Megakaryocyte-associated tyrosine kinase

Megakaryocyte-associated tyrosine kinase
Megakaryocyte-associated tyrosine kinase

PDB rendering based on 1jwo.
Symbols MATK; CHK; CTK; DKFZp434N1212; HHYLTK; HYL; HYLTK; Lsk; MGC1708; MGC2101
External IDs OMIM600038 MGI99259 HomoloGene48104 GeneCards: MATK Gene
EC number
RNA expression pattern
PBB GE MATK 206267 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4145 17179
Ensembl ENSG00000007264 ENSMUSG00000004933
UniProt P42679 P70223
RefSeq (mRNA) NM_002378.3 NM_010768.1
RefSeq (protein) NP_002369.2 NP_034898.1
Location (UCSC) Chr 19:
3.78 – 3.8 Mb
Chr 10:
80.72 – 80.73 Mb
PubMed search [1] [2]

Megakaryocyte-associated tyrosine-protein kinase is an enzyme that in humans is encoded by the MATK gene.[1][2][3]

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.[3]


Megakaryocyte-associated tyrosine kinase has been shown to interact with CD117[4][5] and TrkA.[6]


  1. ^ Bennett BD, Cowley S, Jiang S, London R, Deng B, Grabarek J, Groopman JE, Goeddel DV, Avraham H (Feb 1994). "Identification and characterization of a novel tyrosine kinase from megakaryocytes". J Biol Chem 269 (2): 1068–74. PMID 8288563. 
  2. ^ Avraham S, Jiang S, Ota S, Fu Y, Deng B, Dowler LL, White RA, Avraham H (Feb 1995). "Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product". J Biol Chem 270 (4): 1833–42. doi:10.1074/jbc.270.4.1833. PMID 7530249. 
  3. ^ a b "Entrez Gene: MATK megakaryocyte-associated tyrosine kinase". 
  4. ^ Jhun, B H; Rivnay B, Price D, Avraham H (Apr. 1995). "The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit". J. Biol. Chem. (UNITED STATES) 270 (16): 9661–6. doi:10.1074/jbc.270.16.9661. ISSN 0021-9258. PMID 7536744. 
  5. ^ Price, D J; Rivnay B, Fu Y, Jiang S, Avraham S, Avraham H (Feb. 1997). "Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes". J. Biol. Chem. (UNITED STATES) 272 (9): 5915–20. doi:10.1074/jbc.272.9.5915. ISSN 0021-9258. PMID 9038210. 
  6. ^ Yamashita, H; Avraham S, Jiang S, Dikic I, Avraham H (May. 1999). "The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells". J. Biol. Chem. (UNITED STATES) 274 (21): 15059–65. doi:10.1074/jbc.274.21.15059. ISSN 0021-9258. PMID 10329710. 

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