CD49a

CD49a is an integrin alpha subunit. It makes up half of the α1β1 integrin duplex.

PBB_Summary
section_title =
summary_text = This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.cite web | title = Entrez Gene: ITGA1 integrin, alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3672| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Virtanen I, Korhonen M, Kariniemi AL, "et al." |title=Integrins in human cells and tumors. |journal=Cell Differ. Dev. |volume=32 |issue= 3 |pages= 215–27 |year= 1991 |pmid= 2099238 |doi=
*cite journal | author=Plenz GA, Deng MC, Robenek H, Völker W |title=Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis. |journal=Atherosclerosis |volume=166 |issue= 1 |pages= 1–11 |year= 2003 |pmid= 12482545 |doi=
*cite journal | author=Clover J, Dodds RA, Gowen M |title=Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture. |journal=J. Cell. Sci. |volume=103 ( Pt 1) |issue= |pages= 267–71 |year= 1992 |pmid= 1429908 |doi=
*cite journal | author=Bodary SC, McLean JW |title=The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line. |journal=J. Biol. Chem. |volume=265 |issue= 11 |pages= 5938–41 |year= 1990 |pmid= 1690718 |doi=
*cite journal | author=Sonnenberg A, Linders CJ, Modderman PW, "et al." |title=Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8. |journal=J. Cell Biol. |volume=110 |issue= 6 |pages= 2145–55 |year= 1990 |pmid= 1693624 |doi=
*cite journal | author=Belkin VM, Belkin AM, Dol'nikova AE, "et al." |title= [Isolation and characteristics of ligand specificity of VLA-1 integrin from human smooth muscles] |journal=Biokhimiia |volume=56 |issue= 12 |pages= 2198–206 |year= 1992 |pmid= 1807406 |doi=
*cite journal | author=Bank I, Roth D, Book M, "et al." |title=Expression and functions of very late antigen 1 in inflammatory joint diseases. |journal=J. Clin. Immunol. |volume=11 |issue= 1 |pages= 29–38 |year= 1991 |pmid= 1827128 |doi=
*cite journal | author=Tabibzadeh S |title=Evidence of T-cell activation and potential cytokine action in human endometrium. |journal=J. Clin. Endocrinol. Metab. |volume=71 |issue= 3 |pages= 645–9 |year= 1990 |pmid= 2144294 |doi=
*cite journal | author=Tawil NJ, Houde M, Blacher R, "et al." |title=Alpha 1 beta 1 integrin heterodimer functions as a dual laminin/collagen receptor in neural cells. |journal=Biochemistry |volume=29 |issue= 27 |pages= 6540–4 |year= 1990 |pmid= 2169872 |doi=
*cite journal | author=Belkin VM, Belkin AM, Koteliansky VE |title=Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development. |journal=J. Cell Biol. |volume=111 |issue= 5 Pt 1 |pages= 2159–70 |year= 1990 |pmid= 2229189 |doi=
*cite journal | author=MacDonald TT, Horton MA, Choy MY, Richman PI |title=Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine. |journal=J. Clin. Pathol. |volume=43 |issue= 4 |pages= 313–5 |year= 1990 |pmid= 2341567 |doi=
*cite journal | author=Takada Y, Strominger JL, Hemler ME |title=The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 10 |pages= 3239–43 |year= 1987 |pmid= 3033641 |doi=
*cite journal | author=Hemler ME, Huang C, Schwarz L |title=The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit. |journal=J. Biol. Chem. |volume=262 |issue= 7 |pages= 3300–9 |year= 1987 |pmid= 3546305 |doi=
*cite journal | author=Kono Y, Yang S, Letarte M, Roberts EA |title=Establishment of a human hepatocyte line derived from primary culture in a collagen gel sandwich culture system. |journal=Exp. Cell Res. |volume=221 |issue= 2 |pages= 478–85 |year= 1996 |pmid= 7493648 |doi= 10.1006/excr.1995.1399
*cite journal | author=Eglinton BA, Roberton DM, Cummins AG |title=Phenotype of T cells, their soluble receptor levels, and cytokine profile of human breast milk. |journal=Immunol. Cell Biol. |volume=72 |issue= 4 |pages= 306–13 |year= 1995 |pmid= 7806264 |doi=
*cite journal | author=Salter DM, Godolphin JL, Gourlay MS |title=Chondrocyte heterogeneity: immunohistologically defined variation of integrin expression at different sites in human fetal knees. |journal=J. Histochem. Cytochem. |volume=43 |issue= 4 |pages= 447–57 |year= 1995 |pmid= 7897185 |doi=
*cite journal | author=Pfaff M, Aumailley M, Specks U, "et al." |title=Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI. |journal=Exp. Cell Res. |volume=206 |issue= 1 |pages= 167–76 |year= 1993 |pmid= 8387021 |doi= 10.1006/excr.1993.1134
*cite journal | author=Briesewitz R, Epstein MR, Marcantonio EE |title=Expression of native and truncated forms of the human integrin alpha 1 subunit. |journal=J. Biol. Chem. |volume=268 |issue= 4 |pages= 2989–96 |year= 1993 |pmid= 8428973 |doi=
*cite journal | author=Langholz O, Röckel D, Mauch C, "et al." |title=Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins. |journal=J. Cell Biol. |volume=131 |issue= 6 Pt 2 |pages= 1903–15 |year= 1996 |pmid= 8557756 |doi=

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes