CD11a

CD11a

Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a human gene. PBB_Summary
section_title =
summary_text = ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. [cite web | title = Entrez Gene: ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3683| accessdate = ]

CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1.

Efalizumab acts as an immunosuppressant by binding to CD11a.

ee also

* CD11c
* integrin
* leukocyte adhesion deficiency

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lub M, van Kooyk Y, Figdor CG |title=Ins and outs of LFA-1. |journal=Immunol. Today |volume=16 |issue= 10 |pages= 479–83 |year= 1995 |pmid= 7576051 |doi=
*cite journal | author=Dickeson SK, Santoro SA |title=Ligand recognition by the I domain-containing integrins. |journal=Cell. Mol. Life Sci. |volume=54 |issue= 6 |pages= 556–66 |year= 1998 |pmid= 9676575 |doi=
*cite journal | author=Porter JC, Hogg N |title=Integrins take partners: cross-talk between integrins and other membrane receptors. |journal=Trends Cell Biol. |volume=8 |issue= 10 |pages= 390–6 |year= 1999 |pmid= 9789327 |doi=
*cite journal | author=Giblin PA, Lemieux RM |title=LFA-1 as a key regulator of immune function: approaches toward the development of LFA-1-based therapeutics. |journal=Curr. Pharm. Des. |volume=12 |issue= 22 |pages= 2771–95 |year= 2006 |pmid= 16918410 |doi=
*cite journal | author=Maurer D, Holter W, Majdic O, "et al." |title=CD27 expression by a distinct subpopulation of human B lymphocytes. |journal=Eur. J. Immunol. |volume=20 |issue= 12 |pages= 2679–84 |year= 1991 |pmid= 1702722 |doi=
*cite journal | author=Kalter DC, Gendelman HE, Meltzer MS |title=Inhibition of human immunodeficiency virus infection in monocytes by monoclonal antibodies against leukocyte adhesion molecules. |journal=Immunol. Lett. |volume=30 |issue= 2 |pages= 219–27 |year= 1992 |pmid= 1757107 |doi=
*cite journal | author=Alvarez V, Pulido R, Campanero MR, "et al." |title=Differentially regulated cell surface expression of leukocyte adhesion receptors on neutrophils. |journal=Kidney Int. |volume=40 |issue= 5 |pages= 899–905 |year= 1992 |pmid= 1762294 |doi=
*cite journal | author=Valentin A, Lundin K, Patarroyo M, Asjö B |title=The leukocyte adhesion glycoprotein CD18 participates in HIV-1-induced syncytia formation in monocytoid and T cells. |journal=J. Immunol. |volume=144 |issue= 3 |pages= 934–7 |year= 1990 |pmid= 1967280 |doi=
*cite journal | author=Larson RS, Corbi AL, Berman L, Springer T |title=Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily. |journal=J. Cell Biol. |volume=108 |issue= 2 |pages= 703–12 |year= 1989 |pmid= 2537322 |doi=
*cite journal | author=Hildreth JE, Orentas RJ |title=Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation. |journal=Science |volume=244 |issue= 4908 |pages= 1075–8 |year= 1989 |pmid= 2543075 |doi=
*cite journal | author=Sanders ME, Makgoba MW, Sharrow SO, "et al." |title=Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production. |journal=J. Immunol. |volume=140 |issue= 5 |pages= 1401–7 |year= 1988 |pmid= 2894392 |doi=
*cite journal | author=Corbi AL, Larson RS, Kishimoto TK, "et al." |title=Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion. |journal=J. Exp. Med. |volume=167 |issue= 5 |pages= 1597–607 |year= 1988 |pmid= 3284962 |doi=
*cite journal | author=te Velde AA, Keizer GD, Figdor CG |title=Differential function of LFA-1 family molecules (CD11 and CD18) in adhesion of human monocytes to melanoma and endothelial cells. |journal=Immunology |volume=61 |issue= 3 |pages= 261–7 |year= 1987 |pmid= 3301632 |doi=
*cite journal | author=Qu A, Leahy DJ |title=Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 22 |pages= 10277–81 |year= 1995 |pmid= 7479767 |doi=
*cite journal | author=Turner ML, McIlwaine K, Anthony RS, Parker AC |title=Differential expression of cell adhesion molecules by human hematopoietic progenitor cells from bone marrow and mobilized adult peripheral blood. |journal=Stem Cells |volume=13 |issue= 3 |pages= 311–6 |year= 1995 |pmid= 7542116 |doi=
*cite journal | author=Marzusch K, Ruck P, Geiselhart A, "et al." |title=Distribution of cell adhesion molecules on CD56++, CD3-, CD16- large granular lymphocytes and endothelial cells in first-trimester human decidua. |journal=Hum. Reprod. |volume=8 |issue= 8 |pages= 1203–8 |year= 1993 |pmid= 7691868 |doi=
*cite journal | author=Capobianchi MR, Ameglio F, Cordiali Fei P, "et al." |title=Coordinate induction of interferon alpha and gamma by recombinant HIV-1 glycoprotein 120. |journal=AIDS Res. Hum. Retroviruses |volume=9 |issue= 10 |pages= 957–62 |year= 1994 |pmid= 7904170 |doi=
*cite journal | author=Berman PW, Nakamura GR |title=Adhesion mediated by intercellular adhesion molecule 1 attenuates the potency of antibodies that block HIV-1 gp160-dependent syncytium formation. |journal=AIDS Res. Hum. Retroviruses |volume=10 |issue= 5 |pages= 585–93 |year= 1994 |pmid= 7917519 |doi=
*cite journal | author=Chirmule N, Oyaizu N, Saxinger C, Pahwa S |title=Nef protein of HIV-1 has B-cell stimulatory activity. |journal=AIDS |volume=8 |issue= 6 |pages= 733–4 |year= 1994 |pmid= 8086129 |doi=

