ITGA2B

Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), also known as ITGA2B, is a human gene.

PBB_Summary
section_title =
summary_text = ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [cite web | title = Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3674| accessdate = ]

ee also

* Cluster of differentiation
* Glycoprotein IIb/IIIa

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bray PF |title=Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization. |journal=Thromb. Haemost. |volume=72 |issue= 4 |pages= 492–502 |year= 1995 |pmid= 7878622 |doi=
*cite journal | author=Naik UP, Parise LV |title=Structure and function of platelet alpha IIb beta 3. |journal=Curr. Opin. Hematol. |volume=4 |issue= 5 |pages= 317–22 |year= 1997 |pmid= 9288464 |doi=
*cite journal | author=Porter JC, Hogg N |title=Integrins take partners: cross-talk between integrins and other membrane receptors. |journal=Trends Cell Biol. |volume=8 |issue= 10 |pages= 390–6 |year= 1999 |pmid= 9789327 |doi=
*cite journal | author=Lincoff AM |title=Trials of platelet glycoprotein IIb/IIIa receptor antagonists during percutaneous coronary revascularization. |journal=Am. J. Cardiol. |volume=82 |issue= 8B |pages= 36P–42P |year= 1998 |pmid= 9809890 |doi=
*cite journal | author=Bennett JS |title=Platelet-fibrinogen interactions. |journal=Ann. N. Y. Acad. Sci. |volume=936 |issue= |pages= 340–54 |year= 2001 |pmid= 11460491 |doi=
*cite journal | author=Plow EF, Cierniewski CS, Xiao Z, "et al." |title=AlphaIIbbeta3 and its antagonism at the new millennium. |journal=Thromb. Haemost. |volume=86 |issue= 1 |pages= 34–40 |year= 2002 |pmid= 11487023 |doi=
*cite journal | author=Quinn MJ, Byzova TV, Qin J, "et al." |title=Integrin alphaIIbbeta3 and its antagonism. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=23 |issue= 6 |pages= 945–52 |year= 2004 |pmid= 12637342 |doi= 10.1161/01.ATV.0000066686.46338.F1
*cite journal | author=Fullard JF |title=The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis. |journal=Curr. Pharm. Des. |volume=10 |issue= 14 |pages= 1567–76 |year= 2004 |pmid= 15134555 |doi=
*cite journal | author=Watson SP, Auger JM, McCarty OJ, Pearce AC |title=GPVI and integrin alphaIIb beta3 signaling in platelets. |journal=J. Thromb. Haemost. |volume=3 |issue= 8 |pages= 1752–62 |year= 2005 |pmid= 16102042 |doi= 10.1111/j.1538-7836.2005.01429.x
*cite journal | author=Bennett JS |title=Structure and function of the platelet integrin alphaIIbbeta3. |journal=J. Clin. Invest. |volume=115 |issue= 12 |pages= 3363–9 |year= 2006 |pmid= 16322781 |doi= 10.1172/JCI26989
*cite journal | author=Ma YQ, Qin J, Plow EF |title=Platelet integrin alpha(IIb)beta(3): activation mechanisms. |journal=J. Thromb. Haemost. |volume=5 |issue= 7 |pages= 1345–52 |year= 2007 |pmid= 17635696 |doi= 10.1111/j.1538-7836.2007.02537.x

External links

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