFES familyFRK familyJAK familySRC-A familySRC-B familyTEC familySYK familyB enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6 MAP see MAP kinase pathwayCalcium Intracellular calcium-sensing proteins • Calcineurin • Calcium-calmodulin-dependent protein kinaseG protein cAMP: Heterotrimeric G protein (Gs/Gi) • Adenylate cyclase • cAMP • 3',5'-cyclic-AMP phosphodiesterase • Protein kinase A
cGMP: Guanylate cyclase • cGMP • 3',5'-cyclic-GMP phosphodiesterase • Protein kinase G
Beta-gamma complex Gβ (GNB1, GNB2, GNB3, GNB4, GNB5) • Gγ (GNGT1, GNGT2, GNG2, GNG3, GNG4, GNG5, GNG7, GNG8, GNG10, GNG11, GNG12, GNG13, BSCL2)
G protein-coupled receptor kinase • AMP-activated protein kinaseCyclin Lipid Phosphoinositide phospholipase C • Phospholipase c gammaOther protein kinase Serine/threonine: Casein kinase (1, 2) • eIF-2 kinase (EIF2AK3) • Glycogen synthase kinase (GSK1, GSK2, GSK-3, GSK3A, GSK3B) • IκB kinase (CHUK, IKK2, IKBKG) • Interleukin-1 receptor-associated kinase (IRAK1, IRAK2, IRAK3, IRAK4) • Lim kinase (LIMK1, LIMK2) • p21 activated kinases (PAK1, PAK2, PAK3, PAK4) • Rho-associated protein kinase (ROCK1, ROCK2) • Ribosomal s6 kinase (RPS6KA1)
Tyrosine: ZAP70 • Focal adhesion protein-tyrosine kinase (PTK2, PTK2B) • BTK
both: Dual-specificity kinaseOther phosphoprotein phosphatase Serine/threonine: Protein phosphatase 2
Tyrosine: protein tyrosine phosphatase: Receptor-like protein tyrosine phosphatase • Sh2 domain-containing protein tyrosine phosphatase
both: Dual-specificity phosphataseApoptosis see apoptosis signaling pathwayGTP-binding protein regulators Other Activating transcription factor 6 • Signal transducing adaptor protein • I-kappa B protein • Mucin-4 • Olfactory marker protein • Phosphatidylethanolamine binding protein • EDARADD • PRKCSHsee also deficiencies of intracellular signaling peptides and proteins
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)Categories:- Enzyme stubs
- EC 2.7.10
- Enzymes of known structure
Wikimedia Foundation. 2010.
