Related to receptor tyrosine kinase
- Related to receptor tyrosine kinase
protein
name=RYK receptor-like tyrosine kinase
caption=
width=
HGNCid=10481
Symbol=RYK
AltSymbols=JTK5A
EntrezGene=6259
OMIM=600524
RefSeq=NM_001005861
UniProt=
PDB=
ECnumber=2.7.1.112
Chromosome=3
Arm=q
Band=22.1
LocusSupplementaryData=The related to receptor tyrosine kinases (RYKs) are a family of proteins that are a members of the receptor tyrosine kinase family of cell surface receptors.
History
The gene encoding mouse RYK was first identified in 1992.[cite journal | author = Hovens, CM, Stacker, SA | title =RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs | journal =Proc. Natl. Acad. Sci. USA. | year=1992 | volume=89 | issue=24 | pages=11818–11822 | pmid = 1334548 | doi =10.1073/pnas.89.24.11818] Subsequently cDNA encoding the RYK protein have been isolated from the following species.][cite journal | author = Halford, MM, and Stacker, S.A. | title =Revelations of the RYK receptor | journal =Bioessays | year=2001 | volume=23 | issue=1 | pages=34–45 | pmid = 11135307 | doi =10.1002/1521-1878(200101)23:1<34::AID-BIES1005>3.0.CO;2-D | doilabel =10.1002/1521-1878(200101)23:134::AID-BIES10053.0.CO;2-D] ]
*rat
*chicken
*Human
*Zebrafish
*"Drosophila" and
*"C. elegans"
tructure
In common with other receptor tyrosine kinase family members, RYK is composed of three domains, an N-terminal extracellular ligand binding domain, a transmembrane spanning domain and a C-terminal intracellular domain. However, in contrast to other receptor tyrosine kinases the C-terminal domain of RYK is devoid of detectable kinase activity.
References
Wikimedia Foundation.
2010.
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