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • LFA-1 — (= CD11a/CD18; lymphocyte function related antigen 1) Heterodimeric lymphocyte plasma membrane protein ( aL 180 kD, b 95 kD) that binds ICAM 1, particularly involved in cytotoxic T cell killing. One of the integrin superfamily of adhesion… …   Dictionary of molecular biology

  • Интегрин альфа-L — Структура молекулы ITGAL Обо …   Википедия

  • Odulimomab — ? Monoclonal antibody Type Whole antibody Source Mouse Target CD11a Clinical data Pregnancy cat.  ? Legal status …   Wikipedia

  • CD18 — Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) PDB rendering based on 1l3y …   Wikipedia

  • Efalizumab — drugbox type = mab source = Human target = CD11a CAS number = 214745 43 4 ATC prefix = L04 ATC suffix = AA21 ATC supplemental = PubChem = DrugBank = BTD00074 chemical formula = molecular weight = bioavailability = protein bound = metabolism =… …   Wikipedia

  • Macrophage-1 antigen — (or integrin alphaMbeta2) is a complement receptor ( CR3 ) consisting of CD11b and CD18.[1] It binds to C3b and C4b. Contents 1 Function 2 Synonyms and abbreviations 3 …   Wikipedia

  • Integrin — Integrins are cell surface receptors that interact with the extracellular matrix (ECM) and mediate various intracellular signals. They define cellular shape, mobility, and regulate the cell cycle. These integral membrane proteins are attached to… …   Wikipedia

  • Thalidomide — This article is about the drug. For the musical about a person with thalidomide disability, see Thalidomide!! A Musical. Thalidomide Systematic (IUPAC) name (RS) 2 (2,6 dioxopiperidin 3 yl) 1H isoind …   Wikipedia

  • Ciclosporin — Cyclosporin redirects here. For other types of cyclosporin, see Cyclosporins. Ciclosporin Systematic ( …   Wikipedia

  • Methotrexate — Amethopterin redirects here. Not to be confused with aminopterin. Methotrexate Systematic ( …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”