ITGA7

Integrin, alpha 7, also known as ITGA7, is a human gene.cite web | title = Entrez Gene: ITGA7 integrin, alpha 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3679| accessdate = ]

PBB_Summary
section_title =
summary_text = ITGA7 encodes integrin alpha chain 7. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 7 undergoes post-translational cleavage within the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that binds to the extracellular matrix protein laminin-1. Alpha 7 beta 1 is the major integrin complex expressed in differentiated muscle cells. Splice variants of alpha 7 that differ in both the extracellular and cytoplasmic domains exist in the mouse; however, to date only a single human transcript type has been isolated: it contains extracellular and cytoplasmic domains corresponding to the mouse X2 and B variants, respectively. A unique extracellular splice variant has been identified in human, although it clearly represents a minor species and its biological significance is unclear.cite web | title = Entrez Gene: ITGA7 integrin, alpha 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3679| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Fornaro M, Languino LR |title=Alternatively spliced variants: a new view of the integrin cytoplasmic domain. |journal=Matrix Biol. |volume=16 |issue= 4 |pages= 185–93 |year= 1998 |pmid= 9402008 |doi=
*cite journal | author=Song WK, Wang W, Foster RF, "et al." |title=H36-alpha 7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis. |journal=J. Cell Biol. |volume=117 |issue= 3 |pages= 643–57 |year= 1992 |pmid= 1315319 |doi=
*cite journal | author=Kramer RH, Vu MP, Cheng YF, "et al." |title=Laminin-binding integrin alpha 7 beta 1: functional characterization and expression in normal and malignant melanocytes. |journal=Cell Regul. |volume=2 |issue= 10 |pages= 805–17 |year= 1992 |pmid= 1839357 |doi=
*cite journal | author=Wang W, Wu W, Desai T, "et al." |title=Localization of the alpha 7 integrin gene (ITGA7) on human chromosome 12q13: clustering of integrin and Hox genes implies parallel evolution of these gene families. |journal=Genomics |volume=26 |issue= 3 |pages= 568–70 |year= 1995 |pmid= 7607681 |doi=
*cite journal | author=Song WK, Wang W, Sato H, "et al." |title=Expression of alpha 7 integrin cytoplasmic domains during skeletal muscle development: alternate forms, conformational change, and homologies with serine/threonine kinases and tyrosine phosphatases. |journal=J. Cell. Sci. |volume=106 ( Pt 4) |issue= |pages= 1139–52 |year= 1994 |pmid= 8126096 |doi=
*cite journal | author=Ziober BL, Vu MP, Waleh N, "et al." |title=Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development. |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26773–83 |year= 1994 |pmid= 8253814 |doi=
*cite journal | author=Martin PT, Kaufman SJ, Kramer RH, Sanes JR |title=Synaptic integrins in developing, adult, and mutant muscle: selective association of alpha1, alpha7A, and alpha7B integrins with the neuromuscular junction. |journal=Dev. Biol. |volume=174 |issue= 1 |pages= 125–39 |year= 1996 |pmid= 8626012 |doi= 10.1006/dbio.1996.0057
*cite journal | author=Ziober BL, Chen Y, Kramer RH |title=The laminin-binding activity of the alpha 7 integrin receptor is defined by developmentally regulated splicing in the extracellular domain. |journal=Mol. Biol. Cell |volume=8 |issue= 9 |pages= 1723–34 |year= 1997 |pmid= 9307969 |doi=
*cite journal | author=Basora N, Vachon PH, Herring-Gillam FE, "et al." |title=Relation between integrin alpha7Bbeta1 expression in human intestinal cells and enterocytic differentiation. |journal=Gastroenterology |volume=113 |issue= 5 |pages= 1510–21 |year= 1997 |pmid= 9352853 |doi=
*cite journal | author=Mayer U, Saher G, Fässler R, "et al." |title=Absence of integrin alpha 7 causes a novel form of muscular dystrophy. |journal=Nat. Genet. |volume=17 |issue= 3 |pages= 318–23 |year= 1997 |pmid= 9354797 |doi= 10.1038/ng1197-318
*cite journal | author=Leung E, Lim SP, Berg R, "et al." |title=A novel extracellular domain variant of the human integrin alpha 7 subunit generated by alternative intron splicing. |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 1 |pages= 317–25 |year= 1998 |pmid= 9473524 |doi= 10.1006/bbrc.1998.8092
*cite journal | author=Zolkiewska A, Thompson WC, Moss J |title=Interaction of integrin alpha 7 beta 1 in C2C12 myotubes and in solution with laminin. |journal=Exp. Cell Res. |volume=240 |issue= 1 |pages= 86–94 |year= 1998 |pmid= 9570924 |doi= 10.1006/excr.1998.4002
*cite journal | author=Hayashi YK, Chou FL, Engvall E, "et al." |title=Mutations in the integrin alpha7 gene cause congenital myopathy. |journal=Nat. Genet. |volume=19 |issue= 1 |pages= 94–7 |year= 1998 |pmid= 9590299 |doi= 10.1038/ng0598-94
*cite journal | author=Vignier N, Moghadaszadeh B, Gary F, "et al." |title=Structure, genetic localization, and identification of the cardiac and skeletal muscle transcripts of the human integrin alpha7 gene (ITGA7). |journal=Biochem. Biophys. Res. Commun. |volume=260 |issue= 2 |pages= 357–64 |year= 1999 |pmid= 10403775 |doi= 10.1006/bbrc.1999.0916
*cite journal | author=Tachibana I, Hemler ME |title=Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance. |journal=J. Cell Biol. |volume=146 |issue= 4 |pages= 893–904 |year= 1999 |pmid= 10459022 |doi=
*cite journal | author=Schöber S, Mielenz D, Echtermeyer F, "et al." |title=The role of extracellular and cytoplasmic splice domains of alpha7-integrin in cell adhesion and migration on laminins. |journal=Exp. Cell Res. |volume=255 |issue= 2 |pages= 303–13 |year= 2000 |pmid= 10694445 |doi= 10.1006/excr.2000.4806
*cite journal | author=Wixler V, Geerts D, Laplantine E, "et al." |title=The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes. |journal=J. Biol. Chem. |volume=275 |issue= 43 |pages= 33669–78 |year= 2000 |pmid= 10906324 |doi= 10.1074/jbc.M002519200
*cite journal | author=Burkin DJ, Kim JE, Gu M, Kaufman SJ |title=Laminin and alpha7beta1 integrin regulate agrin-induced clustering of acetylcholine receptors. |journal=J. Cell. Sci. |volume=113 ( Pt 16) |issue= |pages= 2877–86 |year= 2000 |pmid= 10910772 |doi=
*cite journal | author=Vizirianakis IS, Yao CC, Chen Y, "et al." |title=Transfection of MCF-7 carcinoma cells with human integrin alpha7 cDNA promotes adhesion to laminin. |journal=Arch. Biochem. Biophys. |volume=385 |issue= 1 |pages= 108–16 |year= 2001 |pmid= 11361006 |doi= 10.1006/abbi.2000.2134

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes