CDH4

Cadherin 4, type 1, R-cadherin (retinal), also known as CDH4, is a human gene.cite web | title = Entrez Gene: CDH4 cadherin 4, type 1, R-cadherin (retinal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1002| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.cite web | title = Entrez Gene: CDH4 cadherin 4, type 1, R-cadherin (retinal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1002| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tagliarini F |title= [Relations between social defense and criminological trends from the 1930s until today] |journal=Quaderni di criminologia clinica |volume=18 |issue= 3 |pages= 289–352 |year= 1977 |pmid= 798233 |doi=
*cite journal | author=Suzuki S, Sano K, Tanihara H |title=Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. |journal=Cell Regul. |volume=2 |issue= 4 |pages= 261–70 |year= 1991 |pmid= 2059658 |doi=
*cite journal | author=Tanihara H, Sano K, Heimark RL, "et al." |title=Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. |journal=Cell Adhes. Commun. |volume=2 |issue= 1 |pages= 15–26 |year= 1995 |pmid= 7982033 |doi=
*cite journal | author=Chalmers IJ, Höfler H, Atkinson MJ |title=Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. |journal=Genomics |volume=57 |issue= 1 |pages= 160–3 |year= 1999 |pmid= 10191097 |doi= 10.1006/geno.1998.5717
*cite journal | author=Kools P, Vanhalst K, van Roy F |title=Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3. |journal=Cytogenet. Cell Genet. |volume=86 |issue= 1 |pages= 26–7 |year= 1999 |pmid= 10516427 |doi=
*cite journal | author=Shan WS, Tanaka H, Phillips GR, "et al." |title=Functional cis-heterodimers of N- and R-cadherins. |journal=J. Cell Biol. |volume=148 |issue= 3 |pages= 579–90 |year= 2000 |pmid= 10662782 |doi=
*cite journal | author=Lecanda F, Cheng SL, Shin CS, "et al." |title=Differential regulation of cadherins by dexamethasone in human osteoblastic cells. |journal=J. Cell. Biochem. |volume=77 |issue= 3 |pages= 499–506 |year= 2000 |pmid= 10760957 |doi=
*cite journal | author=Kitagawa M, Natori M, Murase S, "et al." |title=Mutation analysis of cadherin-4 reveals amino acid residues of EC1 important for the structure and function. |journal=Biochem. Biophys. Res. Commun. |volume=271 |issue= 2 |pages= 358–63 |year= 2000 |pmid= 10799302 |doi= 10.1006/bbrc.2000.2636
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Johnson E, Theisen CS, Johnson KR, Wheelock MJ |title=R-cadherin influences cell motility via Rho family GTPases. |journal=J. Biol. Chem. |volume=279 |issue= 30 |pages= 31041–9 |year= 2004 |pmid= 15143071 |doi= 10.1074/jbc.M400024200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Miotto E, Sabbioni S, Veronese A, "et al." |title=Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer. |journal=Cancer Res. |volume=64 |issue= 22 |pages= 8156–9 |year= 2005 |pmid= 15548679 |doi= 10.1158/0008-5472.CAN-04-3000
*cite journal | author=Maeda M, Johnson E, Mandal SH, "et al." |title=Expression of inappropriate cadherins by epithelial tumor cells promotes endocytosis and degradation of E-cadherin via competition for p120(ctn). |journal=Oncogene |volume=25 |issue= 33 |pages= 4595–604 |year= 2006 |pmid= 16786001 |doi= 10.1038/sj.onc.1209396

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