Glycoprotein IIb/IIIa

protein
Name = integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
caption =


width =
HGNCid = 6138
Symbol = ITGA2B
AltSymbols = GP2B
EntrezGene = 3674
OMIM = 607759
RefSeq = NM_000419
UniProt = P08514
PDB =
ECnumber =
Chromosome = 17
Arm = q
Band = 21.32
LocusSupplementaryData = protein
Name = integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
caption =


width =
HGNCid = 6156
Symbol = ITGB3
AltSymbols = GP3A
EntrezGene = 3690
OMIM = 173470
RefSeq = NM_000212
UniProt = P05106
PDB =
ECnumber =
Chromosome = 17
Arm = q
Band = 21.32
LocusSupplementaryData = In medicine, glycoprotein IIb/IIIa, also gpIIb/IIIa, is an integrin found on platelets. Calcium-dependent association of gpIIb and gpIIIa is required for normal platelet aggregation and endothelial adherence.cite journal | author = Calvete JJ | title = On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor | journal = Proc. Soc. Exp. Biol. Med. | volume = 208 | issue = 4 | pages = 346–60 | year = 1995 | pmid = 7535429 | doi = | issn = ] cite journal | author = Shattil SJ | title = Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways | journal = Thromb. Haemost. | volume = 82 | issue = 2 | pages = 318–25 | year = 1999 | pmid = 10605720 | doi = | issn = ]

Pathology

Defects in glycoprotein IIb/IIIa causes Glanzmann's thrombasthenia.cite journal | author = Bellucci S, Caen J | title = Molecular basis of Glanzmann's Thrombasthenia and current strategies in treatment | journal = Blood Rev. | volume = 16 | issue = 3 | pages = 193–202 | year = 2002 | pmid = 12163005 | doi = 10.1016/S0268-960X(02)00030-9 | issn = ]

Medicine

Glycoprotein IIb/IIIa inhibitors can be used to prevent blood clots in an effort to decrease the risk of heart attack or stroke.

ee also

*Glycoprotein IIb/IIIa inhibitors

References

External links

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