- CDH8
Cadherin 8, type 2, also known as CDH8, is a human
gene .cite web | title = Entrez Gene: CDH8 cadherin 8, type 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1006| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance.cite web | title = Entrez Gene: CDH8 cadherin 8, type 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1006| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Suzuki S, Sano K, Tanihara H |title=Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. |journal=Cell Regul. |volume=2 |issue= 4 |pages= 261–70 |year= 1991 |pmid= 2059658 |doi=
*cite journal | author=Tanihara H, Sano K, Heimark RL, "et al." |title=Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. |journal=Cell Adhes. Commun. |volume=2 |issue= 1 |pages= 15–26 |year= 1995 |pmid= 7982033 |doi=
*cite journal | author=Kido M, Obata S, Tanihara H, "et al." |title=Molecular properties and chromosomal location of cadherin-8. |journal=Genomics |volume=48 |issue= 2 |pages= 186–94 |year= 1998 |pmid= 9521872 |doi= 10.1006/geno.1997.5152
*cite journal | author=Kremmidiotis G, Baker E, Crawford J, "et al." |title=Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. |journal=Genomics |volume=49 |issue= 3 |pages= 467–71 |year= 1998 |pmid= 9615235 |doi= 10.1006/geno.1998.5281
*cite journal | author=Shimoyama Y, Tsujimoto G, Kitajima M, Natori M |title=Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. |journal=Biochem. J. |volume=349 |issue= Pt 1 |pages= 159–67 |year= 2001 |pmid= 10861224 |doi=
*cite journal | author=Blaschke S, Mueller CA, Markovic-Lipkovski J, "et al." |title=Expression of cadherin-8 in renal cell carcinoma and fetal kidney. |journal=Int. J. Cancer |volume=101 |issue= 4 |pages= 327–34 |year= 2002 |pmid= 12209956 |doi= 10.1002/ijc.10623
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504PBB_Controls
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