- Angiopoietin receptor
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tyrosine kinase with immunoglobulin-like and EGF-like domains 1 Identifiers Symbol TIE1 Alt. symbols TIE, JTK14 Entrez 7075 HUGO 11809 OMIM 600222 RefSeq NM_005424 UniProt P35590 Other data EC number 2.7.1.112 Locus Chr. 1 p34-p33 TEK tyrosine kinase, endothelial Identifiers Symbol TEK Alt. symbols TIE2, TIE-2, VMCM1, CD202b Entrez 7010 HUGO 11724 OMIM 600221 RefSeq NM_000459 UniProt Q02763 Other data Locus Chr. 9 p21 The angiopoietin receptors are receptors that bind angiopoietin.
TIE-1 and TIE-2 comprise the cell-surface receptors that bind and are activated by the angiopoietins, (Ang1, Ang2, Ang3, Ang4). The angiopoietins are protein growth factors required for the formation of blood vessels (angiogenesis).
Angiopoietins
The angiopoietins are protein growth factors that promote angiogenesis, the formation of blood vessels. There are now four identified angiopoietins: Ang1, Ang2, Ang3, Ang4. Ang1 and Ang4 function as agonistic or activating ligands for Tie2, whereas Ang2 and Ang3 behave as competitive antagonists. They function by binding their physiologic receptors, Tie-1 and Tie-2. These are receptor tyrosine kinases, so named because they mediate cell signals by inducing the phosphorylation of key tyrosines, thus initiating cell signalling. It is somewhat controversial which of the Tie receptors mediate functional signals downstream of Ang stimulation. But it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietins.
External links
Protein kinases: tyrosine kinases (EC 2.7.10) Receptor tyrosine kinases (EC 2.7.10.1) Insulin receptor familyPDGF receptor familyFGF receptor familyVEGF receptors familyHGF receptor familyTrk receptor familyEPH receptor familyLTK receptor familyTIE receptor familyROR receptor familyDDR receptor familyPTK7 receptor familyRYK receptor familyMuSK receptor familyROS receptor familyAATYK receptor familyAXL receptor familyRET receptor familyuncatagorisedNon-receptor tyrosine kinases (EC 2.7.10.2) ABL familyACK familyCSK familyFAK familyFES familyFRK familyJAK familySRC-A familySRC-B familyTEC familySYK familyCategories:- Genes on chromosome 1
- Genes on chromosome 9
- Tyrosine kinase receptors
- Proteins
- Developmental neuroscience
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