BCL2A1

BCL2-related protein A1, also known as BCL2A1, is a human gene.cite web | title = Entrez Gene: BCL2A1 BCL2-related protein A1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=597| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the bcl2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.cite web | title = Entrez Gene: BCL2A1 BCL2-related protein A1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=597| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Choi SS, Park IC, Yun JW, "et al." |title=A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow. |journal=Oncogene |volume=11 |issue= 9 |pages= 1693–8 |year= 1995 |pmid= 7478596 |doi=
*cite journal | author=Lin EY, Orlofsky A, Berger MS, Prystowsky MB |title=Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2. |journal=J. Immunol. |volume=151 |issue= 4 |pages= 1979–88 |year= 1993 |pmid= 8345191 |doi=
*cite journal | author=Savitsky K, Sfez S, Tagle DA, "et al." |title=The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. |journal=Hum. Mol. Genet. |volume=4 |issue= 11 |pages= 2025–32 |year= 1996 |pmid= 8589678 |doi=
*cite journal | author=Karsan A, Yee E, Kaushansky K, Harlan JM |title=Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells. |journal=Blood |volume=87 |issue= 8 |pages= 3089–96 |year= 1996 |pmid= 8605321 |doi=
*cite journal | author=Karsan A, Yee E, Harlan JM |title=Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1. |journal=J. Biol. Chem. |volume=271 |issue= 44 |pages= 27201–4 |year= 1996 |pmid= 8910286 |doi=
*cite journal | author=Carrió R, López-Hoyos M, Jimeno J, "et al." |title=A1 demonstrates restricted tissue distribution during embryonic development and functions to protect against cell death. |journal=Am. J. Pathol. |volume=149 |issue= 6 |pages= 2133–42 |year= 1997 |pmid= 8952545 |doi=
*cite journal | author=Kenny JJ, Knobloch TJ, Augustus M, "et al." |title=GRS, a novel member of the Bcl-2 gene family, is highly expressed in multiple cancer cell lines and in normal leukocytes. |journal=Oncogene |volume=14 |issue= 8 |pages= 997–1001 |year= 1997 |pmid= 9050999 |doi= 10.1038/sj.onc.1200898
*cite journal | author=Choi SS, Park SH, Kim UJ, Shin HS |title=Bfl-1, a Bcl-2-related gene, is the human homolog of the murine A1, and maps to chromosome 15q24.3. |journal=Mamm. Genome |volume=8 |issue= 10 |pages= 781–2 |year= 1997 |pmid= 9321477 |doi=
*cite journal | author=Hsu SY, Kaipia A, McGee E, "et al." |title=Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 23 |pages= 12401–6 |year= 1997 |pmid= 9356461 |doi=
*cite journal | author=Takemoto Y, Furuta M, Sato M, "et al." |title=Growth factor receptor-bound protein 2 (Grb2) association with hemopoietic specific protein 1: linkage between Lck and Grb2. |journal=J. Immunol. |volume=161 |issue= 2 |pages= 625–30 |year= 1998 |pmid= 9670936 |doi=
*cite journal | author=Zong WX, Edelstein LC, Chen C, "et al." |title=The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis. |journal=Genes Dev. |volume=13 |issue= 4 |pages= 382–7 |year= 1999 |pmid= 10049353 |doi=
*cite journal | author=Holmgreen SP, Huang DC, Adams JM, Cory S |title=Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members. |journal=Cell Death Differ. |volume=6 |issue= 6 |pages= 525–32 |year= 1999 |pmid= 10381646 |doi= 10.1038/sj.cdd.4400519
*cite journal | author=Lee HH, Dadgostar H, Cheng Q, "et al." |title=NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 16 |pages= 9136–41 |year= 1999 |pmid= 10430908 |doi=
*cite journal | author=Wang CY, Guttridge DC, Mayo MW, Baldwin AS |title=NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. |journal=Mol. Cell. Biol. |volume=19 |issue= 9 |pages= 5923–9 |year= 1999 |pmid= 10454539 |doi=
*cite journal | author=Tomayko MM, Punt JA, Bolcavage JM, "et al." |title=Expression of the Bcl-2 family member A1 is developmentally regulated in T cells. |journal=Int. Immunol. |volume=11 |issue= 11 |pages= 1753–61 |year= 1999 |pmid= 10545479 |doi=
*cite journal | author=Zhang H, Cowan-Jacob SW, Simonen M, "et al." |title=Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells. |journal=J. Biol. Chem. |volume=275 |issue= 15 |pages= 11092–9 |year= 2000 |pmid= 10753914 |doi=
*cite journal | author=Duriez PJ, Wong F, Dorovini-Zis K, "et al." |title=A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18099–107 |year= 2000 |pmid= 10849436 |doi= 10.1074/jbc.M908925199
*cite journal | author=Harrington JJ, Sherf B, Rundlett S, "et al." |title=Creation of genome-wide protein expression libraries using random activation of gene expression. |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440–5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107
*cite journal | author=Bae J, Hsu SY, Leo CP, "et al." |title=Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis. |journal=Apoptosis |volume=6 |issue= 5 |pages= 319–30 |year= 2001 |pmid= 11483855 |doi=
*cite journal | author=Akari H, Bour S, Kao S, "et al." |title=The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappaB-dependent expression of antiapoptotic factors. |journal=J. Exp. Med. |volume=194 |issue= 9 |pages= 1299–311 |year= 2001 |pmid= 11696595 |doi=

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