- ITGB8
Integrin, beta 8, also known as ITGB8, is a human
gene .cite web | title = Entrez Gene: ITGB8 integrin, beta 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3696| accessdate = ]PBB_Summary
section_title =
summary_text = This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.cite web | title = Entrez Gene: ITGB8 integrin, beta 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3696| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Moyle M, Napier MA, McLean JW |title=Cloning and expression of a divergent integrin subunit beta 8. |journal=J. Biol. Chem. |volume=266 |issue= 29 |pages= 19650–8 |year= 1991 |pmid= 1918072 |doi=
*cite journal | author=Nishimura SL, Sheppard D, Pytela R |title=Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain. |journal=J. Biol. Chem. |volume=269 |issue= 46 |pages= 28708–15 |year= 1994 |pmid= 7525578 |doi=
*cite journal | author=Pilewski JM, Latoche JD, Arcasoy SM, Albelda SM |title=Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo. |journal=Am. J. Physiol. |volume=273 |issue= 1 Pt 1 |pages= L256–63 |year= 1997 |pmid= 9252563 |doi=
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Cambier S, Mu DZ, O'Connell D, "et al." |title=A role for the integrin alphavbeta8 in the negative regulation of epithelial cell growth. |journal=Cancer Res. |volume=60 |issue= 24 |pages= 7084–93 |year= 2001 |pmid= 11156415 |doi=
*cite journal | author=Mu D, Cambier S, Fjellbirkeland L, "et al." |title=The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. |journal=J. Cell Biol. |volume=157 |issue= 3 |pages= 493–507 |year= 2002 |pmid= 11970960 |doi= 10.1083/jcb.200109100
*cite journal | author=Jarad G, Wang B, Khan S, "et al." |title=Fas activation induces renal tubular epithelial cell beta 8 integrin expression and function in the absence of apoptosis. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47826–33 |year= 2003 |pmid= 12324452 |doi= 10.1074/jbc.M204901200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Fjellbirkeland L, Cambier S, Broaddus VC, "et al." |title=Integrin alphavbeta8-mediated activation of transforming growth factor-beta inhibits human airway epithelial proliferation in intact bronchial tissue. |journal=Am. J. Pathol. |volume=163 |issue= 2 |pages= 533–42 |year= 2003 |pmid= 12875973 |doi=
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Yan W, Shao R |title=Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation. |journal=J. Biol. Chem. |volume=281 |issue= 28 |pages= 19700–8 |year= 2006 |pmid= 16702213 |doi= 10.1074/jbc.M601856200PBB_Controls
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