EPH receptor A2

EPH receptor A2

EPH receptor A2, also known as EPHA2, is a human gene. [cite web | title = Entrez Gene: EPHA2 EPH receptor A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1969| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands.cite web | title = Entrez Gene: EPHA2 EPH receptor A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1969| accessdate = ]

References

PBB_Further_reading
citations =
*cite journal | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue= |pages= 309–45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309
*cite journal | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151–81 |year= 1998 |pmid= 9576626 |doi=
*cite journal | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033–44 |year= 1999 |pmid= 10207129 |doi=
*cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue= |pages= 177–244 |year= 2000 |pmid= 10730216 |doi=
*cite journal | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993–1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635
*cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155–64 |year= 2001 |pmid= 11256076 |doi=
*cite journal | author=Kinch MS, Carles-Kinch K |title=Overexpression and functional alterations of the EphA2 tyrosine kinase in cancer. |journal=Clin. Exp. Metastasis |volume=20 |issue= 1 |pages= 59–68 |year= 2003 |pmid= 12650608 |doi=
*cite journal | author=Walker-Daniels J, Hess AR, Hendrix MJ, Kinch MS |title=Differential regulation of EphA2 in normal and malignant cells. |journal=Am. J. Pathol. |volume=162 |issue= 4 |pages= 1037–42 |year= 2003 |pmid= 12651595 |doi=
*cite journal | author=Lindberg RA, Hunter T |title=cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. |journal=Mol. Cell. Biol. |volume=10 |issue= 12 |pages= 6316–24 |year= 1991 |pmid= 2174105 |doi=
*cite journal | author=Pandey A, Shao H, Marks RM, "et al." |title=Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis. |journal=Science |volume=268 |issue= 5210 |pages= 567–9 |year= 1995 |pmid= 7536959 |doi=
*cite journal | author=Pandey A, Duan H, Dixit VM |title=Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase. |journal=J. Biol. Chem. |volume=270 |issue= 33 |pages= 19201–4 |year= 1995 |pmid= 7543898 |doi=
*cite journal | author=Ruiz JC, Robertson EJ |title=The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development. |journal=Mech. Dev. |volume=46 |issue= 2 |pages= 87–100 |year= 1994 |pmid= 7918100 |doi=
*cite journal | author=Davis S, Gale NW, Aldrich TH, "et al." |title=Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. |journal=Science |volume=266 |issue= 5186 |pages= 816–9 |year= 1994 |pmid= 7973638 |doi=
*cite journal | author=Pandey A, Lazar DF, Saltiel AR, Dixit VM |title=Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity. |journal=J. Biol. Chem. |volume=269 |issue= 48 |pages= 30154–7 |year= 1994 |pmid= 7982920 |doi=
*cite journal | author=Ganju P, Shigemoto K, Brennan J, "et al." |title=The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development. |journal=Oncogene |volume=9 |issue= 6 |pages= 1613–24 |year= 1994 |pmid= 8183555 |doi=
*cite journal | author=Gale NW, Holland SJ, Valenzuela DM, "et al." |title=Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. |journal=Neuron |volume=17 |issue= 1 |pages= 9–19 |year= 1996 |pmid= 8755474 |doi=
*cite journal | author=Sulman EP, Tang XX, Allen C, "et al." |title=ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers. |journal=Genomics |volume=40 |issue= 2 |pages= 371–4 |year= 1997 |pmid= 9119409 |doi= 10.1006/geno.1996.4569
*cite journal | author=Kozlosky CJ, VandenBos T, Park L, "et al." |title=LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain. |journal=Cytokine |volume=9 |issue= 8 |pages= 540–9 |year= 1997 |pmid= 9245480 |doi= 10.1006/cyto.1997.0199
*cite journal | author= |title=Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. |journal=Cell |volume=90 |issue= 3 |pages= 403–4 |year= 1997 |pmid= 9267020 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • EPH receptor B1 — EPH receptor B1, also known as EPHB1, is a human gene.cite web | title = Entrez Gene: EPHB1 EPH receptor B1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2047| accessdate = ] PBB Summary section title =… …   Wikipedia

  • EPH receptor A4 — EPH receptor A4, also known as EPHA4, is a human gene.cite web | title = Entrez Gene: EPHA4 EPH receptor A4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2043| accessdate = ] PBB Summary section title =… …   Wikipedia

  • EPH receptor B4 — EPH receptor B4, also known as EPHB4, is a human gene.cite web | title = Entrez Gene: EPHB4 EPH receptor B4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2050| accessdate = ] PBB Summary section title =… …   Wikipedia

  • EPH receptor B2 — EPH receptor B2, also known as EPHB2, is a human gene.Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are …   Wikipedia

  • Eph receptor — In molecular biology, ephrins and Eph receptors are components of cell signaling pathways involved in animal development, and implicated in some cancers. Eph receptors are classified as receptor tyrosine kinases (RTKs), and form the largest sub… …   Wikipedia

  • Eph — may refer to:*Eph receptor, a component of cell signaling pathways involved in animal development *Ephs, athletic teams at Williams College …   Wikipedia

  • Receptor (biochemistry) — For other uses, see Receptor (disambiguation). In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism. These signals… …   Wikipedia

  • EPH — Class of receptor tyrosine kinases (Nuk, ) implicated in control of axon guidance, regulation of cell migration and defining compartments in embryogenesis. Ligands are generally cell bound and include Elk L and Htk L. Interaction of receptor and… …   Dictionary of molecular biology

  • Cell surface receptor — The seven transmembrane α helix structure of a G protein coupled receptor Cell surface receptors (membrane receptors, transmembrane receptors) are specialized integral membrane proteins that take part in communication between the cell and the… …   Wikipedia

  • TrkC receptor — Neurotrophic tyrosine kinase, receptor, type 3 PDB rendering based on 1wwc …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”