CDH3 (gene)

Cadherin 3, type 1, P-cadherin (placental), also known as CDH3, is a human gene.cite web | title = Entrez Gene: CDH3 cadherin 3, type 1, P-cadherin (placental)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1001| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.cite web | title = Entrez Gene: CDH3 cadherin 3, type 1, P-cadherin (placental)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1001| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kaupmann K, Becker-Follmann J, Scherer G, "et al." |title=The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species. |journal=Genomics |volume=14 |issue= 2 |pages= 488–90 |year= 1992 |pmid= 1427864 |doi=
*cite journal | author=Herrenknecht K, Ozawa M, Eckerskorn C, "et al." |title=The uvomorulin-anchorage protein alpha catenin is a vinculin homologue. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 20 |pages= 9156–60 |year= 1991 |pmid= 1924379 |doi=
*cite journal | author=Shimoyama Y, Hirohashi S, Hirano S, "et al." |title=Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. |journal=Cancer Res. |volume=49 |issue= 8 |pages= 2128–33 |year= 1989 |pmid= 2702654 |doi=
*cite journal | author=Shimoyama Y, Yoshida T, Terada M, "et al." |title=Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues. |journal=J. Cell Biol. |volume=109 |issue= 4 Pt 1 |pages= 1787–94 |year= 1989 |pmid= 2793940 |doi=
*cite journal | author=Palacios J, Benito N, Pizarro A, "et al." |title=Anomalous expression of P-cadherin in breast carcinoma. Correlation with E-cadherin expression and pathological features. |journal=Am. J. Pathol. |volume=146 |issue= 3 |pages= 605–12 |year= 1995 |pmid= 7534041 |doi=
*cite journal | author=van der Linden PJ, de Goeij AF, Dunselman GA, "et al." |title=Expression of cadherins and integrins in human endometrium throughout the menstrual cycle. |journal=Fertil. Steril. |volume=63 |issue= 6 |pages= 1210–6 |year= 1995 |pmid= 7538474 |doi=
*cite journal | author=Tang A, Eller MS, Hara M, "et al." |title=E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro. |journal=J. Cell. Sci. |volume=107 ( Pt 4) |issue= |pages= 983–92 |year= 1994 |pmid= 8056851 |doi=
*cite journal | author=Tassin MT, Beziau A, Gubler MC, Boyer B |title=Spatiotemporal expression of molecules associated with junctional complexes during the in vivo maturation of renal podocytes. |journal=Int. J. Dev. Biol. |volume=38 |issue= 1 |pages= 45–54 |year= 1994 |pmid= 8074995 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Navarro P, Lozano E, Cano A |title=Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin. |journal=J. Cell. Sci. |volume=105 ( Pt 4) |issue= |pages= 923–34 |year= 1993 |pmid= 8227214 |doi=
*cite journal | author=Reynolds AB, Daniel JM, Mo YY, "et al." |title=The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts. |journal=Exp. Cell Res. |volume=225 |issue= 2 |pages= 328–37 |year= 1996 |pmid= 8660921 |doi= 10.1006/excr.1996.0183
*cite journal | author=Soler AP, Harner GD, Knudsen KA, "et al." |title=Expression of P-cadherin identifies prostate-specific-antigen-negative cells in epithelial tissues of male sexual accessory organs and in prostatic carcinomas. Implications for prostate cancer biology. |journal=Am. J. Pathol. |volume=151 |issue= 2 |pages= 471–8 |year= 1997 |pmid= 9250159 |doi=
*cite journal | author=Wakita H, Furukawa F, Baba S, Takigawa M |title=Human squamous-cell-carcinoma cell line (DJM-1) cells synthesize P-cadherin molecules via an elevation of extracellular calcium: calcium regulates P-cadherin-gene expression at the translational level via protein tyrosine phosphorylation. |journal=Int. J. Cancer |volume=73 |issue= 3 |pages= 432–9 |year= 1997 |pmid= 9359492 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Kremmidiotis G, Baker E, Crawford J, "et al." |title=Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. |journal=Genomics |volume=49 |issue= 3 |pages= 467–71 |year= 1998 |pmid= 9615235 |doi= 10.1006/geno.1998.5281
*cite journal | author=Jarrard DF, Paul R, van Bokhoven A, "et al." |title=P-Cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer. |journal=Clin. Cancer Res. |volume=3 |issue= 11 |pages= 2121–8 |year= 1999 |pmid= 9815605 |doi=
*cite journal | author=Schmeiser K, Grand RJ |title=The fate of E- and P-cadherin during the early stages of apoptosis. |journal=Cell Death Differ. |volume=6 |issue= 4 |pages= 377–86 |year= 1999 |pmid= 10381631 |doi= 10.1038/sj.cdd.4400504
*cite journal | author=Rufas O, Fisch B, Ziv S, Shalgi R |title=Expression of cadherin adhesion molecules on human gametes. |journal=Mol. Hum. Reprod. |volume=6 |issue= 2 |pages= 163–9 |year= 2000 |pmid= 10655458 |doi=
*cite journal | author=Klingelhöfer J, Troyanovsky RB, Laur OY, Troyanovsky S |title=Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions. |journal=J. Cell. Sci. |volume=113 ( Pt 16) |issue= |pages= 2829–36 |year= 2000 |pmid= 10910767 |doi=
*cite journal | author=Han AC, Edelson MI, Peralta Soler A, "et al." |title=Cadherin expression in glandular tumors of the cervix. |journal=Cancer |volume=89 |issue= 10 |pages= 2053–8 |year= 2000 |pmid= 11066045 |doi=

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