- Desmoglein
-
The desmogleins are a family of cadherins consisting of proteins DSG1, DSG2, DSG3, and DSG4. They play a role in the formation of desmosomes that join cells to one another.
Pathology
Desmogleins are targeted in the autoimmune disease pemphigus.[1][2][3]
References
- ^ Waschke J, Bruggeman P, Baumgartner W, Zillikens D, Drenckhahn D (November 2005). "Pemphigus foliaceus IgG causes dissociation of desmoglein 1–containing junctions without blocking desmoglein 1 transinteraction". J. Clin. Invest. 115 (11): 3157–65. doi:10.1172/JCI23475. PMC 1242188. PMID 16211092. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1242188.
- ^ Kljuic A, Bazzi H, Sundberg JP, et al. (April 2003). "Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris". Cell 113 (2): 249–60. doi:10.1016/S0092-8674(03)00273-3. PMID 12705872. http://linkinghub.elsevier.com/retrieve/pii/S0092867403002733.
- ^ Müller R, Heber B, Hashimoto T, et al. (May 2009). "Autoantibodies against desmocollins in European patients with pemphigus". Clin. Exp. Dermatol. 34 (8): 898–903. doi:10.1111/j.1365-2230.2009.03241.x. PMID 19456767.
External links
Calcium-dependent ClassicalUnconventional/ungroupedOther Lymphocyte homing receptor: CD44 · L-selectin · integrin (VLA-4, LFA-1)
Carcinoembryonic antigen · CD22 · CD24 · CD44 · CD146 · CD164see also cell membrane protein disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othrHistology: Epithelial proteins (TH H1.00.01.1) Lateral/cell-cell Cell adhesion molecules: Adherens junction (Cadherin) · Desmosome (Desmoglein)
Ion channels: Gap junction/Connexon (Connexin)
Cytoskeleton: Desmosome (Desmoplakin, Plakoglobin, Tonofibril)
other membrane proteins: Tight junction (Claudin, Occludin, MARVELD2)Basal/cell-matrix Apical B strc: edmb (perx), skel (ctrs), epit, cili, mito, nucl (chro) Categories:- Protein stubs
- Proteins
Wikimedia Foundation. 2010.
