Macrophage-1 antigen

Macrophage-1 antigen (or integrin alphaMbeta2) is a complement receptor ("CR3") consisting of CD11b and CD18.^[1]

It binds to C3b and C4b.

Function

Complement receptor 3 (CR3)(CD11b/CD18) is a human cell surface receptor found on polymorphonuclear leukocytes (mostly neutrophils), NK cells, and mononuclear phagocytes like macrophages. CR3 is a pattern recognition receptor, capable of recognizing and binding to many molecules found on the surfaces of invading bacteria. CR3 also recognizes iC3b when bound to the surface of foreign cells. Binding to the receptor causes phagocytosis and destruction of the foreign cell.

CR3 belongs to a family of cell surface receptors known as integrins (because they share this particular β chain, they are referred to as β2-integrins), which are extremely widely distributed throughout nature and which generally are important in cellular adhesion and cell-cell interactions in a variety of cells and circumstances.

Upregulation of MAC-1 in the presence of certain factors such as Il-2 may cause a prolongation of the life of the immune cell while the presence of TNF-alpha induces apoptosis and selective removal of the cell.

A fully activated neutrophil may express on its membrane 200,000 or more CR3 molecules.

Absence of CR3 results in reduced binding and ingestion of Mycobacterium tuberculosis (in mice).

Synonyms and abbreviations

• CR3
• CD11b/CD18
• Macrophage 1 antigen (Mac-1)

See also

• Macrophage

References

1. ^ Todd R (1996). "The continuing saga of complement receptor type 3 (CR3)". J. Clin. Invest. 98 (1): 1–2. doi:10.1172/JCI118752. PMC 507390. PMID 8690779. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=507390. 

Further reading

• Wagner C, Hänsch GM, Stegmaier S, Denefleh B, Hug F, Schoels M (April 2001). "The complement receptor 3, CR3 (CD11b/CD18), on T lymphocytes: activation-dependent up-regulation and regulatory function". Eur. J. Immunol. 31 (4): 1173–80. doi:10.1002/1521-4141(200104)31:4<1173::AID-IMMU1173>3.0.CO;2-9. PMID 11298342. 
• Rooyakkers AW, Stokes RW (September 2005). "Absence of complement receptor 3 results in reduced binding and ingestion of Mycobacterium tuberculosis but has no significant effect on the induction of reactive oxygen and nitrogen intermediates or on the survival of the bacteria in resident and interferon-gamma activated macrophages". Microb. Pathog. 39 (3): 57–67. doi:10.1016/j.micpath.2005.05.001. PMID 16084683. 

External links

• MeSH Macrophage-1+antigen