ITGAV

Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
Rendering of 1JV2
Available structures PDB 1JV2, 1L5G, 1M1X, 1U8C, 3IJE
Identifiers
Symbols	ITGAV; CD51; DKFZp686A08142; MSK8; VNRA
External IDs	OMIM: 193210 MGI: 96608 HomoloGene: 20510 GeneCards: ITGAV Gene
Gene Ontology Molecular function • opsonin binding • receptor activity • protein binding • insulin-like growth factor I binding • transforming growth factor beta binding • protein kinase C alpha binding Cellular component • plasma membrane • plasma membrane • plasma membrane • integral to plasma membrane • integrin complex • integrin complex • external side of plasma membrane • cell surface • cell surface • membrane Biological process • angiogenesis • blood vessel development • cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • axon guidance • blood coagulation • positive regulation of cell proliferation • negative regulation of macrophage derived foam cell differentiation • negative regulation of lipid storage • negative regulation of lipid transport • entry of bacterium into host cell • negative regulation of apoptosis • interspecies interaction between organisms • negative regulation of low-density lipoprotein particle receptor biosynthetic process • positive regulation of cell adhesion • entry of virus into host cell • negative regulation of lipoprotein metabolic process • regulation of phagocytosis • leukocyte migration • entry of symbiont into host cell by promotion of host phagocytosis • ERK1 and ERK2 cascade • regulation of apoptotic cell clearance Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3685	16410
Ensembl	ENSG00000138448	ENSMUSG00000027087
UniProt	P06756	Q3U4C8
RefSeq (mRNA)	NM_001144999.1	NM_008402.2
RefSeq (protein)	NP_001138471.1	NP_032428.2
Location (UCSC)	Chr 2: 187.45 – 187.55 Mb	Chr 2: 83.56 – 83.65 Mb
PubMed search	[1]	[2]

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.^[1]

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.^[2]

See also

• Cluster of differentiation

References

1. ^ Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (Aug 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest 81 (6): 1993–8. doi:10.1172/JCI113548. PMC 442653. PMID 2454952. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442653. 
2. ^ "Entrez Gene: ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3685. 

Further reading

• Horton MA (1997). "The alpha v beta 3 integrin "vitronectin receptor".". Int. J. Biochem. Cell Biol. 29 (5): 721–5. doi:10.1016/S1357-2725(96)00155-0. PMID 9251239. 
• Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors.". Trends Cell Biol. 8 (10): 390–6. doi:10.1016/S0962-8924(98)01344-0. PMID 9789327. 
• Sajid M, Stouffer GA (2002). "The role of alpha(v)beta3 integrins in vascular healing.". Thromb. Haemost. 87 (2): 187–93. PMID 11858476. 
• Cooper CR, Chay CH, Pienta KJ (2002). "The role of alpha(v)beta(3) in prostate cancer progression.". Neoplasia 4 (3): 191–4. doi:10.1038/sj/neo/7900224. PMC 1531692. PMID 11988838. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1531692. 
• Cacciari B, Spalluto G (2005). "Non peptidic alphavbeta3 antagonists: recent developments.". Curr. Med. Chem. 12 (1): 51–70. PMID 15638730. 

External links

• MeSH CD51+Antigen
• ITGAV Info with links in the Cell Migration Gateway