- CDH12
Cadherin 12, type 2 (N-cadherin 2), also known as CDH12, is a human
gene .cite web | title = Entrez Gene: CDH12 cadherin 12, type 2 (N-cadherin 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1010| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.cite web | title = Entrez Gene: CDH12 cadherin 12, type 2 (N-cadherin 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1010| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Weissenbach J, Gyapay G, Dib C, "et al." |title=A second-generation linkage map of the human genome. |journal=Nature |volume=359 |issue= 6398 |pages= 794–801 |year= 1992 |pmid= 1436057 |doi= 10.1038/359794a0
*cite journal | author=Suzuki S, Sano K, Tanihara H |title=Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. |journal=Cell Regul. |volume=2 |issue= 4 |pages= 261–70 |year= 1991 |pmid= 2059658 |doi=
*cite journal | author=Gyapay G, Morissette J, Vignal A, "et al." |title=The 1993-94 Généthon human genetic linkage map. |journal=Nat. Genet. |volume=7 |issue= 2 Spec No |pages= 246–339 |year= 1994 |pmid= 7545953 |doi= 10.1038/ng0694supp-246
*cite journal | author=Selig S, Bruno S, Scharf JM, "et al." |title=Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 9 |pages= 3702–6 |year= 1995 |pmid= 7731968 |doi=
*cite journal | author=Tanihara H, Sano K, Heimark RL, "et al." |title=Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. |journal=Cell Adhes. Commun. |volume=2 |issue= 1 |pages= 15–26 |year= 1995 |pmid= 7982033 |doi=
*cite journal | author=Selig S, Lidov HG, Bruno SA, "et al." |title=Molecular characterization of Br-cadherin, a developmentally regulated, brain-specific cadherin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 6 |pages= 2398–403 |year= 1997 |pmid= 9122206 |doi=
*cite journal | author=Kremmidiotis G, Baker E, Crawford J, "et al." |title=Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. |journal=Genomics |volume=49 |issue= 3 |pages= 467–71 |year= 1998 |pmid= 9615235 |doi= 10.1006/geno.1998.5281
*cite journal | author=Chalmers IJ, Höfler H, Atkinson MJ |title=Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. |journal=Genomics |volume=57 |issue= 1 |pages= 160–3 |year= 1999 |pmid= 10191097 |doi= 10.1006/geno.1998.5717
*cite journal | author=Shimoyama Y, Tsujimoto G, Kitajima M, Natori M |title=Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. |journal=Biochem. J. |volume=349 |issue= Pt 1 |pages= 159–67 |year= 2001 |pmid= 10861224 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes
Wikimedia Foundation. 2010.
