CD11c

CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a human gene.cite web | title = Entrez Gene: ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3687| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.cite web | title = Entrez Gene: ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3687| accessdate = ]

CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.

ee also

* Integrin

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Stewart M, Thiel M, Hogg N |title=Leukocyte integrins. |journal=Curr. Opin. Cell Biol. |volume=7 |issue= 5 |pages= 690–6 |year= 1996 |pmid= 8573344 |doi=
*cite journal | author=Steinman RM, Pack M, Inaba K |title=Dendritic cells in the T-cell areas of lymphoid organs. |journal=Immunol. Rev. |volume=156 |issue= |pages= 25–37 |year= 1997 |pmid= 9176697 |doi=
*cite journal | author=Córbi AL, Lopéz-Rodríguez C |title=CD11c integrin gene promoter activity during myeloid differentiation. |journal=Leuk. Lymphoma |volume=25 |issue= 5-6 |pages= 415–25 |year= 1997 |pmid= 9250811 |doi=
*cite journal | author=Ugarova TP, Yakubenko VP |title=Recognition of fibrinogen by leukocyte integrins. |journal=Ann. N. Y. Acad. Sci. |volume=936 |issue= |pages= 368–85 |year= 2001 |pmid= 11460493 |doi=
*cite journal | author=Valentin A, Lundin K, Patarroyo M, Asjö B |title=The leukocyte adhesion glycoprotein CD18 participates in HIV-1-induced syncytia formation in monocytoid and T cells. |journal=J. Immunol. |volume=144 |issue= 3 |pages= 934–7 |year= 1990 |pmid= 1967280 |doi=
*cite journal | author=Gaidano G, Bergui L, Schena M, "et al." |title=Integrin distribution and cytoskeleton organization in normal and malignant monocytes. |journal=Leukemia |volume=4 |issue= 10 |pages= 682–7 |year= 1990 |pmid= 1976870 |doi=
*cite journal | author=Corbi AL, Garcia-Aguilar J, Springer TA |title=Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule. |journal=J. Biol. Chem. |volume=265 |issue= 5 |pages= 2782–8 |year= 1990 |pmid= 2303426 |doi=
*cite journal | author=Corbi AL, Larson RS, Kishimoto TK, "et al." |title=Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion. |journal=J. Exp. Med. |volume=167 |issue= 5 |pages= 1597–607 |year= 1988 |pmid= 3284962 |doi=
*cite journal | author=Corbi AL, Miller LJ, O'Connor K, "et al." |title=cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95. |journal=EMBO J. |volume=6 |issue= 13 |pages= 4023–8 |year= 1988 |pmid= 3327687 |doi=
*cite journal | author=Miller LJ, Wiebe M, Springer TA |title=Purification and alpha subunit N-terminal sequences of human Mac-1 and p150,95 leukocyte adhesion proteins. |journal=J. Immunol. |volume=138 |issue= 8 |pages= 2381–3 |year= 1987 |pmid= 3549901 |doi=
*cite journal | author=Bilsland CA, Diamond MS, Springer TA |title=The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain. |journal=J. Immunol. |volume=152 |issue= 9 |pages= 4582–9 |year= 1994 |pmid= 7512600 |doi=
*cite journal | author=Lecoanet-Henchoz S, Gauchat JF, Aubry JP, "et al." |title=CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18. |journal=Immunity |volume=3 |issue= 1 |pages= 119–25 |year= 1995 |pmid= 7621072 |doi=
*cite journal | author=Garcìa-Barcina M, Winnock M, Bidaurrazaga I, "et al." |title=Detection of cell-adhesion molecules on human liver-associated lymphocytes. |journal=Immunology |volume=82 |issue= 1 |pages= 95–8 |year= 1994 |pmid= 8045597 |doi=
*cite journal | author=Philippeaux MM, Vesin C, Tacchini-Cottier F, Piguet PF |title=Activated human platelets express beta2 integrin. |journal=Eur. J. Haematol. |volume=56 |issue= 3 |pages= 130–7 |year= 1996 |pmid= 8598231 |doi=
*cite journal | author=de Vree WJ, Fontijne-Dorsman AN, Koster JF, Sluiter W |title=Photodynamic treatment of human endothelial cells promotes the adherence of neutrophils in vitro. |journal=Br. J. Cancer |volume=73 |issue= 11 |pages= 1335–40 |year= 1996 |pmid= 8645576 |doi=
*cite journal | author=Bernstein CN, Sargent M, Gallatin WM |title=Beta2 integrin/ICAM expression in Crohn's disease. |journal=Clin. Immunol. Immunopathol. |volume=86 |issue= 2 |pages= 147–60 |year= 1998 |pmid= 9473377 |doi=
*cite journal | author=Shelley CS, Da Silva N, Georgakis A, "et al." |title=Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb. |journal=Genomics |volume=49 |issue= 2 |pages= 334–6 |year= 1998 |pmid= 9598326 |doi=

External links

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