EPH receptor A2

EPH receptor A2

EPH receptor A2, also known as EPHA2, is a human gene. [cite web | title = Entrez Gene: EPHA2 EPH receptor A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1969| accessdate = ]

section_title =
summary_text = This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands.cite web | title = Entrez Gene: EPHA2 EPH receptor A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1969| accessdate = ]


citations =
*cite journal | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue= |pages= 309–45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309
*cite journal | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151–81 |year= 1998 |pmid= 9576626 |doi=
*cite journal | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033–44 |year= 1999 |pmid= 10207129 |doi=
*cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue= |pages= 177–244 |year= 2000 |pmid= 10730216 |doi=
*cite journal | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993–1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635
*cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155–64 |year= 2001 |pmid= 11256076 |doi=
*cite journal | author=Kinch MS, Carles-Kinch K |title=Overexpression and functional alterations of the EphA2 tyrosine kinase in cancer. |journal=Clin. Exp. Metastasis |volume=20 |issue= 1 |pages= 59–68 |year= 2003 |pmid= 12650608 |doi=
*cite journal | author=Walker-Daniels J, Hess AR, Hendrix MJ, Kinch MS |title=Differential regulation of EphA2 in normal and malignant cells. |journal=Am. J. Pathol. |volume=162 |issue= 4 |pages= 1037–42 |year= 2003 |pmid= 12651595 |doi=
*cite journal | author=Lindberg RA, Hunter T |title=cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. |journal=Mol. Cell. Biol. |volume=10 |issue= 12 |pages= 6316–24 |year= 1991 |pmid= 2174105 |doi=
*cite journal | author=Pandey A, Shao H, Marks RM, "et al." |title=Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis. |journal=Science |volume=268 |issue= 5210 |pages= 567–9 |year= 1995 |pmid= 7536959 |doi=
*cite journal | author=Pandey A, Duan H, Dixit VM |title=Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase. |journal=J. Biol. Chem. |volume=270 |issue= 33 |pages= 19201–4 |year= 1995 |pmid= 7543898 |doi=
*cite journal | author=Ruiz JC, Robertson EJ |title=The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development. |journal=Mech. Dev. |volume=46 |issue= 2 |pages= 87–100 |year= 1994 |pmid= 7918100 |doi=
*cite journal | author=Davis S, Gale NW, Aldrich TH, "et al." |title=Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. |journal=Science |volume=266 |issue= 5186 |pages= 816–9 |year= 1994 |pmid= 7973638 |doi=
*cite journal | author=Pandey A, Lazar DF, Saltiel AR, Dixit VM |title=Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity. |journal=J. Biol. Chem. |volume=269 |issue= 48 |pages= 30154–7 |year= 1994 |pmid= 7982920 |doi=
*cite journal | author=Ganju P, Shigemoto K, Brennan J, "et al." |title=The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development. |journal=Oncogene |volume=9 |issue= 6 |pages= 1613–24 |year= 1994 |pmid= 8183555 |doi=
*cite journal | author=Gale NW, Holland SJ, Valenzuela DM, "et al." |title=Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. |journal=Neuron |volume=17 |issue= 1 |pages= 9–19 |year= 1996 |pmid= 8755474 |doi=
*cite journal | author=Sulman EP, Tang XX, Allen C, "et al." |title=ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers. |journal=Genomics |volume=40 |issue= 2 |pages= 371–4 |year= 1997 |pmid= 9119409 |doi= 10.1006/geno.1996.4569
*cite journal | author=Kozlosky CJ, VandenBos T, Park L, "et al." |title=LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain. |journal=Cytokine |volume=9 |issue= 8 |pages= 540–9 |year= 1997 |pmid= 9245480 |doi= 10.1006/cyto.1997.0199
*cite journal | author= |title=Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. |journal=Cell |volume=90 |issue= 3 |pages= 403–4 |year= 1997 |pmid= 9267020 |doi=

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