- GPVI
GPVI is a
gene which codesglycoprotein VI, a glycoprotein receptor forcollagen found onplatelets .PBB_Summary
section_title =
summary_text = Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000). [supplied by OMIM] [cite web | title = Entrez Gene: GP6 glycoprotein VI (platelet)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51206| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Nieswandt B, Watson SP |title=Platelet-collagen interaction: is GPVI the central receptor? |journal=Blood |volume=102 |issue= 2 |pages= 449–61 |year= 2003 |pmid= 12649139 |doi= 10.1182/blood-2002-12-3882
*cite journal | author=Watson SP, Auger JM, McCarty OJ, Pearce AC |title=GPVI and integrin alphaIIb beta3 signaling in platelets. |journal=J. Thromb. Haemost. |volume=3 |issue= 8 |pages= 1752–62 |year= 2005 |pmid= 16102042 |doi= 10.1111/j.1538-7836.2005.01429.x
*cite journal | author=Huang MM, Bolen JB, Barnwell JW, "et al." |title=Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 17 |pages= 7844–8 |year= 1991 |pmid= 1715582 |doi=
*cite journal | author=Moroi M, Jung SM, Okuma M, Shinmyozu K |title=A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion. |journal=J. Clin. Invest. |volume=84 |issue= 5 |pages= 1440–5 |year= 1989 |pmid= 2808700 |doi=
*cite journal | author=Polgár J, Clemetson JM, Kehrel BE, "et al." |title=Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor. |journal=J. Biol. Chem. |volume=272 |issue= 21 |pages= 13576–83 |year= 1997 |pmid= 9153205 |doi=
*cite journal | author=Gibbins JM, Okuma M, Farndale R, "et al." |title=Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain. |journal=FEBS Lett. |volume=413 |issue= 2 |pages= 255–9 |year= 1997 |pmid= 9280292 |doi=
*cite journal | author=Tsuji M, Ezumi Y, Arai M, Takayama H |title=A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets. |journal=J. Biol. Chem. |volume=272 |issue= 38 |pages= 23528–31 |year= 1997 |pmid= 9295288 |doi=
*cite journal | author=Clemetson JM, Polgar J, Magnenat E, "et al." |title=The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors. |journal=J. Biol. Chem. |volume=274 |issue= 41 |pages= 29019–24 |year= 1999 |pmid= 10506151 |doi=
*cite journal | author=Miura Y, Ohnuma M, Jung SM, Moroi M |title=Cloning and expression of the platelet-specific collagen receptor glycoprotein VI. |journal=Thromb. Res. |volume=98 |issue= 4 |pages= 301–9 |year= 2000 |pmid= 10822077 |doi=
*cite journal | author=Nieswandt B, Bergmeier W, Schulte V, "et al." |title=Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23998–4002 |year= 2000 |pmid= 10825177 |doi= 10.1074/jbc.M003803200
*cite journal | author=Jandrot-Perrus M, Busfield S, Lagrue AH, "et al." |title=Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. |journal=Blood |volume=96 |issue= 5 |pages= 1798–807 |year= 2000 |pmid= 10961879 |doi=
*cite journal | author=Ezumi Y, Uchiyama T, Takayama H |title=Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI. |journal=Biochem. Biophys. Res. Commun. |volume=277 |issue= 1 |pages= 27–36 |year= 2000 |pmid= 11027634 |doi= 10.1006/bbrc.2000.3624
*cite journal | author=Barry FA, Gibbins JM |title=Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 12874–8 |year= 2002 |pmid= 11825911 |doi= 10.1074/jbc.M200482200
*cite journal | author=Suzuki-Inoue K, Tulasne D, Shen Y, "et al." |title=Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21561–6 |year= 2002 |pmid= 11943772 |doi= 10.1074/jbc.M201012200
*cite journal | author=Quinton TM, Ozdener F, Dangelmaier C, "et al." |title=Glycoprotein VI-mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP. |journal=Blood |volume=99 |issue= 9 |pages= 3228–34 |year= 2002 |pmid= 11964287 |doi=
*cite journal | author=Saving KL, Mankin PE, Gorman MJ |title=Differences in adhesion receptor expression between immature and older platelets and red blood cells of neonates and adults. |journal=J. Pediatr. Hematol. Oncol. |volume=24 |issue= 2 |pages= 120–4 |year= 2002 |pmid= 11990697 |doi=
*cite journal | author=Andrews RK, Suzuki-Inoue K, Shen Y, "et al." |title=Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI. |journal=Blood |volume=99 |issue= 11 |pages= 4219–21 |year= 2002 |pmid= 12010829 |doi= 10.1182/blood-2001-11-0008
*cite journal | author=Wonerow P, Obergfell A, Wilde JI, "et al." |title=Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets. |journal=Biochem. J. |volume=364 |issue= Pt 3 |pages= 755–65 |year= 2002 |pmid= 12049640 |doi= 10.1042/BJ20020128
*cite journal | author=Miura Y, Takahashi T, Jung SM, Moroi M |title=Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46197–204 |year= 2003 |pmid= 12356768 |doi= 10.1074/jbc.M204029200
*cite journal | author=Holmes ML, Bartle N, Eisbacher M, Chong BH |title=Cloning and analysis of the thrombopoietin-induced megakaryocyte-specific glycoprotein VI promoter and its regulation by GATA-1, Fli-1, and Sp1. |journal=J. Biol. Chem. |volume=277 |issue= 50 |pages= 48333–41 |year= 2003 |pmid= 12359731 |doi= 10.1074/jbc.M206127200PBB_Controls
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