Properdin

Properdin

protein
Name = complement factor properdin
caption =


width =
HGNCid = 8864
Symbol = CFP
AltSymbols = PFC
EntrezGene = 5199
OMIM = 300383
RefSeq = NM_002621
UniProt = P27918
PDB =
ECnumber =
Chromosome = X
Arm = p
Band = 11.4
LocusSupplementaryData =

Properdin or factor P is a globulin protein found in the blood serum of higher animals. In the complement system, an innate-immunity series of proenzymes dissolved in the circulation, it is also called "Factor P".

Function

It is known that it participates in some specific immune responses. It plays a part in tissue inflammation as well as the engulfing of pathogens by phagocytes. In addition it is known to help to neutralize some viruses.

As a component of the alternative pathway for complement activation (otherwise known as the "properdin pathway"), it complexes with another protein, C3b, to stabilize the alternative C3 convertase (C3bBb) that then cleaves more C3.

The alternative pathway is not dependent on antibodies. This branch of the complement system is activated by IgA immune complexes and bacterial endotoxins, polysaccharides, and cell walls, and results in producing anaphylatoxins, opsonins, chemotactic factors, and the membrane attack complex, all of which help fight pathogens.

History

Properdin was discovered in 1954 by Dr. Louis Pillemer of the Institute of Pathology (now the Department of Pathology at Case Western Reserve University).

External links

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Look at other dictionaries:

  • Properdin —   [Kurzwort] das, s, ein aus vier Untereinheiten bestehendes Serumprotein, das mit Insulin u. a. unlöslichen Polysacchariden Komplexe bildet, die das Komplement, ein Funktionssystem des Blutserums, aktivieren; Properdin ist somit an der… …   Universal-Lexikon

  • properdin — properdin. См. пропердин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • properdin — ☆ properdin [prō pʉrd′ n ] n. 〚/span> PRO(TEIN) + L perdere, to destroy + IN1〛 a protein present in blood serum and active in the destruction of bacteria and the neutralization of viruses * * * pro·per·din (prō pûrʹdn) n. A protein in …   Universalium

  • properdin — ☆ properdin [prō pʉrd′ n ] n. [< PRO(TEIN) + L perdere, to destroy + IN1] a protein present in blood serum and active in the destruction of bacteria and the neutralization of viruses …   English World dictionary

  • properdin — A globulin in normal serum involved in resistance to infection that participates, in conjunction with other factors, in an alternative pathway to the activation of the terminal components of complement; a deficiency of p. results in the lack of… …   Medical dictionary

  • properdin — n. a group of substances in blood plasma that, in combination with complement and magnesium ions, is capable of destroying certain bacteria and viruses. The properdin complex occurs naturally, rather than as the result of previous exposure to… …   The new mediacal dictionary

  • Properdin deficiency — Infobox Disease Name = PAGENAME Caption = DiseasesDB = ICD10 = ICD9 = ICDO = OMIM = 312060 MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID =Properdin deficiency is a rare X linked disease in which properdin, an important complement factor,… …   Wikipedia

  • properdin — noun Etymology: probably from 1pro + Latin perdere to destroy + English 1 in more at perdition Date: 1954 a blood serum protein that participates in the activation of complement in a pathway which does not involve the presence of antibodies …   New Collegiate Dictionary

  • properdin — (= Factor P) Component of the alternative pathway for complement activation: complexes with C3b and stabilizes the alternative pathway C3 convertase (C3bBbP) that cleaves C3 …   Dictionary of molecular biology

  • properdin — noun A protein in human serum that complements part of the immune system …   Wiktionary

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