Desmoglein 1

Desmoglein 1
Desmoglein 1
Symbols DSG1; CDHF4; DG1; DSG; PPKS1; SPPK1
External IDs OMIM125670 MGI94930 HomoloGene1463 GeneCards: DSG1 Gene
RNA expression pattern
PBB GE DSG1 206642 at tn.png
More reference expression data
Species Human Mouse
Entrez 1828 13510
Ensembl ENSG00000134760 ENSMUSG00000069441
UniProt Q02413 Q61495
RefSeq (mRNA) NM_001942.2 NM_010079.2
RefSeq (protein) NP_001933.2 NP_034209.2
Location (UCSC) Chr 18:
28.9 – 28.94 Mb
Chr 18:
20.47 – 20.5 Mb
PubMed search [1] [2]

Desmoglein 1 is a protein that in humans is encoded by the DSG1 gene.[1][2]

Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.[2]



Desmoglein 1 has been shown to interact with PKP3[3] and PKP2.[4]

See also


  1. ^ Arnemann J, Spurr NK, Wheeler GN, Parker AE, Buxton RS (Oct 1991). "Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)". Genomics 10 (3): 640–5. doi:10.1016/0888-7543(91)90446-L. PMID 1889810. 
  2. ^ a b "Entrez Gene: DSG1 desmoglein 1". 
  3. ^ Bonné, Stefan; Gilbert Barbara, Hatzfeld Mechthild, Chen Xinyu, Green Kathleen J, van Roy Frans (Apr. 2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. (United States) 161 (2): 403–16. doi:10.1083/jcb.200303036. ISSN 0021-9525. PMC 2172904. PMID 12707304. 
  4. ^ Chen, Xinyu; Bonne Stefan, Hatzfeld Mechthild, van Roy Frans, Green Kathleen J (Mar. 2002). "Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling". J. Biol. Chem. (United States) 277 (12): 10512–22. doi:10.1074/jbc.M108765200. ISSN 0021-9258. PMID 11790773. 

Further reading

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  • Desmoglein 2 — Identifiers Symbols DSG2; ARVC10; ARVD10; CDHF5; CMD1BB; HDGC; MGC117034; MGC117036; MGC117037 External IDs …   Wikipedia

  • Desmoglein — Das Desmoglein Protein ist ein integrales Membranprotein und gehört zur Gruppe der Calcium bindenden Cadherine. Man findet es in Epithelien wieder, wo es ein Bestandteil der Desmosomen (Macula adhaerens) ist, einem Interzellulkarkontakt.… …   Deutsch Wikipedia

  • Desmoglein — The desmogleins are a family of cadherins consisting of proteins DSG1, DSG2, DSG3, and DSG4. They play a role in the formation of desmosomes that join cells to one another. Pathology Desmogleins are targeted in the autoimmune disease… …   Wikipedia

  • desmoglein — Transmembrane glycoprotein (165 kD) found in desmosomes …   Dictionary of molecular biology

  • desmoglein — des·mog·le·in (dez mogґle in) any of a family of cadherins found in desmosomes; they are the target of autoantibodies in pemphigus foliaceus and pemphigus vulgaris. Cf. desmocollin …   Medical dictionary

  • Dsg — desmoglein …   Medical dictionary

  • Dsg — • desmoglein …   Dictionary of medical acronyms & abbreviations

  • DSG4 — Desmoglein 4 Identifiers Symbols DSG4; CDGF13; CDHF13; LAH External IDs OMIM:&# …   Wikipedia

  • Pemphigus — Classification and external resources ICD 10 L10 ICD …   Wikipedia

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