EPH receptor B4

EPH receptor B4

EPH receptor B4, also known as EPHB4, is a human gene.cite web | title = Entrez Gene: EPHB4 EPH receptor B4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2050| accessdate = ]

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summary_text = Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.cite web | title = Entrez Gene: EPHB4 EPH receptor B4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2050| accessdate = ]

References

Further reading

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citations =
*cite journal | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue= |pages= 309–45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309
*cite journal | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151–81 |year= 1998 |pmid= 9576626 |doi=
*cite journal | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033–44 |year= 1999 |pmid= 10207129 |doi=
*cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue= |pages= 177–244 |year= 2000 |pmid= 10730216 |doi=
*cite journal | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993–1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635
*cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155–64 |year= 2001 |pmid= 11256076 |doi=
*cite journal | author=Andres AC, Reid HH, Zürcher G, "et al." |title=Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis. |journal=Oncogene |volume=9 |issue= 5 |pages= 1461–7 |year= 1994 |pmid= 8152808 |doi=
*cite journal | author=Bennett BD, Wang Z, Kuang WJ, "et al." |title=Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily. |journal=J. Biol. Chem. |volume=269 |issue= 19 |pages= 14211–8 |year= 1994 |pmid= 8188704 |doi=
*cite journal | author=Berclaz G, Andres AC, Albrecht D, "et al." |title=Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium. |journal=Biochem. Biophys. Res. Commun. |volume=226 |issue= 3 |pages= 869–75 |year= 1996 |pmid= 8831703 |doi= 10.1006/bbrc.1996.1442
*cite journal | author= |title=Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. |journal=Cell |volume=90 |issue= 3 |pages= 403–4 |year= 1997 |pmid= 9267020 |doi=
*cite journal | author=Nikolova Z, Djonov V, Zuercher G, "et al." |title=Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin-B2 during mammary gland morphogenesis. |journal=J. Cell. Sci. |volume=111 ( Pt 18) |issue= |pages= 2741–51 |year= 1998 |pmid= 9718367 |doi=
*cite journal | author=Tang XX, Brodeur GM, Campling BG, Ikegaki N |title=Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma. |journal=Clin. Cancer Res. |volume=5 |issue= 2 |pages= 455–60 |year= 1999 |pmid= 10037197 |doi=
*cite journal | author=Gerety SS, Wang HU, Chen ZF, Anderson DJ |title=Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. |journal=Mol. Cell |volume=4 |issue= 3 |pages= 403–14 |year= 1999 |pmid= 10518221 |doi=
*cite journal | author=Dalva MB, Takasu MA, Lin MZ, "et al." |title=EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. |journal=Cell |volume=103 |issue= 6 |pages= 945–56 |year= 2001 |pmid= 11136979 |doi=
*cite journal | author=Wilson MD, Riemer C, Martindale DW, "et al." |title=Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. |journal=Nucleic Acids Res. |volume=29 |issue= 6 |pages= 1352–65 |year= 2001 |pmid= 11239002 |doi=

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