The desmogleins are a family of cadherins consisting of proteins DSG1, DSG2, DSG3, and DSG4. They play a role in the formation of desmosomes that join cells to one another.


Desmogleins are targeted in the autoimmune disease pemphigus.[1][2][3]


  1. ^ Waschke J, Bruggeman P, Baumgartner W, Zillikens D, Drenckhahn D (November 2005). "Pemphigus foliaceus IgG causes dissociation of desmoglein 1–containing junctions without blocking desmoglein 1 transinteraction". J. Clin. Invest. 115 (11): 3157–65. doi:10.1172/JCI23475. PMC 1242188. PMID 16211092. 
  2. ^ Kljuic A, Bazzi H, Sundberg JP, et al. (April 2003). "Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris". Cell 113 (2): 249–60. doi:10.1016/S0092-8674(03)00273-3. PMID 12705872. 
  3. ^ Müller R, Heber B, Hashimoto T, et al. (May 2009). "Autoantibodies against desmocollins in European patients with pemphigus". Clin. Exp. Dermatol. 34 (8): 898–903. doi:10.1111/j.1365-2230.2009.03241.x. PMID 19456767. 

External links

Calcium-dependent Other see also cell membrane protein disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr

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  • desmoglein — des·mog·le·in (dez mogґle in) any of a family of cadherins found in desmosomes; they are the target of autoantibodies in pemphigus foliaceus and pemphigus vulgaris. Cf. desmocollin …   Medical dictionary

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