Tyrosine kinase 2

Tyrosine kinase 2

Tyrosine kinase 2, also known as TYK2, is a human gene.cite web | title = Entrez Gene: TYK2 tyrosine kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7297| accessdate = ]

Tyk2 was the first member of the JAK family that was described. It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling.

External links



Further reading

citations =
*cite journal | author=Velazquez L, Fellous M, Stark GR, Pellegrini S |title=A protein tyrosine kinase in the interferon alpha/beta signaling pathway. |journal=Cell |volume=70 |issue= 2 |pages= 313–22 |year= 1992 |pmid= 1386289 |doi=
*cite journal | author=Krolewski JJ, Lee R, Eddy R, "et al." |title=Identification and chromosomal mapping of new human tyrosine kinase genes. |journal=Oncogene |volume=5 |issue= 3 |pages= 277–82 |year= 1990 |pmid= 2156206 |doi=
*cite journal | author=Firmbach-Kraft I, Byers M, Shows T, "et al." |title=tyk2, prototype of a novel class of non-receptor tyrosine kinase genes. |journal=Oncogene |volume=5 |issue= 9 |pages= 1329–36 |year= 1990 |pmid= 2216457 |doi=
*cite journal | author=Partanen J, Mäkelä TP, Alitalo R, "et al." |title=Putative tyrosine kinases expressed in K-562 human leukemia cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 22 |pages= 8913–7 |year= 1991 |pmid= 2247464 |doi=
*cite journal | author=Colamonici O, Yan H, Domanski P, "et al." |title=Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. |journal=Mol. Cell. Biol. |volume=14 |issue= 12 |pages= 8133–42 |year= 1994 |pmid= 7526154 |doi=
*cite journal | author=Novak U, Harpur AG, Paradiso L, "et al." |title=Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts. |journal=Blood |volume=86 |issue= 8 |pages= 2948–56 |year= 1995 |pmid= 7579387 |doi=
*cite journal | author=Domanski P, Yan H, Witte MM, "et al." |title=Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase. |journal=FEBS Lett. |volume=374 |issue= 3 |pages= 317–22 |year= 1995 |pmid= 7589562 |doi=
*cite journal | author=Yetter A, Uddin S, Krolewski JJ, "et al." |title=Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase. |journal=J. Biol. Chem. |volume=270 |issue= 31 |pages= 18179–82 |year= 1995 |pmid= 7629131 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Trask B, Fertitta A, Christensen M, "et al." |title=Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers. |journal=Genomics |volume=15 |issue= 1 |pages= 133–45 |year= 1993 |pmid= 8432525 |doi=
*cite journal | author=Platanias LC, Uddin S, Yetter A, "et al." |title=The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2. |journal=J. Biol. Chem. |volume=271 |issue= 1 |pages= 278–82 |year= 1996 |pmid= 8550573 |doi=
*cite journal | author=Gauzzi MC, Velazquez L, McKendry R, "et al." |title=Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. |journal=J. Biol. Chem. |volume=271 |issue= 34 |pages= 20494–500 |year= 1996 |pmid= 8702790 |doi=
*cite journal | author=Uddin S, Gardziola C, Dangat A, "et al." |title=Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase. |journal=Biochem. Biophys. Res. Commun. |volume=225 |issue= 3 |pages= 833–8 |year= 1996 |pmid= 8780698 |doi= 10.1006/bbrc.1996.1259
*cite journal | author=Zou J, Presky DH, Wu CY, Gubler U |title=Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases. |journal=J. Biol. Chem. |volume=272 |issue= 9 |pages= 6073–7 |year= 1997 |pmid= 9038232 |doi=
*cite journal | author=Miyakawa Y, Oda A, Druker BJ, "et al." |title=Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets. |journal=Blood |volume=89 |issue= 8 |pages= 2789–98 |year= 1997 |pmid= 9108397 |doi=
*cite journal | author=Uddin S, Sher DA, Alsayed Y, "et al." |title=Interaction of p59fyn with interferon-activated Jak kinases. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 1 |pages= 83–8 |year= 1997 |pmid= 9196040 |doi= 10.1006/bbrc.1997.6741
*cite journal | author=Burfoot MS, Rogers NC, Watling D, "et al." |title=Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24183–90 |year= 1997 |pmid= 9305869 |doi=
*cite journal | author=Gauzzi MC, Barbieri G, Richter MF, "et al." |title=The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 22 |pages= 11839–44 |year= 1997 |pmid= 9342324 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Ahmad S, Alsayed YM, Druker BJ, Platanias LC |title=The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein. |journal=J. Biol. Chem. |volume=272 |issue= 48 |pages= 29991–4 |year= 1997 |pmid= 9374471 |doi=

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