CDH17

Cadherin 17, LI cadherin (liver-intestine), also known as CDH17, is a human gene.cite web | title = Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1015| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.cite web | title = Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1015| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gessner R, Tauber R |title=Intestinal cell adhesion molecules. Liver-intestine cadherin. |journal=Ann. N. Y. Acad. Sci. |volume=915 |issue= |pages= 136–43 |year= 2001 |pmid= 11193569 |doi=
*cite journal | author=Gilston A |title=Reducing the hazard of disconnected tubes. |journal=Anaesthesia |volume=32 |issue= 9 |pages= 922 |year= 1978 |pmid= 603017 |doi=
*cite journal | author=Dantzig AH, Hoskins JA, Tabas LB, "et al." |title=Association of intestinal peptide transport with a protein related to the cadherin superfamily. |journal=Science |volume=264 |issue= 5157 |pages= 430–3 |year= 1994 |pmid= 8153632 |doi=
*cite journal | author=Kremmidiotis G, Baker E, Crawford J, "et al." |title=Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. |journal=Genomics |volume=49 |issue= 3 |pages= 467–71 |year= 1998 |pmid= 9615235 |doi= 10.1006/geno.1998.5281
*cite journal | author=Chalmers IJ, Höfler H, Atkinson MJ |title=Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. |journal=Genomics |volume=57 |issue= 1 |pages= 160–3 |year= 1999 |pmid= 10191097 |doi= 10.1006/geno.1998.5717
*cite journal | author=Suzuki Y, Tsunoda T, Sese J, "et al." |title=Identification and characterization of the potential promoter regions of 1031 kinds of human genes. |journal=Genome Res. |volume=11 |issue= 5 |pages= 677–84 |year= 2001 |pmid= 11337467 |doi= 10.1101/gr.164001
*cite journal | author=Grötzinger C, Kneifel J, Patschan D, "et al." |title=LI-cadherin: a marker of gastric metaplasia and neoplasia. |journal=Gut |volume=49 |issue= 1 |pages= 73–81 |year= 2001 |pmid= 11413113 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Takamura M, Sakamoto M, Ino Y, "et al." |title=Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreas. |journal=Cancer Sci. |volume=94 |issue= 5 |pages= 425–30 |year= 2003 |pmid= 12824888 |doi=
*cite journal | author=Wendeler MW, Praus M, Jung R, "et al." |title=Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin. |journal=Exp. Cell Res. |volume=294 |issue= 2 |pages= 345–55 |year= 2004 |pmid= 15023525 |doi= 10.1016/j.yexcr.2003.11.022
*cite journal | author=Ko S, Chu KM, Luk JM, "et al." |title=Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis. |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 2 |pages= 562–8 |year= 2004 |pmid= 15178443 |doi= 10.1016/j.bbrc.2004.04.197
*cite journal | author=Takamura M, Ichida T, Matsuda Y, "et al." |title=Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma. |journal=Cancer Lett. |volume=212 |issue= 2 |pages= 253–9 |year= 2004 |pmid= 15279905 |doi= 10.1016/j.canlet.2004.03.016
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Wang XQ, Luk JM, Leung PP, "et al." |title=Alternative mRNA splicing of liver intestine-cadherin in hepatocellular carcinoma. |journal=Clin. Cancer Res. |volume=11 |issue= 2 Pt 1 |pages= 483–9 |year= 2005 |pmid= 15701831 |doi=
*cite journal | author=Wang XQ, Luk JM, Garcia-Barcelo M, "et al." |title=Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma. |journal=Clin. Cancer Res. |volume=12 |issue= 17 |pages= 5248–52 |year= 2007 |pmid= 16951245 |doi= 10.1158/1078-0432.CCR-06-0558

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