CD49d

CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor.

PBB_Summary
section_title =
summary_text = The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [cite web | title = Entrez Gene: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3676| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Humphries MJ, Sheridan J, Mould AP, Newham P |title=Mechanisms of VCAM-1 and fibronectin binding to integrin alpha 4 beta 1: implications for integrin function and rational drug design. |journal=Ciba Found. Symp. |volume=189 |issue= |pages= 177–91; discussion 191–9 |year= 1995 |pmid= 7587632 |doi=
*cite journal | author=Oostendorp RA, Dörmer P |title=VLA-4-mediated interactions between normal human hematopoietic progenitors and stromal cells. |journal=Leuk. Lymphoma |volume=24 |issue= 5-6 |pages= 423–35 |year= 1997 |pmid= 9086434 |doi=
*cite journal | author=Porter JC, Hogg N |title=Integrins take partners: cross-talk between integrins and other membrane receptors. |journal=Trends Cell Biol. |volume=8 |issue= 10 |pages= 390–6 |year= 1999 |pmid= 9789327 |doi=
*cite journal | author=Rose DM, Han J, Ginsberg MH |title=Alpha4 integrins and the immune response. |journal=Immunol. Rev. |volume=186 |issue= |pages= 118–24 |year= 2003 |pmid= 12234367 |doi=
*cite journal | author=O'Connor P |title=Natalizumab and the role of alpha 4-integrin antagonism in the treatment of multiple sclerosis. |journal=Expert opinion on biological therapy |volume=7 |issue= 1 |pages= 123–36 |year= 2007 |pmid= 17150024 |doi= 10.1517/14712598.7.1.123
*cite journal | author=Chan BM, Elices MJ, Murphy E, Hemler ME |title=Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY. |journal=J. Biol. Chem. |volume=267 |issue= 12 |pages= 8366–70 |year= 1992 |pmid= 1373725 |doi=
*cite journal | author=Fernández-Ruiz E, Pardo-Manuel de Villena F, Rubio MA, "et al." |title=Mapping of the human VLA-alpha 4 gene to chromosome 2q31-q32. |journal=Eur. J. Immunol. |volume=22 |issue= 2 |pages= 587–90 |year= 1992 |pmid= 1537388 |doi=
*cite journal | author=Rubio M, Nueda A, Vara A, Corbí Lopez AL |title=A single mRNA encodes the alpha 150 and alpha 80/70 forms of the alpha subunit of VLA4. |journal=Eur. J. Immunol. |volume=22 |issue= 4 |pages= 1099–102 |year= 1992 |pmid= 1551405 |doi=
*cite journal | author=Sonnenberg A, Linders CJ, Modderman PW, "et al." |title=Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8. |journal=J. Cell Biol. |volume=110 |issue= 6 |pages= 2145–55 |year= 1990 |pmid= 1693624 |doi=
*cite journal | author=Teixidó J, Parker CM, Kassner PD, Hemler ME |title=Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage. |journal=J. Biol. Chem. |volume=267 |issue= 3 |pages= 1786–91 |year= 1992 |pmid= 1730718 |doi=
*cite journal | author=Rosemblatt M, Vuillet-Gaugler MH, Leroy C, Coulombel L |title=Coexpression of two fibronectin receptors, VLA-4 and VLA-5, by immature human erythroblastic precursor cells. |journal=J. Clin. Invest. |volume=87 |issue= 1 |pages= 6–11 |year= 1991 |pmid= 1824634 |doi=
*cite journal | author=Rosen GD, Birkenmeier TM, Dean DC |title=Characterization of the alpha 4 integrin gene promoter. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 10 |pages= 4094–8 |year= 1991 |pmid= 2034655 |doi=
*cite journal | author=Takada Y, Elices MJ, Crouse C, Hemler ME |title=The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function. |journal=EMBO J. |volume=8 |issue= 5 |pages= 1361–8 |year= 1989 |pmid= 2788572 |doi=
*cite journal | author=Takada Y, Strominger JL, Hemler ME |title=The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 10 |pages= 3239–43 |year= 1987 |pmid= 3033641 |doi=
*cite journal | author=Hemler ME, Huang C, Schwarz L |title=The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit. |journal=J. Biol. Chem. |volume=262 |issue= 7 |pages= 3300–9 |year= 1987 |pmid= 3546305 |doi=
*cite journal | author=Gailit J, Pierschbacher M, Clark RA |title=Expression of functional alpha 4 beta 1 integrin by human dermal fibroblasts. |journal=J. Invest. Dermatol. |volume=100 |issue= 3 |pages= 323–8 |year= 1993 |pmid= 8440915 |doi=
*cite journal | author=Pujades C, Teixidó J, Bazzoni G, Hemler ME |title=Integrin alpha 4 cysteines 278 and 717 modulate VLA-4 ligand binding and also contribute to alpha 4/180 formation. |journal=Biochem. J. |volume=313 ( Pt 3) |issue= |pages= 899–908 |year= 1996 |pmid= 8611173 |doi=
*cite journal | author=Szabo M, McIntyre BW |title=Identification of two variants of the human integrin alpha 4 subunit. |journal=Mol. Immunol. |volume=32 |issue= 17-18 |pages= 1453–4 |year= 1996 |pmid= 8643114 |doi=
*cite journal | author=Mannion BA, Berditchevski F, Kraeft SK, "et al." |title=Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29). |journal=J. Immunol. |volume=157 |issue= 5 |pages= 2039–47 |year= 1996 |pmid= 8757325 |doi=

External links

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