AXL receptor tyrosine kinase

AXL receptor tyrosine kinase, also known as AXL, is a human gene.cite web | title = Entrez Gene: AXL AXL receptor tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=558| accessdate = ]

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summary_text = The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduce signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Axl is a chronic myelogenous leukemia-associated oncogene and also associated with colon cancer and melanoma. It is in close vicinity to the bcl3 oncogene which is at 19q13.1-q13.2. The Axl gene is evolutionarily conserved between vertebrate species. This gene has two different alternatively spliced transcript variants.cite web | title = Entrez Gene: AXL AXL receptor tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=558| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Neubauer A, Burchert A, Maiwald C, "et al." |title=Recent progress on the role of Axl, a receptor tyrosine kinase, in malignant transformation of myeloid leukemias. |journal=Leuk. Lymphoma |volume=25 |issue= 1-2 |pages= 91–6 |year= 1997 |pmid= 9130617 |doi=
*cite journal | author=O'Bryan JP, Frye RA, Cogswell PC, "et al." |title=axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. |journal=Mol. Cell. Biol. |volume=11 |issue= 10 |pages= 5016–31 |year= 1991 |pmid= 1656220 |doi=
*cite journal | author=Bergsagel PL, Victor-Kobrin C, Timblin CR, "et al." |title=A murine cDNA encodes a pan-epithelial glycoprotein that is also expressed on plasma cells. |journal=J. Immunol. |volume=148 |issue= 2 |pages= 590–6 |year= 1992 |pmid= 1729376 |doi=
*cite journal | author=Janssen JW, Schulz AS, Steenvoorden AC, "et al." |title=A novel putative tyrosine kinase receptor with oncogenic potential. |journal=Oncogene |volume=6 |issue= 11 |pages= 2113–20 |year= 1991 |pmid= 1834974 |doi=
*cite journal | author=Partanen J, Mäkelä TP, Alitalo R, "et al." |title=Putative tyrosine kinases expressed in K-562 human leukemia cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 22 |pages= 8913–7 |year= 1991 |pmid= 2247464 |doi=
*cite journal | author=Neubauer A, Fiebeler A, Graham DK, "et al." |title=Expression of axl, a transforming receptor tyrosine kinase, in normal and malignant hematopoiesis. |journal=Blood |volume=84 |issue= 6 |pages= 1931–41 |year= 1994 |pmid= 7521695 |doi=
*cite journal | author=O'Bryan JP, Fridell YW, Koski R, "et al." |title=The transforming receptor tyrosine kinase, Axl, is post-translationally regulated by proteolytic cleavage. |journal=J. Biol. Chem. |volume=270 |issue= 2 |pages= 551–7 |year= 1995 |pmid= 7822279 |doi=
*cite journal | author=Lee ST, Strunk KM, Spritz RA |title=A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. |journal=Oncogene |volume=8 |issue= 12 |pages= 3403–10 |year= 1993 |pmid= 8247543 |doi=
*cite journal | author=Schulz AS, Schleithoff L, Faust M, "et al." |title=The genomic structure of the human UFO receptor. |journal=Oncogene |volume=8 |issue= 2 |pages= 509–13 |year= 1993 |pmid= 8381225 |doi=
*cite journal | author=O'Bryan JP, Songyang Z, Cantley L, "et al." |title=A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 7 |pages= 2729–34 |year= 1996 |pmid= 8610109 |doi=
*cite journal | author=Mark MR, Chen J, Hammonds RG, "et al." |title=Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl. |journal=J. Biol. Chem. |volume=271 |issue= 16 |pages= 9785–9 |year= 1996 |pmid= 8621659 |doi=
*cite journal | author=Braunger J, Schleithoff L, Schulz AS, "et al." |title=Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site. |journal=Oncogene |volume=14 |issue= 22 |pages= 2619–31 |year= 1997 |pmid= 9178760 |doi= 10.1038/sj.onc.1201123
*cite journal | author=Tanaka K, Nagayama Y, Nakano T, "et al." |title=Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid. |journal=Endocrinology |volume=139 |issue= 3 |pages= 852–8 |year= 1998 |pmid= 9492013 |doi=
*cite journal | author=Yanagita M, Arai H, Ishii K, "et al." |title=Gas6 regulates mesangial cell proliferation through Axl in experimental glomerulonephritis. |journal=Am. J. Pathol. |volume=158 |issue= 4 |pages= 1423–32 |year= 2001 |pmid= 11290560 |doi=
*cite journal | author=Sun WS, Misao R, Iwagaki S, "et al." |title=Coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases, Axl and Sky, in human uterine endometrium and ovarian endometriosis. |journal=Mol. Hum. Reprod. |volume=8 |issue= 6 |pages= 552–8 |year= 2003 |pmid= 12029073 |doi=
*cite journal | author=D'Arcangelo D, Gaetano C, Capogrossi MC |title=Acidification prevents endothelial cell apoptosis by Axl activation. |journal=Circ. Res. |volume=91 |issue= 7 |pages= e4–12 |year= 2002 |pmid= 12364394 |doi=
*cite journal | author=Hafizi S, Alindri F, Karlsson R, Dahlbäck B |title=Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 5 |pages= 793–800 |year= 2003 |pmid= 12470648 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ito M, Nakashima M, Nakayama T, "et al." |title=Expression of receptor-type tyrosine kinase, Axl, and its ligand, Gas6, in pediatric thyroid carcinomas around chernobyl. |journal=Thyroid |volume=12 |issue= 11 |pages= 971–5 |year= 2003 |pmid= 12490074 |doi= 10.1089/105072502320908303

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