ITGA9

Integrin, alpha 9, also known as ITGA9, is a human gene.cite web | title = Entrez Gene: ITGA9 integrin, alpha 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3680| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers.cite web | title = Entrez Gene: ITGA9 integrin, alpha 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3680| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Evans JP |title=Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization. |journal=Bioessays |volume=23 |issue= 7 |pages= 628–39 |year= 2001 |pmid= 11462216 |doi= 10.1002/bies.1088
*cite journal | author=Palmer EL, Rüegg C, Ferrando R, "et al." |title=Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle. |journal=J. Cell Biol. |volume=123 |issue= 5 |pages= 1289–97 |year= 1994 |pmid= 8245132 |doi=
*cite journal | author=Hibi K, Yamakawa K, Ueda R, "et al." |title=Aberrant upregulation of a novel integrin alpha subunit gene at 3p21.3 in small cell lung cancer. |journal=Oncogene |volume=9 |issue= 2 |pages= 611–9 |year= 1994 |pmid= 8290272 |doi=
*cite journal | author=Yamakawa K, Takahashi T, Horio Y, "et al." |title=Frequent homozygous deletions in lung cancer cell lines detected by a DNA marker located at 3p21.3-p22. |journal=Oncogene |volume=8 |issue= 2 |pages= 327–30 |year= 1993 |pmid= 8381220 |doi=
*cite journal | author=Yokosaki Y, Monis H, Chen J, Sheppard D |title=Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains. |journal=J. Biol. Chem. |volume=271 |issue= 39 |pages= 24144–50 |year= 1996 |pmid= 8798654 |doi=
*cite journal | author=Yokosaki Y, Matsuura N, Sasaki T, "et al." |title=The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin. |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36328–34 |year= 2000 |pmid= 10593924 |doi=
*cite journal | author=Young BA, Taooka Y, Liu S, "et al." |title=The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner. |journal=Mol. Biol. Cell |volume=12 |issue= 10 |pages= 3214–25 |year= 2002 |pmid= 11598204 |doi=
*cite journal | author=Eto K, Huet C, Tarui T, "et al." |title=Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 17804–10 |year= 2002 |pmid= 11882657 |doi= 10.1074/jbc.M200086200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Majumdar M, Tarui T, Shi B, "et al." |title=Plasmin-induced migration requires signaling through protease-activated receptor 1 and integrin alpha(9)beta(1). |journal=J. Biol. Chem. |volume=279 |issue= 36 |pages= 37528–34 |year= 2004 |pmid= 15247268 |doi= 10.1074/jbc.M401372200
*cite journal | author=Chen C, Young BA, Coleman CS, "et al." |title=Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration. |journal=J. Cell Biol. |volume=167 |issue= 1 |pages= 161–70 |year= 2004 |pmid= 15479742 |doi= 10.1083/jcb.200312166
*cite journal | author=Vlahakis NE, Young BA, Atakilit A, Sheppard D |title=The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1. |journal=J. Biol. Chem. |volume=280 |issue= 6 |pages= 4544–52 |year= 2005 |pmid= 15590642 |doi= 10.1074/jbc.M412816200
*cite journal | author=Yokosaki Y, Tanaka K, Higashikawa F, "et al." |title=Distinct structural requirements for binding of the integrins alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 to osteopontin. |journal=Matrix Biol. |volume=24 |issue= 6 |pages= 418–27 |year= 2005 |pmid= 16005200 |doi= 10.1016/j.matbio.2005.05.005
*cite journal | author=Gulubova M, Vlaykova T |title=Immunohistochemical assessment of fibronectin and tenascin and their integrin receptors alpha5beta1 and alpha9beta1 in gastric and colorectal cancers with lymph node and liver metastases. |journal=Acta Histochem. |volume=108 |issue= 1 |pages= 25–35 |year= 2006 |pmid= 16430945 |doi= 10.1016/j.acthis.2005.12.001

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